Serotonin control of sleep-wake behavior

• Published in: Sleep medicine reviews Vol. 15; no. 4; pp. 269 - 281
• Main Author: Monti, Jaime M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2011
• Subjects: 5-HT receptors; Animals; Basal forebrain; Brain - physiology; Brain stem; Dorsal raphe nucleus; Humans; Laterodorsal and pedunculopontine tegmental nuclei; Mice; Neurology; Raphe Nuclei - physiology; Rapid eye movement sleep; Rats; Receptors, Serotonin - physiology; Serotonin; Serotonin - physiology; Sleep; Sleep - physiology; Sleep Medicine; Sleep Wake Disorders - physiopathology; Sleep, REM - physiology; Slow wave sleep; Wakefulness; Wakefulness - physiology; Sleep; Serotonin; Brain stem; Wakefulness; Dorsal raphe nucleus; Basal forebrain; Rapid eye movement sleep; Slow wave sleep; 5-HT receptors; Laterodorsal and pedunculopontine tegmental nuclei

Based on electrophysiological, neurochemical, genetic and neuropharmacological approaches, it is currently accepted that serotonin (5-HT) functions predominantly to promote wakefulness (W) and to inhibit REM (rapid eye movement) sleep (REMS). Yet, under certain circumstances the neurotransmitter con...