Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 136; no. 1; p. 309
• Main Authors: Bonal, Claire, Thorel, Fabrizio, Ait-Lounis, Aouatef, Reith, Walter, Trumpp, Andreas, Herrera, Pedro L
• Format: Journal Article
• Language: English
• Published: United States 01.01.2009
• Subjects: Adipocytes - cytology; Animals; Cell Differentiation; Cell Proliferation; Epithelium - pathology; Homeodomain Proteins - analysis; Humans; Mesoderm - pathology; Mice; Mice, Inbred C57BL; Pancreas, Exocrine - pathology; Proto-Oncogene Proteins c-myc - analysis; Proto-Oncogene Proteins c-myc - physiology; Trans-Activators - analysis

The pancreatic mass is determined by the coordinated expansion and differentiation of progenitor cells and is maintained via tight control of cell replacement rates. The basic helix-loop-helix transcription factor c-Myc is one of the main regulators of these processes in many organs. We studied the...