Di-Tyrosine Crosslinking and NOX4 Expression as Oxidative Pathological Markers in the Lungs of Patients with Idiopathic Pulmonary Fibrosis

• Published in: Antioxidants Vol. 10; no. 11; p. 1833
• Main Authors: Blaskovic, Sanja, Donati, Yves, Ruchonnet-Metrailler, Isabelle, Seredenina, Tamara, Krause, Karl-Heinz, Pache, Jean-Claude, Adler, Dan, Barazzone-Argiroffo, Constance, Jaquet, Vincent
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18.11.2021; MDPI
• Subjects: Alzheimer's disease; di-tyrosine; Endothelium; Epithelial cells; Epithelium; Fibroblasts; Fibrosis; Gene expression; Growth factors; Heme; human lung tissue; Hydrogen peroxide; idiopathic pulmonary fibrosis; immunohistochemistry; Localization; Lung diseases; Lungs; Medical research; Monoclonal antibodies; NAD(P)H oxidase; NADPH oxidase; NOX4; NOX4 protein; Oxidants; Pathogenesis; Pathology; Patients; Peroxidase; Physiology; Post-translation; Pulmonary fibrosis; Reagents; Smooth muscle; Transforming growth factor-b1; Tyrosine; Scotland; United Kingdom > UK; United States > US; Switzerland; Germany

Idiopathic pulmonary fibrosis (IPF) is a noninflammatory progressive lung disease. Oxidative damage is a hallmark of IPF, but the sources and consequences of oxidant generation in the lungs are unclear. In this study, we addressed the link between the H2O2-generating enzyme NADPH oxidase 4 (NOX4) an...