2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity - Sulkowski, Parker L; Corso, Christopher D; Robinson, Nathaniel D; Scanlon, Susan E; Purshouse, Karin R; Bai, Hanwen; Liu, Yanfeng; Sundaram, Ranjini K; Hegan, Denise C; Fons, Nathan R; Breuer, Gregory A; Song, Yuanbin; et al. (Science translational medicine, 2017)
Keywords: Animals; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; Female; Glioma - drug therapy; Glioma - genetics; Glutarates - pharmacology; Homologous Recombination; Humans; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - pharmacology; Mice, Nude; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Xenograft Model Antitumor Assays