Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1 - Zhang, Jun; Wang, Quan-zhen; Zhao, Shao-hua; Ji, Xiang; Qiu, Jie; Wang, Jian; Zhou, Yi; Cai, Qian; Zhang, Jie; Gao, Hai-qing (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Acetylation; Animals; antioxidants; aspartate transaminase; Astaxanthin; Cardiac function; cardiac output; fibroblasts; Fibrosis; Heart Diseases - drug therapy; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium - pathology; Phosphorylation; Pressure; R-SMADs; SIRT1; Sirtuin 1 - antagonists & inhibitors; Sirtuin 1 - physiology; Smad2 Protein - physiology; Smad3 Protein - physiology; small interfering RNA; transcription (genetics); transforming growth factor beta 1; Xanthophylls - therapeutic use; EF; AST; TβR II; BNP; R-SMADs; H&E; Astaxanthin; IP; HCFs; EX-527; FS; SIRT1; HW; TβR I; BW; Cardiac function; ROS; TAC; Fibrosis; IB; TGF-β1; IF; TEM