ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

• Published in: The Journal of biological chemistry Vol. 284; no. 17; pp. 11738 - 11747
• Main Authors: Tousseyn, Thomas, Thathiah, Amantha, Jorissen, Ellen, Raemaekers, Tim, Konietzko, Uwe, Reiss, Karina, Maes, Elke, Snellinx, An, Serneels, Lutgarde, Nyabi, Omar, Annaert, Wim, Saftig, Paul, Hartmann, Dieter, De Strooper, Bart
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.04.2009; American Society for Biochemistry and Molecular Biology
• Subjects: ADAM Proteins - metabolism; ADAM Proteins - physiology; ADAM10 Protein; Amyloid Precursor Protein Secretases - metabolism; Amyloid Precursor Protein Secretases - physiology; Animals; Cell Nucleus - metabolism; Enzyme Catalysis and Regulation; Gene Expression Regulation, Enzymologic; Membrane Proteins - metabolism; Membrane Proteins - physiology; Mice; Microscopy, Fluorescence; Presenilins - metabolism; Protein Structure, Tertiary; Receptors, Notch - metabolism; Signal Transduction; Subcellular Fractions - metabolism; Tissue Distribution

ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject...