Impact of autoantibody glycosylation in autoimmune diseases

• Published in: Autoimmunity reviews Vol. 13; no. 7; pp. 742 - 750
• Main Authors: Goulabchand, Radjiv, Vincent, Thierry, Batteux, Frédéric, Eliaou, Jean-françois, Guilpain, Philippe
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2014
• Subjects: Allergy and Immunology; Animals; Autoantibodies - immunology; Autoimmune Diseases - immunology; Autoimmune Diseases - therapy; Biomarkers; Glycosylation; Humans; Immunoglobulins - immunology; Immunoglobulins - metabolism; Organ Specificity; Immunoglobulins; Glycosylation; Autoantibodies; Autoimmune diseases; Sialylation

Abstract Objective: Recent outcomes enhanced the critical role of glycosylation pattern of autoantibodies in the pathophysiology of antibody-mediated autoimmune diseases. In this review, we discuss the critical role of immunoglobulin (Ig) glycosylation on skewing immune response towards a pro- or an...