miR-18a induces myotubes atrophy by down-regulating IgfI

• Published in: The international journal of biochemistry & cell biology Vol. 90; pp. 145 - 154
• Main Authors: Liu, Chuncheng, Wang, Meng, Chen, Min, Zhang, Kuo, Gu, Lijie, Li, Qiuyan, Yu, Zhengquan, Li, Ning, Meng, Qingyong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2017
• Subjects: Animals; Atrophy; Base Sequence; Cell Line; Down-Regulation - genetics; hypertrophy; Igf1; Insulin-Like Growth Factor I - genetics; Mice; MicroRNAs - genetics; miR-18a; Muscle Fibers, Skeletal - metabolism; muscle physiology; muscles; muscular atrophy; Muscular Atrophy - genetics; myoblasts; Myotubes; phosphorylation; postnatal development; protein degradation; protein synthesis; skeletal muscle; Atrophy; MYHC; Myotubes; CTSL; MuRF1; Igf1; miR-18a

•Overexpression of miR-18a induces myotubes atrophy and increases the expression of MuRF1, Atrogin-1 and CTSL.•And the phosphorylation of both Akt and FoxO3 are both inhibited by miR-18a, well an inhibitor of the PI3K/Akt pathway blocks the function of miR-18a.•An analysis of miR-18a targets reveals...