Inhibition of acid-sensing ion channels reduces the hypothalamus-pituitary-adrenal axis activity and ameliorates depression-like behavior in rats

• Published in: RSC advances Vol. 9; no. 16; pp. 877 - 8713
• Main Authors: Zhou, Wenjie, Ye, Shandong, Luo, Rong, Wu, Li-Min, Wang, Wei
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 15.03.2019; The Royal Society of Chemistry
• Subjects: antagonists; Antidepressants; blood serum; Chemistry; corticosterone; corticotropin; Elevation; Hypothalamus; Ion channels; Mental depression; Nervous system; rats; Signs and symptoms

Depression is the leading cause of disability worldwide, and its treatment represents a major clinical challenge. The hypothalamus-pituitary-adrenal (HPA) axis has been known to play a crucial role in depression and serves as a target for antidepressants. Acid-sensing ion channels (ASICs) are widely...