Compound sophorae decoction enhances intestinal barrier function of dextran sodium sulfate induced colitis via regulating notch signaling pathway in mice - Wu, Hui; Chen, Qian-Yun; Wang, Wen-Zhu; Chu, Si; Liu, Xing-Xing; Liu, Yu-Jin; Tan, Chen; Zhu, Feng; Deng, Shuang-Jiao; Dong, Ya-Lan; Yu, Ting; Gao, Fei; et al. (Biomedicine & pharmacotherapy, 2021)
Keywords: Animals; Anti-Inflammatory Agents - pharmacology; Apoptosis - drug effects; Barrier function; Cell Proliferation - drug effects; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colitis - pathology; Colon - drug effects; Colon - metabolism; Colon - pathology; Compound sophorae decoction; Cytokines - metabolism; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Intestinal epithelial cells; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Mucin-2 - metabolism; Mucus; Notch; Occludin - metabolism; Permeability; Receptors, Notch - metabolism; Regeneration - drug effects; Signal Transduction; Tight Junctions - drug effects; Tight Junctions - metabolism; Tight Junctions - pathology; Ulcerative colitis; Zonula Occludens-1 Protein - metabolism; Mucus; Barrier function; Compound sophorae decoction; Intestinal epithelial cells; Notch; Ulcerative colitis