A Tumor Vascular‐Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia

• Published in: Advanced science Vol. 5; no. 8; pp. 1800034 - n/a
• Main Authors: Luan, Xin, Guan, Ying‐Yun, Liu, Hai‐Jun, Lu, Qin, Zhao, Mei, Sun, Duxin, Lovell, Jonathan F., Sun, Peng, Chen, Hong‐Zhuan, Fang, Chao
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2018; John Wiley and Sons Inc
• Subjects: Cancer therapies; Chemotherapy; Enzymes; Graphene; graphene oxide; Hypoxia; hypoxia‐activated prodrug; Kinases; Ligands; Nanoparticles; Peptides; photodynamic therapy; Polyethylene glycol; Prostate cancer; Statistical analysis; trimodal therapy; tumor hypoxia; Tumors; Canada; United States > US; trimodal therapy; tumor hypoxia; graphene oxide; hypoxia‐activated prodrug; photodynamic therapy

Vascular‐targeted photodynamic therapy (VTP) is a recently approved strategy for treating solid tumors. However, the exacerbated hypoxic stress makes tumor eradication challenging with such a single modality approach. Here, a new graphene oxide (GO)‐based nanosystem for rationally designed, interloc...