Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium

• Published in: European heart journal Vol. 26; no. 19; pp. 2039 - 2045
• Main Authors: Abbate, Antonio, Bussani, Rossana, Biondi-Zoccai, Giuseppe G.L., Santini, Daniele, Petrolini, Alessandro, Giorgio, Fabio De, Vasaturo, Fortunata, Scarpa, Susanna, Severino, Anna, Liuzzo, Giovanna, Leone, Antonio Maria, Baldi, Feliciano, Sinagra, Gianfranco, Silvestri, Furio, Vetrovec, George W., Crea, Filippo, Biasucci, Luigi M., Baldi, Alfonso
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2005; Oxford Publishing Limited (England)
• Subjects: Actins - metabolism; Aged; Aged, 80 and over; Apoptosis; Apoptosis - physiology; Autopsy; Biological and medical sciences; Biomarkers - metabolism; Cardiology. Vascular system; Case-Control Studies; Caspase 3; Caspases - metabolism; Coronary heart disease; Coronary Stenosis - metabolism; Coronary Stenosis - pathology; Cyclo‐oxygenase‐2; Female; Heart; Humans; Hypoxia‐inducible factor‐1; Immunohistochemistry; In Situ Nick-End Labeling; Ischaemia; Male; Medical sciences; Myocardial infarction; Myocardial Infarction - pathology; Myocardial Ischemia - metabolism; Myocardial Ischemia - pathology; Myocarditis. Cardiomyopathies; Myocytes, Cardiac - pathology; Remodelling; Ventricular Remodeling - physiology; Myocardial infarction; Cyclo-oxygenase-2; Ischaemia; Remodelling; Enzyme; Biological marker; Cardiovascular disease; Myocardial disease; Phlebology; Hypoxia-inducible factor-1; Oxygenase; Tissue; Ischemia; Heart disease; Transcription factor HIF1; Oxidoreductases; Circulatory system; Artery occlusion; Cardiology; Apoptosis

Aims Unfavourable cardiac remodelling often complicates acute myocardial infarction (AMI) as a result of increased cardiomyocyte apoptosis. It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium. Methods...