The regulation of AβPP expression by RNA-binding proteins
► Multiple RBPs interact with distinct cis-elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis-elements and mediate message stability. ► IRP1 binds to an IRE in the 5′-UTR of APP mRNA to regulate translation. ► FMRP and hnRNP C compete for binding to a CR G-rich element to modulate tran...
Saved in:
| Published in | Ageing research reviews Vol. 11; no. 4; pp. 450 - 459 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
01.09.2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1568-1637 1872-9649 1872-9649 |
| DOI | 10.1016/j.arr.2012.03.005 |
Cover
Loading…
| Abstract | ► Multiple RBPs interact with distinct cis-elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis-elements and mediate message stability. ► IRP1 binds to an IRE in the 5′-UTR of APP mRNA to regulate translation. ► FMRP and hnRNP C compete for binding to a CR G-rich element to modulate translation. ► APP mRNA is subject to diverse post-transcriptional regulatory processes.
Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis. |
|---|---|
| AbstractList | Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis.Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis. ► Multiple RBPs interact with distinct cis-elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis-elements and mediate message stability. ► IRP1 binds to an IRE in the 5′-UTR of APP mRNA to regulate translation. ► FMRP and hnRNP C compete for binding to a CR G-rich element to modulate translation. ► APP mRNA is subject to diverse post-transcriptional regulatory processes. Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis. Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer's disease (AD) and Down syndrome (Masters et al., 1985). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis. Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques associated with Alzheimer’s disease (AD) and Down syndrome ( Masters et al., 1985 ). Intense investigation by the scientific community has centered on understanding the molecular pathways that underlie the production and accumulation of Aβ Therapeutics that reduce the levels of this tenacious, plaque-promoting peptide may reduce the ongoing neural dysfunction and neuronal degeneration that occurs so profoundly in AD. AβPP and Aβ production are highly complex and involve still to be elucidated combinations of transcriptional, post-transcriptional, translational and post-translational events that mediate the production, processing and clearance of these proteins. Research in our laboratory for the past two decades has focused on the role of RNA binding proteins (RBPs) in mediating the post-transcriptional as well as translational regulation of APP messenger RNA (mRNA). This review article summarizes our findings, as well as those from other laboratories, describing the identification of regulatory RBPs, where and under what conditions they interact with APP mRNA and how those interactions control AβPP and Aβ synthesis. Highlights ► Multiple RBPs interact with distinct cis -elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis -elements and mediate message stability. ► IRP1 binds to an IRE in the 5′-UTR of APP mRNA to regulate translation. ► FMRP and hnRNP C compete for binding to a CR G-rich element to modulate translation. ► APP mRNA is subject to diverse post-transcriptional regulatory processes. |
| Author | Malter, James S. Westmark, Cara J. |
| AuthorAffiliation | 1 University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705 USA, westmark@wisc.edu , Phone: 262-9730 2 University of Texas Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, James.Malter@UTSouthwestern.edu , Phone: 648-4020 |
| AuthorAffiliation_xml | – name: 1 University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705 USA, westmark@wisc.edu , Phone: 262-9730 – name: 2 University of Texas Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, James.Malter@UTSouthwestern.edu , Phone: 648-4020 |
| Author_xml | – sequence: 1 givenname: Cara J. surname: Westmark fullname: Westmark, Cara J. email: westmark@wisc.edu organization: University of Wisconsin, Waisman Center for Developmental Disabilities, 1500 Highland Avenue, Madison, WI 53705, USA – sequence: 2 givenname: James S. surname: Malter fullname: Malter, James S. email: James.Malter@UTSouthwestern.edu organization: University of Texas Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22504584$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1DAUhS1URH_gAdigLNkkXP_kjwXSqCoFqYIKyvrKcW6mHjL2YCcV81p9EJ4JD50iQKIb27Lv-Y58zjE7cN4RY885FBx49WpV6BAKAVwUIAuA8hE74k0t8rZS7UE6l1WT80rWh-w4xhUkTVuJJ-xQiBJU2agj9vrqmrJAy3nUk_Uu80O2-HF7eZnR902gGHd33Tb79GGRd9b11i2zTfATWRefsseDHiM92-8n7Mvbs6vTd_nFx_P3p4uL3KiKT7keRCm5pk6CajQXShrTCy06oL5VQ9c1XEIP1dAIorYs67QY3emy4tBT18gT9uaOu5m7NfWG3BT0iJtg1zps0WuLf784e41Lf4NSgUifT4CXe0Dw32aKE65tNDSO2pGfI3KoVd0Ab2QaffGn12-T-8DSQH03YIKPMdCAxk6_okvWdkws3FWDK0zV4K4aBImpmqTk_yjv4Q9p9l-nlO-NpYBmtM4aPX6lLcWVn4NL0SPHmDT4eVf4rm8uAEC1bQK0_wdg7-0D5j8BeXK7Yw |
