Mechanisms of axon regeneration: The significance of proteoglycans

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 10; pp. 2435 - 2441
• Main Authors: Sakamoto, Kazuma, Kadomatsu, Kenji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: Animals; Axon regeneration; axons; Brain - metabolism; Brain - pathology; Brain Chemistry; Carbohydrate Sequence; central nervous system; Ciliary Neurotrophic Factor - genetics; Ciliary Neurotrophic Factor - metabolism; Diffuse Axonal Injury - genetics; Diffuse Axonal Injury - metabolism; Diffuse Axonal Injury - pathology; Diffuse Axonal Injury - rehabilitation; Gene Expression Regulation; Glycosaminoglycans; Humans; Leukemia Inhibitory Factor - genetics; Leukemia Inhibitory Factor - metabolism; ligands; Nerve Regeneration - physiology; Neural plasticity; Neuronal Plasticity - physiology; Neurons - cytology; Neurons - physiology; neuroplasticity; Proteoglycans; Proteoglycans - chemistry; Proteoglycans - genetics; Proteoglycans - metabolism; receptors; Signal Transduction; STAT Transcription Factors - genetics; STAT Transcription Factors - metabolism; therapeutics; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Neural plasticity; Proteoglycans; Glycosaminoglycans; Axon regeneration

Therapeutics specific to neural injury have long been anticipated but remain unavailable. Axons in the central nervous system do not readily regenerate after injury, leading to dysfunction of the nervous system. This failure of regeneration is due to both the low intrinsic capacity of axons for rege...