Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

• Published in: Nature chemical biology Vol. 8; no. 7; pp. 661 - 668
• Main Authors: Rillahan, Cory D, Antonopoulos, Aristotelis, Lefort, Craig T, Sonon, Roberto, Azadi, Parastoo, Ley, Klaus, Dell, Anne, Haslam, Stuart M, Paulson, James C
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2012; Nature Publishing Group
• Subjects: 631/92/1643; 631/92/221; 631/92/96; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Carbohydrate Metabolism; Cell Biology; Cellular biology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Enzyme Inhibitors - pharmacology; Enzymes; Fucose - metabolism; Fucosyltransferases - antagonists & inhibitors; Inhibitors; Leukocytes; Mammals; Metabolism; Pharmacology; Physiology; Sialyltransferases - antagonists & inhibitors; Substrates

Fluorinated, cell-permeable analogs of sialic acid and fucose are processed by monosaccharide salvage pathways to generate sialyl- and fucosyltransferase inhibitors intracellularly. These compounds serve as important new tools to dissect the role of glycan modifications within complex biological sys...