Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment

• Published in: Biomedicine & pharmacotherapy Vol. 162; p. 114688
• Main Authors: Wang, Yuxiao, Li, Jiaxin, Tang, Maomao, Peng, Chengjun, Wang, Guichun, Wang, Jingjing, Wang, Xinrui, Chang, Xiangwei, Guo, Jian, Gui, Shuangying
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2023
• Subjects: Drug Delivery Systems; Drug Liberation; Humans; Hydrogels; Periodontitis; Periodontitis - drug therapy; Smart hydrogel; Stimuli-responsive; Temperature; EDC; PND; TC-PCM@GNC-PND; MZ@PNM; DPSC-Exos/CS; GOx; DZIF; Pg; UV; HGF; PMNT; Stimuli-responsive; PF-127; Gel; MMP; Periodontitis; ROS; LCST; GNC; Met; PTB; Aa; Drug delivery systems; BMSC; GelMA-Z; G; SDF-1; UCST; β-GP; PDLLA; PDA; LPS; S. aureus; p-CM; DZIF@PGel; NHS; GelMA; E. coli; AGE; PBA-PEI/OD; Col; GelMA–RF; Bf; BIO; MSN; MZ@PNM@GCP; CM; Smart hydrogel; TA; CS; RIG; ZIF-8; NIR; GelMA-AuNBPs@SiO2; HA; PVA; HE

Periodontitis is a chronic inflammatory disease initiated by pathogenic biofilms and host immunity that damages tooth-supporting tissues, including the gingiva, periodontal ligament and alveolar bone. The physiological functions of the oral cavity, such as saliva secretion and chewing, greatly reduc...