Neutrophil as a Carrier for Cancer Nanotherapeutics: A Comparative Study of Liposome, PLGA, and Magnetic Nanoparticles Delivery to Tumors

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 11; p. 1564
• Main Authors: Garanina, Anastasiia S., Vishnevskiy, Daniil A., Chernysheva, Anastasia A., Valikhov, Marat P., Malinovskaya, Julia A., Lazareva, Polina A., Semkina, Alevtina S., Abakumov, Maxim A., Naumenko, Victor A.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Ablation; Cancer; Cancer therapies; Care and treatment; cell-based delivery system; Chemical properties; Chemokines; Comparative analysis; Drug delivery systems; Drugs; Efficiency; Evaluation; Health aspects; Inflammation; intravital microscopy; Investigations; Leukocytes; Liposomes; Magnetic properties; Magnetite; Materials; Microscopy; Nanoparticles; Neutrophils; Oncology, Experimental; Photographic industry; Toxicity; tumor; Tumors; Vehicles; Russia; Japan; Germany

Insufficient drug accumulation in tumors is still a major concern for using cancer nanotherapeutics. Here, the neutrophil-based delivery of three nanoparticle types—liposomes, PLGA, and magnetite nanoparticles—was assessed both in vitro and in vivo. Confocal microscopy and a flow cytometry analysis...