Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 10; pp. 2479 - 2484
• Main Authors: Furukawa, Koichi, Ohmi, Yuhsuke, Ji, Shuting, Zhang, Pu, Bhuiyan, Robiul H., Ohkawa, Yuki, Tajima, Orie, Hashimoto, Noboru, Furukawa, Keiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: adipocytes; Animals; Astrocyte; Complement; Complement System Proteins - genetics; Complement System Proteins - metabolism; energy; Ganglioside; gangliosides; Gangliosides - metabolism; Gene Expression Regulation, Neoplastic; gene targeting; genetic background; genetically modified organisms; Glioma; Glioma - genetics; Glioma - metabolism; Glioma - pathology; glycosyltransferases; Humans; hypothalamus; Inflammation; Knockout; knockout mutants; leptin; Leptin - genetics; Leptin - metabolism; leptin receptors; Membrane Microdomains - chemistry; Membrane Microdomains - metabolism; Membrane Microdomains - pathology; metabolism; Mice; Mice, Knockout; N-Acetylgalactosaminyltransferases - deficiency; N-Acetylgalactosaminyltransferases - genetics; Neoplasms, Nerve Tissue - genetics; Neoplasms, Nerve Tissue - metabolism; Neoplasms, Nerve Tissue - pathology; Nerve Tissue - metabolism; Nerve Tissue - pathology; Neurodegeneration; neurodegenerative diseases; neurons; Neurons - metabolism; Neurons - pathology; patients; phenotype; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; secretion; Sialyltransferases - deficiency; Sialyltransferases - genetics; Ganglioside; Glioma; Neurodegeneration; Inflammation; Complement; Astrocyte; Knockout
• ISSN: 0304-4165; 1872-8006
• DOI: 10.1016/j.bbagen.2017.06.007

Gene knockout mice of glycosyltransferases have clearly showed roles of their products in the bodies, while there are examples where phenotype of knockout was much less severe than expected probably due to functional redundancy. The most striking novel finding obtained from ganglioside-deficient mic...