Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents

• Published in: Biochimica et biophysica acta Vol. 1860; no. 7; pp. 1417 - 1430
• Main Authors: Jia, Hui, Yang, Qian, Wang, Tao, Cao, Yu, Jiang, Qi-yu, Ma, Hong-da, Sun, Hui-wei, Hou, Ming-xiao, Yang, Yong-ping, Feng, Fan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2016
• Subjects: agar; Animals; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; breast neoplasms; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Survival - drug effects; cell viability; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; drug therapy; etoposide; Etoposide - pharmacology; flow cytometry; Gene Expression Regulation, Neoplastic; HCC; Hep G2 Cells; hepatoma; Humans; Inhibitory Concentration 50; Liver Neoplasms - drug therapy; Liver Neoplasms - enzymology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; MDR; MDR-related proteins; mice; Mice, SCID; MicroRNAs - genetics; MicroRNAs - metabolism; MiR-34a; multiple drug resistance; neoplasm cells; Niacinamide - analogs & derivatives; Niacinamide - pharmacology; Notch-1 pathway; P-glycoproteins; paclitaxel; Paclitaxel - pharmacology; Phenylurea Compounds - pharmacology; pro-apoptotic proteins; Protein Kinase Inhibitors - pharmacology; quantitative polymerase chain reaction; Quercetin - analogs & derivatives; Quercetin - pharmacology; Receptor, Notch1 - antagonists & inhibitors; Receptor, Notch1 - metabolism; Rhamnetin; signal transduction; Signal Transduction - drug effects; stress response; Transfection; Western blotting; Xenograft Model Antitumor Assays; Rhamnetin; MDR-related proteins; HCC; MDR; MiR-34a; Notch-1 pathway

The rapid development of multi-drug resistance (MDR) process has hindered the effectiveness of advanced hepatocellular carcinoma (HCC) treatments. Notch-1 pathway, which mediates the stress-response, promotes cell survival, EMT (epithelial–mesenchymal transition) process and induces anti-apoptosis i...