p38 MAP kinase regulates TNFα-, IL-1α- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells

• Published in: Clinical and experimental allergy Vol. 30; no. 1; pp. 48 - 55
• Main Authors: HASHIMOTO, S, MATSUMOTO, K, GON, Y, MARUOKA, S, KUJIME, K, HAYASHI, S, TAKESHITA, I, HORIE, T
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.01.2000; Blackwell
• Subjects: Allergic diseases; Animals; Biological and medical sciences; Bronchi - cytology; Bronchi - drug effects; Bronchi - enzymology; Bronchi - metabolism; bronchial epithelial cells; Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinases - metabolism; Calcium-Calmodulin-Dependent Protein Kinases - physiology; Cell Line, Transformed; Chemokine CCL5 - antagonists & inhibitors; Chemokine CCL5 - biosynthesis; Enzyme Inhibitors - pharmacology; Epithelial Cells - drug effects; Epithelial Cells - enzymology; Epithelial Cells - metabolism; GM-CSF; Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Humans; Imidazoles - pharmacology; Immunopathology; interleukin 1^a; Interleukin-1 - antagonists & inhibitors; Interleukin-1 - physiology; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - immunology; Medical sciences; Mitogen-Activated Protein Kinases; p38 MAP kinase; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor - antagonists & inhibitors; Platelet Activating Factor - physiology; platelet-activating factor; Pyridines - pharmacology; Rabbits; RANTES; Respiratory and ent allergic diseases; tumor necrosis factor-^a; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - physiology; Human; Immunopathology; Allergy; Pathophysiology; Respiratory disease; Enzyme; RANTES; Transferases; Cytokine; Interleukin 1α; Inflammation; Platelet activating factor; Chemokine; Respiratory tract; Signal transduction; Polypeptide; Kinase; Epithelial cell; Tumor necrosis factor α; Granulocyte macrophage colony stimulating factor

Background RANTES and granulocyte macrophage‐colony stimulating factor (GM‐CSF) play an important role in the production of allergic inflammation of the airway through their chemotactic activity for eosinophils. Recent studies have indicated that p38 mitogen‐activated protein (MAP) kinase regulates...