Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice

• Published in: Pain (Amsterdam) Vol. 156; no. 6; pp. 1153 - 1160
• Main Authors: Negus, S. Stevens, Neddenriep, Bradley, Altarifi, Ahmad A., Carroll, F. Ivy, Leitl, Michael D., Miller, Laurence L.
• Format: Journal Article
• Language: English
• Published: United States International Association for the Study of Pain 01.06.2015
• Subjects: Analgesics, Opioid - therapeutic use; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Benzeneacetamides - therapeutic use; Depression - drug therapy; Depression - etiology; Dose-Response Relationship, Drug; Freund's Adjuvant - toxicity; Ketoprofen - therapeutic use; Male; Mice; Mice, Inbred ICR; Morphine - therapeutic use; Nesting Behavior - drug effects; Nesting Behavior - physiology; Pain - chemically induced; Pain - complications; Pain - drug therapy; Piperidines - pharmacology; Pyrrolidines - therapeutic use; Receptors, Opioid, kappa - agonists; Receptors, Opioid, kappa - antagonists & inhibitors; Receptors, Opioid, kappa - metabolism; Tetrahydroisoquinolines - pharmacology

Pain-related functional impairment and behavioral depression are diagnostic indicators of pain and targets for its treatment. Nesting is an innate behavior in mice that may be sensitive to pain manipulations and responsive to analgesics. The goal of this study was to develop and validate a procedure...