Compound sophorae decoction enhances intestinal barrier function of dextran sodium sulfate induced colitis via regulating notch signaling pathway in mice

• Published in: Biomedicine & pharmacotherapy Vol. 133; p. 110937
• Main Authors: Wu, Hui, Chen, Qian-Yun, Wang, Wen-Zhu, Chu, Si, Liu, Xing-Xing, Liu, Yu-Jin, Tan, Chen, Zhu, Feng, Deng, Shuang-Jiao, Dong, Ya-Lan, Yu, Ting, Gao, Fei, He, Hong-Xia, Leng, Xue-Yuan, Fan, Heng
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2021
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Apoptosis - drug effects; Barrier function; Cell Proliferation - drug effects; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colitis - pathology; Colon - drug effects; Colon - metabolism; Colon - pathology; Compound sophorae decoction; Cytokines - metabolism; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Intestinal epithelial cells; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Mucin-2 - metabolism; Mucus; Notch; Occludin - metabolism; Permeability; Receptors, Notch - metabolism; Regeneration - drug effects; Signal Transduction; Tight Junctions - drug effects; Tight Junctions - metabolism; Tight Junctions - pathology; Ulcerative colitis; Zonula Occludens-1 Protein - metabolism; Mucus; Barrier function; Compound sophorae decoction; Intestinal epithelial cells; Notch; Ulcerative colitis

•Compound sophorae decoction can alleviate the clinical manifestations and pathological damage of UC.•Compound sophorae decoction abates intestinal inflammation and restores colonic barrier function.•Compound sophorae decoction can regulate Notch signaling pathway in DSS-induced colitis mice. Compou...