| CitedBy_id | crossref_primary_10_1007_s12035_015_9229_8 crossref_primary_10_3389_fnmol_2016_00147 crossref_primary_10_3390_cells11213421 crossref_primary_10_1371_journal_pone_0103365 crossref_primary_10_3389_fragi_2021_721579 crossref_primary_10_1007_s12035_018_1344_x crossref_primary_10_1179_1476830513Z_000000000112 crossref_primary_10_1038_mp_2012_122 crossref_primary_10_1038_s41598_020_66394_y crossref_primary_10_1007_s12035_017_0820_z crossref_primary_10_1186_1756_6606_7_40 crossref_primary_10_3389_fragi_2023_1164057 crossref_primary_10_3389_fnins_2018_00533 crossref_primary_10_1128_jvi_00858_24 crossref_primary_10_1002_biof_1207 crossref_primary_10_1186_s12952_016_0065_9 crossref_primary_10_1371_journal_pone_0143160 |
| Cites_doi | 10.1128/MCB.19.12.7925 10.1128/MCB.14.12.7984 10.1074/jbc.270.47.28297 10.1016/0006-8993(92)91697-D 10.1074/jbc.M006538200 10.1128/MCB.23.1.280-288.2003 10.1006/mcne.2000.0834 10.1073/pnas.0507596102 10.4049/jimmunol.167.10.5970 10.1093/cercor/10.10.1038 10.1038/nrn1667 10.1172/JCI9075 10.1038/sj.emboj.7600824 10.1038/nsmb.1815 10.1073/pnas.82.12.4245 10.1093/nar/17.16.6625 10.1016/S0169-328X(99)00158-8 10.1126/science.1078259 10.1074/jbc.M009435200 10.1097/00004714-198204000-00010 10.1159/000090366 10.1128/MCB.15.4.2219 10.1074/jbc.272.16.10870 10.1073/pnas.83.6.1670 10.1074/jbc.270.29.17292 10.1074/jbc.273.30.19025 10.1093/hmg/11.24.3007 10.1523/JNEUROSCI.16-22-07171.1996 10.1128/MCB.20.23.9084-9091.2000 10.1523/JNEUROSCI.19-18-07793.1999 10.1074/jbc.M110.149161 10.1073/pnas.81.23.7471 10.1055/s-0037-1613396 10.1074/jbc.270.10.4983 10.1101/gad.7.9.1725 10.1016/S0021-9258(18)52955-0 10.1016/j.tins.2004.04.009 10.1038/sj.leu.2400975 10.1074/jbc.273.43.28057 10.2174/156720510791050957 10.1523/JNEUROSCI.4337-04.2005 10.1016/j.neuron.2006.10.028 10.1016/j.neurobiolaging.2006.03.003 10.1038/78682 10.1073/pnas.85.19.7322 10.1146/annurev-pathol-011811-132457 10.1093/emboj/17.5.1476 10.1093/nar/29.11.2276 10.1038/sj.emboj.7600954 10.1128/MCB.20.16.5947-5959.2000 10.1128/MCB.10.12.6397 10.1074/jbc.M207435200 10.1091/mbc.E08-06-0562 10.1093/nar/gkl409 10.1128/MCB.11.5.2460 10.1016/j.ceb.2009.03.005 10.1371/journal.pbio.0040210 10.1126/science.3952495 10.1093/hmg/10.4.329 10.1016/j.bbaexp.2005.08.005 10.1016/S0169-328X(01)00112-7 10.1016/S0021-9258(19)51038-9 10.1111/j.1432-1033.1988.tb14224.x 10.1517/14728222.2010.525352 10.1074/jbc.M704629200 10.1038/329489a0 10.1002/jnr.10876 10.1016/S0006-291X(03)00766-6 10.4049/jimmunol.173.2.976 10.1523/JNEUROSCI.2306-04.2004 10.1016/S1097-2765(01)00329-X 10.1016/S0092-8674(01)00568-2 10.1073/pnas.122205699 10.1016/S0092-8674(01)00566-9 10.1002/j.1460-2075.1992.tb05382.x 10.1016/j.molcel.2007.02.011 10.1016/S0092-8674(03)00079-5 10.1017/S135583820101994X 10.1016/S0306-4522(03)00406-8 10.1128/MCB.17.6.3028 10.1371/journal.pbio.0050052 10.1002/jnr.490420305 10.1046/j.1471-4159.2000.0740052.x 10.1002/j.1460-2075.1991.tb07715.x 10.1016/0014-4827(88)90397-7 10.1016/0378-1119(95)00207-M 10.1016/j.bbrc.2010.12.053 10.1074/jbc.M309111200 10.2174/092986711798194351 10.1016/S0021-9258(18)49970-X 10.1016/j.neulet.2005.04.040 10.1016/j.neurobiolaging.2008.02.011 10.1074/jbc.274.10.6421 10.1074/jbc.M002354200 10.1186/1750-1326-3-10 10.1016/0092-8674(86)90341-7 10.1101/gad.1276805 10.1128/MCB.14.9.6068 10.1016/0092-8674(89)90241-9 10.1128/MCB.05587-11 10.1101/gad.14.10.1236 10.4161/cib.3.6.13172 10.1074/jbc.270.47.28257 10.1128/MCB.19.6.4311 10.1016/0003-9861(91)90161-B 10.1126/science.2814487 10.1371/journal.pone.0026549 10.1016/S0169-328X(03)00027-5 10.1523/JNEUROSCI.22-15-06331.2002 10.1038/415462a 10.1093/nar/26.14.3418 10.1016/S0021-9258(19)51039-0 10.1091/mbc.E09-01-0035 10.1099/0022-1317-80-10-2629 10.1038/nrm2080 10.1016/S0896-6273(03)00034-5 |
| ContentType | Journal Article |
| Copyright | 2012 Elsevier B.V. Elsevier B.V. Copyright © 2012 Elsevier B.V. All rights reserved. 2012 Elsevier Ireland Ltd. All rights reserved. 2012 |
| Copyright_xml | – notice: 2012 Elsevier B.V. – notice: Elsevier B.V. – notice: Copyright © 2012 Elsevier B.V. All rights reserved. – notice: 2012 Elsevier Ireland Ltd. All rights reserved. 2012 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.arr.2012.03.005 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1872-9649 |
