Physical mechanism for inactivation of metallo-enzymes by characteristic X-rays

• Published in: International journal of radiation biology and related studies in physics, chemistry and medicine Vol. 50; no. 4; p. 665
• Main Authors: Jawad, H H, Watt, D E
• Format: Journal Article
• Language: English
• Published: England 1986
• Subjects: Dihydroorotate Oxidase - radiation effects; Metalloproteins - radiation effects; Oxidoreductases - radiation effects

Measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic X-rays at energies above and below the K absorption edge of the constituent iron atom. From the dose-survival curves and knowledge of the equilibrium electron spectrum gen...