Differential Glycosylation Levels in Saliva from Patients with Lung or Breast Cancer: A Preliminary Assessment for Early Diagnostic Purposes

• Published in: Metabolites Vol. 11; no. 9; p. 566
• Main Authors: Ragusa, Andrea, Romano, Pietrina, Lenucci, Marcello Salvatore, Civino, Emanuela, Vergara, Daniele, Pitotti, Elena, Neglia, Cosimo, Distante, Alessandro, Romano, Giampiero Diego, Di Renzo, Nicola, Surico, Giammarco, Piscitelli, Prisco, Maffia, Michele
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.08.2021; MDPI
• Subjects: Anion-exchange chromatography; Biomarkers; Biopsy; Body mass index; Breast cancer; Cancer therapies; Carbohydrates; Cell adhesion; Chromatography; Clinical medicine; D-Galactosamine; early diagnosis; Galactose; Glucosamine; glycomics; glycoprotein; Glycoproteins; Glycosylation; HPEAC-PAD; Lung cancer; Mannose; Medical prognosis; Mortality; Patients; Polysaccharides; Proteins; Saliva; Statistical analysis

Glycans play a fundamental role in several biological processes, such as cell–cell adhesion, signaling, and recognition. Similarly, abnormal glycosylation is involved in many pathological processes, among which include tumor growth and progression. Several highly glycosylated proteins found in blood...