| EndPage | 459 |
| ExternalDocumentID | PMC3402637 22504584 10_1016_j_arr_2012_03_005 1_s2_0_S1568163712000499 S1568163712000499 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIDA NIH HHS grantid: R01-DA026067 – fundername: NIA NIH HHS grantid: R01-AG10675 – fundername: NICHD NIH HHS grantid: P30-HD03352 – fundername: NIA NIH HHS grantid: R01 AG010675 – fundername: NICHD NIH HHS grantid: P30 HD003352 – fundername: NIA NIH HHS grantid: T32-AG00213 – fundername: NIA NIH HHS grantid: T32 AG000213 – fundername: NIDA NIH HHS grantid: R01 DA026067 – fundername: National Institute on Aging : NIA grantid: T32 AG000213-12 || AG – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-45 || HD – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-43S2 || HD – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-43 || HD – fundername: National Institute on Drug Abuse : NIDA grantid: R01 DA026067-01 || DA – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-39 || HD – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-40 || HD – fundername: National Institute on Aging : NIA grantid: T32 AG000213-14 || AG – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-41 || HD – fundername: National Institute of Child Health & Human Development : NICHD grantid: P30 HD003352-37 || HD |
| GroupedDBID | --- --K --M -~X .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23M 4.4 457 4G. 53G 5GY 5VS 6J9 7-5 71M 8P~ AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXUO AAYWO ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABWVN ABXDB ACDAQ ACGFO ACGFS ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX AEBSH AEFWE AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGRDE AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP AXJTR BKOJK BLXMC CS3 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM M41 MO0 N9A O-L O9- OAUVE OD~ OO0 OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UNMZH Z5R ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AAYXX AGRNS BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 EFLBG 5PM |
| ID | FETCH-LOGICAL-c461t-af2531aeb3048a1243ccd2a2b0ed94fbb8130d06f82ee9557e95caba5610deb83 |
| ISSN | 1568-1637 1872-9649 |
| IngestDate | Thu Aug 21 18:29:28 EDT 2025 Thu Sep 04 23:47:21 EDT 2025 Mon Jul 21 05:18:49 EDT 2025 Tue Jul 01 02:57:14 EDT 2025 Thu Apr 24 23:03:08 EDT 2025 Sun Feb 23 10:19:28 EST 2025 Tue Aug 26 20:09:20 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Aβ AβPP Post-transcriptional gene regulation hnRNP C FMRP Nucleolin |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2012 Elsevier B.V. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c461t-af2531aeb3048a1243ccd2a2b0ed94fbb8130d06f82ee9557e95caba5610deb83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 22504584 |
| PQID | 1074780183 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3402637 proquest_miscellaneous_1074780183 pubmed_primary_22504584 crossref_citationtrail_10_1016_j_arr_2012_03_005 crossref_primary_10_1016_j_arr_2012_03_005 elsevier_clinicalkeyesjournals_1_s2_0_S1568163712000499 elsevier_clinicalkey_doi_10_1016_j_arr_2012_03_005 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-09-01 |
| PublicationDateYYYYMMDD | 2012-09-01 |
| PublicationDate_xml | – month: 09 year: 2012 text: 2012-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Ageing research reviews |
| PublicationTitleAlternate | Ageing Res Rev |
| PublicationYear | 2012 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Shigematsu, McGeer, McGeer (bib0480) 1992; 592 Pfeifer, Boncristiano, Bondolfi, Stalder, Deller, Staufenbiel, Mathews, Jucker (bib0420) 2002; 298 Westmark, Malter (bib0540) 2007; 5 Bouvet, Diaz, Kindbeiter, Madjar, Amalric (bib0065) 1998; 273 Borer, Lehner, Eppenberger, Nigg (bib0060) 1989; 56 Panza, Frisardi, Solfrizzi, Imbimbo, Logroscino, Santamato, Greco, Seripa, Pilotto (bib0395) 2011; 18 Tuteja, Huang, Skopac, Tuteja, Hrvatic, Zhang, Pongor, Joseph, Faucher, Amalric (bib0525) 1995; 160 Denman, Potempska, Wolfe, Ramakrishna, Miller (bib0180) 1991; 288 Akao, Marukawa, Morikawa, Nakao, Kamei, Hachiya, Tsujimoto (bib0010) 1995; 55 Ginisty, Amalric, Bouvet (bib0235) 1998; 17 Westmark, Malter (bib0545) 2001; 90 Darnell, Jensen, Jin, Brown, Warren, Darnell (bib0170) 2001; 107 Westmark, Shin, Westmark, Soltaninassab, Reinke, Malter (bib0555) 2006; 27 Holcik, Gordon, Korneluk (bib0255) 2003; 23 Gillis, Malter (bib0230) 1991; 266 Parker, Sheth (bib0400) 2007; 25 Malter (bib0350) 1989; 246 Zaidi, Malter (bib0595) 1994; 269 Mazroui, Huot, Tremblay, Filion, Labelle, Khandjian (bib0360) 2002; 11 Bear, Huber, Warren (bib0050) 2004; 27 