Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis

• Published in: Journal of gastroenterology and hepatology Vol. 28; no. 4; pp. 723 - 730
• Main Authors: Shirai, Yusaku, Yoshiji, Hitoshi, Noguchi, Ryuichi, Kaji, Kosuke, Aihara, Yosuke, Douhara, Akitoshi, Moriya, Kei, Namisaki, Tadashi, Kawaratani, Hideto, Fukui, Hiroshi
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.04.2013
• Subjects: Angiotensin II - metabolism; Angiotensin II Type 1 Receptor Blockers - pharmacology; angiotensin-II; Animals; Cell Communication - drug effects; Disease Models, Animal; Disease Progression; DNA Primers - chemistry; Dose-Response Relationship, Drug; Fatty Liver - metabolism; Fatty Liver - prevention & control; Gene Expression - drug effects; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; lipopolysaccharide; Liver Cirrhosis - metabolism; Liver Cirrhosis - prevention & control; liver fibrosis; Losartan - pharmacology; Male; NF-kappa B - metabolism; Non-alcoholic Fatty Liver Disease; non-alcoholic steatohepatitis; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; Signal Transduction - physiology; Time Factors; Toll-Like Receptor 4 - metabolism; toll-like receptor-4; Transforming Growth Factor beta - metabolism

Background and Aim The innate immune system, including toll‐like receptor‐4 (TLR4) signaling cascade and angiotensin‐II (AT‐II) play important roles in the progression of liver fibrosis development; the cross talk between TLR4 and AT‐II has not been elucidated yet. The aim of the current study was t...