Activation of Early Adenovirus Transcription by the Herpesvirus Immediate Early Gene: Evidence for a Common Cellular Control Factor

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 79; no. 16; pp. 4952 - 4956
• Main Authors: Feldman, Lawrence T., Imperiale, Michael J., Nevins, Joseph R.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.08.1982; National Acad Sciences
• Subjects: Adenoviruses; Adenoviruses, Human - genetics; Coinfection; Gene expression; Gene Expression Regulation; Genes; Genes, Viral; HeLa cells; Herpesviridae; Herpesvirus 1, Suid - genetics; Immediate early genes; Infections; Species Specificity; Suid herpesvirus 1; Transcription, Genetic; Viral Proteins - genetics; Viruses

Adenovirus mutants carrying a defective E1A gene, such as dl312, are unable to express any of the early viral genes upon infection of HeLa cells. However, efficient expression of the other early adenovirus genes was obtained when dl312-infected HeLa cells were coinfected with pseudorabies virus, a h...