Brockstedt, Rickers, Kostka, Laubersheimer, Dorken, Wittmann-Liebold, Bommert, Otto (bib0080) 1998; 273 Mahajan, Narlikar, Boyapaty, Kingston, Weissman (bib0340) 2005; 102 Caput, Beutler, Hartog, Thayer, Brown-Shimer, Cerami (bib0105) 1986; 83 Westmark, Malter (bib0550) 2001; 276 Yang, Gong, Gong, Jiang, Kwon, Wang, Zheng, Zhang, Gan, Zhao (bib0570) 2005; 384 Pecknold, McClure, Appeltauer, Wrzesinski, Allan (bib0415) 1982; 2 Brown, Jin, Ceman, Darnell, O’Donnell, Tenenbaum, Jin, Feng, Wilkinson, Keene, Darnell, Warren (bib0085) 2001; 107 Ford, Suh, Wright, Shay (bib0220) 2000; 20 Weston, Sommerville (bib0560) 2006; 34 Rockenstein, McConlogue, Tan, Power, Masliah, Mucke (bib0445) 1995; 270 Thomson, Rogers, Leedman (bib0510) 2000; 275 Tiedge, Brosius (bib0515) 1996; 16 McLaren, Caruccio, Ross (bib0365) 1997; 17 Wilusz, Shenk (bib0565) 1990; 10 Erard, Belenguer, Caizergues-Ferrer, Pantaloni, Amalric (bib0205) 1988; 175 Stefani, Fraser, Darnell, Darnell (bib0495) 2004; 24 Lai, Carballo, Strum, Kennington, Phillips, Blackshear (bib0315) 1999; 19 Ruberti, Barbato, Cogoni (bib0460) 2010; 3 Chen, Gherzi, Andersen, Gaietta, Jurchott, Royer, Mann, Karin (bib0120) 2000; 14 Lapierre, Oyewumi (bib0320) 1982; 31 Darnell, Fraser, Mostovetsky, Stefani, Jones, Eddy, Darnell (bib0165) 2005; 19 Cox, Bawden, Martin, May (bib0160) 1991; 10 Didier, Schiffenbauer, Woulfe, Zacheis, Schwartz (bib0190) 1988; 85 Eulalio, Behm-Ansmant, Izaurralde (bib0210) 2007; 8 Bard, Cannon, Barbour, Burke, Games, Grajeda, Guido, Hu, Huang, Johnson-Wood, Khan, Kholodenko, Lee, Lieberburg, Motter, Nguyen, Soriano, Vasquez, Weiss, Welch, Seubert, Schenk, Yednock (bib0045) 2000; 6 Dolzhanskaya, Sung, Conti, Currie, Denman (bib0195) 2003; 305 Jordan (bib0280) 1987; 329 Huber, Gallagher, Warren, Bear (bib0265) 2002; 99 Chu, Rana (bib0145) 2006; 4 Cho, Cahill, Vanderburg, Scherzer, Wang, Huang, Rogers (bib0130) 2010; 285 Kim, Klausner, Rouault (bib0295) 1995; 270 Kotilinek, Bacskai, Westerman, Kawarabayashi, Younkin, Hyman, Younkin, Ashe (bib0300) 2002; 22 Zaidi, Malter (bib0585) 1995; 270 Torroja, Packard, Gorczyca, White, Budnik (bib0520) 1999; 19 Rajagopalan, Westmark, Jarzembowski, Malter (bib0435) 1998; 26 Miyashiro, Beckel-Mitchener, Purk, Becker, Barret, Liu, Carbonetto, Weiler, Greenough, Eberwine (bib0385) 2003; 37 Zaidi, Denman, Malter (bib0590) 1994; 269 Brewer (bib0075) 1991; 11 Heaton, Dlakic, Dlakic, Gelehrter (bib0250) 2001; 276 Balagopal, Parker (bib0030) 2009; 21 Malter, Ray, Westmark, Westmark (bib0345) 2010; 7 Racke, Boone, Hepburn, Parsadainian, Bryan, Ness, Piroozi, Jordan, Brown, Hoffman, Holtzman, Bales, Gitter, May, Paul, DeMattos (bib0425) 2005; 25 Ansari, Safak, Gallia, Sawaya, Amini, Khalili (bib0020) 1999; 80 Westmark, Westmark, O’Riordan, Ray, Hervey, Salamat, Abozeid, Stein, Stodola, Tranfaglia, Burger, Berry-Kravis, Malter (bib0535) 2011; 6 Sengupta, Bandyopadhyay, Fernandes, Spicer (bib0470) 2004; 279 Huang, Fu, Lin, Conner, Zhang, Aladjem (bib0260) 2011; 31 Broytman, Westmark, Gurel, Malter (bib0090) 2008; 30 Long, Lahiri (bib0335) 2011; 404 Akaaboune, Allinquant, Farza, Roy, Magoul, Fiszman, Festoff, Hantai (bib0005) 2000; 15 Coller, Tucker, Sheth, Valencia-Sanchez, Parker (bib0155) 2001; 7 Derenzini, Sirri, Trere, Ochs (bib0185) 1995; 73 Zalfa, Giorgi, Primerano, Moro, Di Penta, Reis, Oostra, Bagni (bib0600) 2003; 112 Lagnado, Brown, Goodall (bib0310) 1994; 14 Friedmann, Davis, Ciccone, Rubin (bib0225) 1980; 274 Chen, Yun, Seto, Liu, Toth (bib0125) 2003; 120 Ranjan, Tafuri, Wolffe (bib0440) 1993; 7 Shaw, Kamen (bib0475) 1986; 46 Barbee, Estes, Cziko, Hillebrand, Luedeman, Coller, Johnson, Howlett, Geng, Ueda, Brand, Newbury, Wilhelm, Levine, Nakamura, Parker, Ramaswami (bib0040) 2006; 52 Choi, Dreyfuss (bib0140) 1984; 81 Santoro, Bray, Warren (bib0465) 2012; 7 Ceman, Brown, Warren (bib0110) 1999; 19 Tanner, Linder (bib0505) 2001; 8 Rajagopalan, Malter (bib0430) 2000; 74 Belenguer, Baldin, Mathieu, Prats, Bensaid, Bouche, Amalric (bib0055) 1989; 17 Hamilton, Nagy, Malter, Arrick, Rigby (bib0240) 1993; 268 Soba, Eggert, Wagner, Zentgraf, Siehl, Kreger, Lower, Langer, Merdes, Paro, Masters, Muller, Kins, Beyreuther (bib0490) 2005; 24 Rogers, Randall, Cahill, Eder, Huang, Gunshin, Leiter, McPhee, Sarang, Utsuki, Greig, Lahiri, Tanzi, Bush, Giordano, Gullans (bib0450) 2002; 277 Stenina, Poptic, DiCorleto (bib0500) 2000; 106 Pecknold, McClure, Appeltauer (bib0410) 1980; 274 Rogers, Leiter, McPhee, Cahill, Zhan, Potter, Nilsson (bib0455) 1999; 274 Broytman, Malter (bib0095) 2004; 75 Clarke, Vasanthakumar, Anderson, Pondarre, Koh, Deck, Pitula, Epstein, Fleming, Eisenstein (bib0150) 2006; 25 Millard, Vidal, Markus, Koff (bib0370) 2000; 20 Lee, Kim, Kuwano, Abdelmohsen, Srikantan, Subaran, Gleichmann, Mughal, Martindale, Yang, Worley, Mattson, Gorospe (bib0325) 2010; 17 Yang, Tsai, Lee, Lei, Lai, Chen, Yeh, Lee (bib0575) 1994; 14 Egyhazi, Pigon, Chang, Ghaffari, Dreesen, Wellman, Case, Olson (bib0200) 1988; 178 Bouvet, Matsumoto, Wolffe (bib0070) 1995; 270 Wang, Hoyle, McCubrey (bib0530) 1998; 12 Irwin, Galvez, Greenough (bib0275) 2000; 10 Morgan (bib0390) 2005; 2 Inamura, Hoshino, Uchiumi, Nawa, Takei (bib0270) 2003; 111 Bandyopadhyay, Huang, Lahiri, Rogers (bib0035) 2010; 14 Masters, Simms, Weinman, Multhaup, McDonald, Beyreuther (bib0355) 1985; 82 Check (bib0115) 2002; 415 Amara, Junaid, Clough, Liang (bib0015) 1999; 71 Singh, Laughlin, Kosinski, Covey (bib0485) 2004; 173 Capowski, Esnault, Bhattacharya, Malter (bib0100) 2001; 167 Patel, Hoang, Miller, Ansaloni, Huang, Rogers, Lee, Saunders (bib0405) 2008; 3 Minshall, Reiter, Weil, Standart (bib0380) 2007; 282 Khacho, Mekhail, Pilon-Larose, Pause, Cote, Lee (bib0285) 2008; 19 Minshall, Kress, Weil, Standart (bib0375) 2009; 20 Li, Zhang, Ku, Wilkinson, Warren, Feng (bib0330) 2001; 29 Heaton, Dlakic, Gelehrter (bib0245) 2003; 89 Kibbey, Johnson, Petryshyn, Jucker, Kleinman (bib0290) 1995; 42 Yurkova, Murray (bib0580) 1997; 272 de Sauvage, Kruys, Marinx, Huez, Octave (bib0175) 1992; 11 Bagni, Greenough (bib0025) 2005; 6 Zubiaga, Belasco, Greenberg (bib0605) 1995; 15 Laggerbauer, Ostareck, Keidel, Ostareck-Lederer, Fischer (bib0305) 2001; 10 Choi, Grabowski, Sharp, Dreyfuss (bib0135) 1986; 231 Fahling, Steege, Perlewitz, Nafz, Mrowka, Persson, Thiele (bib0215) 2005; 1731 Morgan (10.1016/j.arr.2012.03.005_bib0390) 2005; 2 Didier (10.1016/j.arr.2012.03.005_bib0190) 1988; 85 Belenguer (10.1016/j.arr.2012.03.005_bib0055) 1989; 17 Lee (10.1016/j.arr.2012.03.005_bib0325) 2010; 17 Huber (10.1016/j.arr.2012.03.005_bib0265) 2002; 99 Jordan (10.1016/j.arr.2012.03.005_bib0280) 1987; 329 Brown (10.1016/j.arr.2012.03.005_bib0085) 2001; 107 Dolzhanskaya (10.1016/j.arr.2012.03.005_bib0195) 2003; 305 Friedmann (10.1016/j.arr.2012.03.005_bib0225) 1980; 274 Holcik (10.1016/j.arr.2012.03.005_bib0255) 2003; 23 Stefani (10.1016/j.arr.2012.03.005_bib0495) 2004; 24 Weston (10.1016/j.arr.2012.03.005_bib0560) 2006; 34 Westmark (10.1016/j.arr.2012.03.005_bib0535) 2011; 6 Erard (10.1016/j.arr.2012.03.005_bib0205) 1988; 175 Westmark (10.1016/j.arr.2012.03.005_bib0550) 2001; 276 Capowski (10.1016/j.arr.2012.03.005_bib0100) 2001; 167 Heaton (10.1016/j.arr.2012.03.005_bib0250) 2001; 276 Choi (10.1016/j.arr.2012.03.005_bib0140) 1984; 81 Chu (10.1016/j.arr.2012.03.005_bib0145) 2006; 4 Wang (10.1016/j.arr.2012.03.005_bib0530) 1998; 12 Tiedge (10.1016/j.arr.2012.03.005_bib0515) 1996; 16 de Sauvage (10.1016/j.arr.2012.03.005_bib0175) 1992; 11 Bagni (10.1016/j.arr.2012.03.005_bib0025) 2005; 6 Brewer (10.1016/j.arr.2012.03.005_bib0075) 1991; 11 Akaaboune (10.1016/j.arr.2012.03.005_bib0005) 2000; 15 Malter (10.1016/j.arr.2012.03.005_bib0345) 2010; 7 Broytman (10.1016/j.arr.2012.03.005_bib0095) 2004; 75 Pfeifer (10.1016/j.arr.2012.03.005_bib0420) 2002; 298 Ansari (10.1016/j.arr.2012.03.005_bib0020) 1999; 80 Singh (10.1016/j.arr.2012.03.005_bib0485) 2004; 173 Gillis (10.1016/j.arr.2012.03.005_bib0230) 1991; 266 Chen (10.1016/j.arr.2012.03.005_bib0125) 2003; 120 Lapierre (10.1016/j.arr.2012.03.005_bib0320) 1982; 31 Darnell (10.1016/j.arr.2012.03.005_bib0165) 2005; 19 Yang (10.1016/j.arr.2012.03.005_bib0575) 1994; 14 Pecknold (10.1016/j.arr.2012.03.005_bib0415) 1982; 2 Balagopal (10.1016/j.arr.2012.03.005_bib0030) 2009; 21 Clarke (10.1016/j.arr.2012.03.005_bib0150) 2006; 25 Fahling (10.1016/j.arr.2012.03.005_bib0215) 2005; 1731 Stenina (10.1016/j.arr.2012.03.005_bib0500) 2000; 106 Darnell (10.1016/j.arr.2012.03.005_bib0170) 2001; 107 Rajagopalan (10.1016/j.arr.2012.03.005_bib0430) 2000; 74 Kim (10.1016/j.arr.2012.03.005_bib0295) 1995; 270 Denman (10.1016/j.arr.2012.03.005_bib0180) 1991; 288 Kotilinek (10.1016/j.arr.2012.03.005_bib0300) 2002; 22 Patel (10.1016/j.arr.2012.03.005_bib0405) 2008; 3 Shigematsu (10.1016/j.arr.2012.03.005_bib0480) 1992; 592 Borer (10.1016/j.arr.2012.03.005_bib0060) 1989; 56 Masters (10.1016/j.arr.2012.03.005_bib0355) 1985; 82 Kibbey (10.1016/j.arr.2012.03.005_bib0290) 1995; 42 Minshall (10.1016/j.arr.2012.03.005_bib0380) 2007; 282 Hamilton (10.1016/j.arr.2012.03.005_bib0240) 1993; 268 Lai (10.1016/j.arr.2012.03.005_bib0315) 1999; 19 McLaren (10.1016/j.arr.2012.03.005_bib0365) 1997; 17 Parker (10.1016/j.arr.2012.03.005_bib0400) 2007; 25 Coller (10.1016/j.arr.2012.03.005_bib0155) 2001; 7 Yurkova (10.1016/j.arr.2012.03.005_bib0580) 1997; 272 Sengupta (10.1016/j.arr.2012.03.005_bib0470) 2004; 279 Minshall (10.1016/j.arr.2012.03.005_bib0375) 2009; 20 Soba (10.1016/j.arr.2012.03.005_bib0490) 2005; 24 Zaidi (10.1016/j.arr.2012.03.005_bib0595) 1994; 269 Ginisty (10.1016/j.arr.2012.03.005_bib0235) 1998; 17 Panza (10.1016/j.arr.2012.03.005_bib0395) 2011; 18 Yang (10.1016/j.arr.2012.03.005_bib0570) 2005; 384 Rogers (10.1016/j.arr.2012.03.005_bib0450) 2002; 277 Westmark (10.1016/j.arr.2012.03.005_bib0540) 2007; 5 Zaidi (10.1016/j.arr.2012.03.005_bib0585) 1995; 270 Long (10.1016/j.arr.2012.03.005_bib0335) 2011; 404 Bear (10.1016/j.arr.2012.03.005_bib0050) 2004; 27 Bouvet (10.1016/j.arr.2012.03.005_bib0065) 1998; 273 Pecknold (10.1016/j.arr.2012.03.005_bib0410) 1980; 274 Inamura (10.1016/j.arr.2012.03.005_bib0270) 2003; 111 Derenzini (10.1016/j.arr.2012.03.005_bib0185) 1995; 73 Bard (10.1016/j.arr.2012.03.005_bib0045) 2000; 6 Ceman (10.1016/j.arr.2012.03.005_bib0110) 1999; 19 Cox (10.1016/j.arr.2012.03.005_bib0160) 1991; 10 Wilusz (10.1016/j.arr.2012.03.005_bib0565) 1990; 10 Barbee (10.1016/j.arr.2012.03.005_bib0040) 2006; 52 Rajagopalan (10.1016/j.arr.2012.03.005_bib0435) 1998; 26 Amara (10.1016/j.arr.2012.03.005_bib0015) 1999; 71 Lagnado (10.1016/j.arr.2012.03.005_bib0310) 1994; 14 Akao (10.1016/j.arr.2012.03.005_bib0010) 1995; 55 Ranjan (10.1016/j.arr.2012.03.005_bib0440) 1993; 7 Caput (10.1016/j.arr.2012.03.005_bib0105) 1986; 83 Li (10.1016/j.arr.2012.03.005_bib0330) 2001; 29 Torroja (10.1016/j.arr.2012.03.005_bib0520) 1999; 19 Heaton (10.1016/j.arr.2012.03.005_bib0245) 2003; 89 Broytman (10.1016/j.arr.2012.03.005_bib0090) 2008; 30 Rockenstein (10.1016/j.arr.2012.03.005_bib0445) 1995; 270 Santoro (10.1016/j.arr.2012.03.005_bib0465) 2012; 7 Malter (10.1016/j.arr.2012.03.005_bib0350) 1989; 246 Westmark (10.1016/j.arr.2012.03.005_bib0555) 2006; 27 Bouvet (10.1016/j.arr.2012.03.005_bib0070) 1995; 270 Khacho (10.1016/j.arr.2012.03.005_bib0285) 2008; 19 Rogers (10.1016/j.arr.2012.03.005_bib0455) 1999; 274 Tanner (10.1016/j.arr.2012.03.005_bib0505) 2001; 8 Ford (10.1016/j.arr.2012.03.005_bib0220) 2000; 20 Mazroui (10.1016/j.arr.2012.03.005_bib0360) 2002; 11 Zubiaga (10.1016/j.arr.2012.03.005_bib0605) 1995; 15 Mahajan (10.1016/j.arr.2012.03.005_bib0340) 2005; 102 Chen (10.1016/j.arr.2012.03.005_bib0120) 2000; 14 Millard (10.1016/j.arr.2012.03.005_bib0370) 2000; 20 Racke (10.1016/j.arr.2012.03.005_bib0425) 2005; 25 Thomson (10.1016/j.arr.2012.03.005_bib0510) 2000; 275 Ruberti (10.1016/j.arr.2012.03.005_bib0460) 2010; 3 Huang (10.1016/j.arr.2012.03.005_bib0260) 2011; 31 Miyashiro (10.1016/j.arr.2012.03.005_bib0385) 2003; 37 Zaidi (10.1016/j.arr.2012.03.005_bib0590) 1994; 269 Zalfa (10.1016/j.arr.2012.03.005_bib0600) 2003; 112 Egyhazi (10.1016/j.arr.2012.03.005_bib0200) 1988; 178 Laggerbauer (10.1016/j.arr.2012.03.005_bib0305) 2001; 10 Eulalio (10.1016/j.arr.2012.03.005_bib0210) 2007; 8 Shaw (10.1016/j.arr.2012.03.005_bib0475) 1986; 46 Bandyopadhyay (10.1016/j.arr.2012.03.005_bib0035) 2010; 14 Brockstedt (10.1016/j.arr.2012.03.005_bib0080) 1998; 273 Cho (10.1016/j.arr.2012.03.005_bib0130) 2010; 285 Westmark (10.1016/j.arr.2012.03.005_bib0545) 2001; 90 Choi (10.1016/j.arr.2012.03.005_bib0135) 1986; 231 Tuteja (10.1016/j.arr.2012.03.005_bib0525) 1995; 160 Check (10.1016/j.arr.2012.03.005_bib0115) 2002; 415 Irwin (10.1016/j.arr.2012.03.005_bib0275) 2000; 10 |
| References_xml | – volume: 246 start-page: 664 year: 1989 end-page: 666 ident: bib0350 article-title: Identification of an AUUUA-specific messenger RNA binding protein publication-title: Science – volume: 2 start-page: 129 year: 1982 end-page: 133 ident: bib0415 article-title: Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study publication-title: Journal of Clinical Psychopharmacology – volume: 99 start-page: 7746 year: 2002 end-page: 7750 ident: bib0265 article-title: Altered synaptic plasticity in a mouse model of fragile X mental retardation publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 167 start-page: 5970 year: 2001 end-page: 5976 ident: bib0100 article-title: Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA publication-title: Journal of Immunology – volume: 19 start-page: 7793 year: 1999 end-page: 7803 ident: bib0520 article-title: The drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction publication-title: Journal of Neuroscience – volume: 30 start-page: 1962 year: 2008 end-page: 1974 ident: bib0090 article-title: Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines publication-title: Neurobiology of Aging – volume: 7 start-page: 1717 year: 2001 end-page: 1727 ident: bib0155 article-title: The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes publication-title: