Controlling for premorbid brain size in imaging studies: T1-derived cranium scaling factor vs. T2-derived intracranial vault volume

• Published in: Psychiatry research Vol. 131; no. 2; pp. 169 - 176
• Main Authors: Fein, George, Di Sclafani, Victoria, Taylor, Colin, Moon, Kirk, Barakos, Jerome, Tran, Hoang, Landman, Bennett, Shumway, Robert
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.07.2004; Elsevier
• Subjects: Adult; Age Factors; Aged; Alcoholism - pathology; Atrophy; Biological and medical sciences; Black or African American; Black People; Brain - pathology; Brain atrophy; Cocaine-Related Disorders - pathology; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Intracranial vault; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Mathematical Computing; Medical sciences; Middle Aged; Nervous system; Premorbid brain size; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; SIENAX; Skull - pathology; White People; SIENAX; Intracranial vault; Premorbid brain size; Brain atrophy; Human; Intracranial; Central nervous system; Nuclear magnetic resonance imaging; Ethnic group; Encephalon; Investigation method; Morphology; Developmental stage; Sexual dimorphism; Vault; Morphometry; Age; Comparative study

Intracranial vault (ICV) volume, obtained from T2-weighted magnetic resonance imaging (MRI), is generally used to estimate premorbid brain size in imaging studies. T1-weighted sequences lack the signal characteristics for ICV measurements [they have poor contrast at the outer boundary of sulcal cran...