Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 9; pp. 1398 - 1409
• Main Authors: Nakamura, Toshitaka, Naguro, Isao, Ichijo, Hidenori
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019
• Subjects: Apoptosis; Apoptosis signal-regulating kinase 1 (ASK1); Cancer; catalytic activity; Cell Death; Cellular Senescence; cytotoxicity; Ferroptosis; Homeostasis; human diseases; Humans; Iron; Iron - metabolism; lipids; mitogen-activated protein kinase; necrosis; neoplasms; organelles; Oxidative Stress; reactive oxygen species; Reactive oxygen species (ROS); Reactive Oxygen Species - metabolism; Senescence; Signal Transduction; therapeutics; Ferroptosis; Senescence; Iron; Apoptosis signal-regulating kinase 1 (ASK1); Reactive oxygen species (ROS); Cancer

Iron is essential for many types of biological processes. However, excessive iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron-dependent regulated form of necrosis, was recently discovered, iron and iron-catalysed oxidative stress have attracted much interest b...