AKAP3 degradation in sperm capacitation is regulated by its tyrosine phosphorylation

• Published in: Biochimica et biophysica acta Vol. 1850; no. 9; pp. 1912 - 1920
• Main Authors: Vizel, Ruth, Hillman, Pnina, Ickowicz, Debby, Breitbart, Haim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: A Kinase Anchor Proteins - metabolism; Acrosome reaction; adenosine triphosphate; AKAP3; ammonium chloride; Animals; antibodies; antimycin A; bicarbonates; Capacitation; Cattle; contraceptives; Cyclic AMP-Dependent Protein Kinases - physiology; Degradation; Male; males; mammals; mitochondria; Phosphorylation; precipitin tests; proteins; sodium; Sperm; Sperm Capacitation; sperm motility; spermatozoa; starvation; tyrosine; Tyrosine - metabolism; Western blotting; Degradation; Capacitation; Acrosome reaction; Sperm; AKAP3

The A-kinase anchoring protein (AKAP) family is essential for sperm motility, capacitation and the acrosome reaction. PKA-dependent protein tyrosine phosphorylation occurs in mammalian sperm capacitation including AKAP3. In a recent study, we showed that AKAP3 undergoes degradation under capacitatio...