Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 11; pp. 2433 - 2440
• Main Authors: Tobe, Ryuta, Mihara, Hisaaki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: adenosine triphosphate; biophysics; biosynthesis; cysteine; Escherichia; Selenide; selenium; Selenium delivery protein; Selenium metabolism; selenocysteine; Selenopersulfide; Selenophosphate synthetase; Selenoprotein biosynthesis; selenoproteins; thioredoxins; toxicity; transfer RNA; Selenide; EcSPS; O2; Selenopersulfide; CysDS; GSSeH; Grx; Sec; GSSeSG; Selenoprotein biosynthesis; SPS; SeM; Selenophosphate synthetase; Selenium metabolism; SCLY; Trx; GSH; Selenium delivery protein; Se0; TrxR

Selenophosphate, the key selenium donor for the synthesis of selenoprotein and selenium-modified tRNA, is produced by selenophosphate synthetase (SPS) from ATP, selenide, and H2O. Although free selenide can be used as the in vitro selenium substrate for selenophosphate synthesis, the precise physiol...