RNA – volume: 107 start-page: 489 year: 2001 end-page: 499 ident: bib0170 article-title: Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function publication-title: Cell – volume: 276 start-page: 1119 year: 2001 end-page: 1126 ident: bib0550 article-title: Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase publication-title: Journal of Biological Chemistry – volume: 21 start-page: 403 year: 2009 end-page: 408 ident: bib0030 article-title: Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs publication-title: Current Opinion in Cell Biology – volume: 15 start-page: 355 year: 2000 end-page: 367 ident: bib0005 article-title: Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle publication-title: Molecular and Cellular Neuroscience – volume: 16 start-page: 7171 year: 1996 end-page: 7181 ident: bib0515 article-title: Translational machinery in dendrites of hippocampal neurons in culture publication-title: Journal of Neuroscience – volume: 384 start-page: 66 year: 2005 end-page: 71 ident: bib0570 article-title: Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2 publication-title: Neuroscience Letters – volume: 274 start-page: 119 year: 1980 end-page: 123 ident: bib0410 article-title: Fenobam in anxious outpatients publication-title: Current Therapeutic Research – volume: 268 start-page: 8881 year: 1993 end-page: 8887 ident: bib0240 article-title: Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences publication-title: Journal of Biological Chemistry – volume: 120 start-page: 1005 year: 2003 end-page: 1017 ident: bib0125 article-title: The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences publication-title: Neuroscience – volume: 173 start-page: 976 year: 2004 end-page: 985 ident: bib0485 article-title: Nucleolin is a second component of the CD154 mRNA stability complex that regulates mRNA turnover in activated T cells publication-title: Journal of Immunology – volume: 11 start-page: 2460 year: 1991 end-page: 2466 ident: bib0075 article-title: An A publication-title: Molecular and Cellular Biology – volume: 7 start-page: 219 year: 2012 end-page: 245 ident: bib0465 article-title: Molecular mechanisms of fragile X syndrome: a twenty-year perspective publication-title: Annual Review of Pathology – volume: 2 start-page: 261 year: 2005 end-page: 266 ident: bib0390 article-title: Mechanisms of A-beta plaque clearance following passive A-beta immunization publication-title: Neurodegenerative Diseases – volume: 12 start-page: 520 year: 1998 end-page: 531 ident: bib0530 article-title: Characterization of proteins binding the 3′ regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells publication-title: Leukemia – volume: 27 start-page: 787 year: 2006 end-page: 796 ident: bib0555 article-title: Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells publication-title: Neurobiology of Aging – volume: 14 start-page: 1177 year: 2010 end-page: 1197 ident: bib0035 article-title: Novel drug targets based on metallobiology of Alzheimer's disease publication-title: Expert Opinion on Therapeutic Targets – volume: 31 start-page: 3472 year: 2011 end-page: 3484 ident: bib0260 article-title: Prevention of transcriptional silencing by a replicator-binding complex consisting of SWI/SNF, MeCP1, and hnRNP C1/C2 publication-title: Molecular and Cellular Biology – volume: 275 start-page: 31609 year: 2000 end-page: 31615 ident: bib0510 article-title: Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways publication-title: Journal of Biological Chemistry – volume: 26 start-page: 3418 year: 1998 end-page: 3423 ident: bib0435 article-title: hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA publication-title: Nucleic Acids Research – volume: 6 start-page: 376 year: 2005 end-page: 387 ident: bib0025 article-title: From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome publication-title: Nature Reviews Neuroscience – volume: 277 start-page: 45518 year: 2002 end-page: 45528 ident: bib0450 article-title: An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript publication-title: Journal of Biological Chemistry – volume: 178 start-page: 264 year: 1988 end-page: 272 ident: bib0200 article-title: Effects of anti-C23 (nucleolin) antibody on transcription of ribosomal DNA in chironomus salivary gland cells publication-title: Experimental Cell Research – volume: 111 start-page: 165 year: 2003 end-page: 174 ident: bib0270 article-title: Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus publication-title: Brain Research Molecular Brain Research – volume: 71 start-page: 42 year: 1999 end-page: 49 ident: bib0015 article-title: TGF-beta(1), regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization