Berberine prevents damage to the intestinal mucosal barrier during early phase of sepsis in rat through mechanisms independent of the NOD-like receptors signaling pathway

• Published in: European journal of pharmacology Vol. 730; pp. 1 - 7
• Main Authors: Li, Guo-xun, Wang, Xi-mo, Jiang, Tao, Gong, Jian-feng, Niu, Ling-ying, Li, Ning
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.05.2014
• Subjects: Animals; Berberine; Berberine - pharmacology; Carrier Proteins; Cecal ligation and puncture (CLP); Cell Death - drug effects; Claudin-4 - metabolism; Gene Expression Regulation - drug effects; Interleukin-6 - blood; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestinal mucosal barrier; Intra-abdominal infections; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Nod2 Signaling Adaptor Protein - genetics; Nod2 Signaling Adaptor Protein - metabolism; Permeability - drug effects; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Sepsis - metabolism; Sepsis - pathology; Signal Transduction - drug effects; Tight junction proteins; Tumor Necrosis Factor-alpha - blood; Berberine; Intestinal mucosal barrier; Cecal ligation and puncture (CLP); Intra-abdominal infections; Tight junction proteins

NOD-like receptors play a crucial role in host defense against intestinal infection. We explored the regulatory effects of berberine on NLRs during the intestinal mucosal damaging process in rats. Male Sprague-Dawlay (SD) rats were treated with berberine for 5d before undergoing cecal ligation and p...