publication-title: Brain Research Molecular Brain Research – volume: 19 start-page: 4311 year: 1999 end-page: 4323 ident: bib0315 article-title: Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA publication-title: Molecular and Cellular Biology – volume: 20 start-page: 2464 year: 2009 end-page: 2472 ident: bib0375 article-title: Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly publication-title: Molecular Biology of the Cell – volume: 20 start-page: 9084 year: 2000 end-page: 9091 ident: bib0220 article-title: Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase publication-title: Molecular and Cellular Biology – volume: 89 start-page: 959 year: 2003 end-page: 966 ident: bib0245 article-title: Posttranscriptional regulation of PAI-1 gene expression publication-title: Thrombosis and Haemostasis – volume: 20 start-page: 5947 year: 2000 end-page: 5959 ident: bib0370 article-title: A U-rich element in the 5′-untranslated region is necessary for the translation of p27 mRNA publication-title: Molecular and Cellular Biology – volume: 55 start-page: 3444 year: 1995 end-page: 3449 ident: bib0010 article-title: The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues publication-title: Cancer Research – volume: 107 start-page: 477 year: 2001 end-page: 487 ident: bib0085 article-title: Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome publication-title: Cell – volume: 298 start-page: 1379 year: 2002 ident: bib0420 article-title: Cerebral hemorrhage after passive anti-Abeta immunotherapy publication-title: Science – volume: 266 start-page: 3172 year: 1991 end-page: 3177 ident: bib0230 article-title: The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs publication-title: Journal of Biological Chemistry – volume: 270 start-page: 28257 year: 1995 end-page: 28267 ident: bib0445 article-title: Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease publication-title: Journal of Biological Chemistry – volume: 27 start-page: 370 year: 2004 end-page: 377 ident: bib0050 article-title: The mGluR theory of fragile X mental retardation publication-title: Trends in Neurosciences – volume: 231 start-page: 1534 year: 1986 end-page: 1539 ident: bib0135 article-title: Heterogeneous nuclear ribonucleoproteins: role in RNA splicing publication-title: Science – volume: 404 start-page: 889 year: 2011 end-page: 895 ident: bib0335 article-title: MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed publication-title: Biochemical and Biophysical Research Communications – volume: 15 start-page: 2219 year: 1995 end-page: 2230 ident: bib0605 article-title: The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation publication-title: Molecular and Cellular Biology – volume: 269 start-page: 24007 year: 1994 end-page: 24013 ident: bib0595 article-title: Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3′-untranslated region publication-title: Journal of Biological Chemistry – volume: 273 start-page: 19025 year: 1998 end-page: 19029 ident: bib0065 article-title: Nucleolin interacts with several ribosomal proteins through its RGG domain publication-title: Journal of Biological Chemistry – volume: 42 start-page: 314 year: 1995 end-page: 322 ident: bib0290 article-title: A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1 publication-title: Journal of Neuroscience Research – volume: 3 start-page: 10 year: 2008 ident: bib0405 article-title: MicroRNAs can regulate human APP levels publication-title: Molecular Neurodegeneration – volume: 329 start-page: 489 year: 1987 end-page: 490 ident: bib0280 article-title: At the heart of the nucleolus publication-title: Nature – volume: 7 start-page: 200 year: 2010 end-page: 206 ident: bib0345 article-title: Fragile X syndrome and Alzheimer's disease: another story about APP and beta-amyloid publication-title: Current Alzheimer Research – volume: 23 start-page: 280 year: 2003 end-page: 288 ident: bib0255 article-title: The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2 publication-title: Molecular and Cellular Biology – volume: 34 start-page: 3082 year: 2006 end-page: 3094 ident: bib0560 article-title: Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation publication-title: Nucleic Acids Research – volume: 37 start-page: 417 year: 2003 end-page: 431 ident: bib0385 article-title: RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice publication-title: Neuron – volume: 10 start-page: 1891 year: 1991 end-page: 1902 ident: bib0160 article-title: Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA publication-title: EMBO Journal – volume: 6 start-page: 916 year: 2000 end-page: 919 ident: bib0045 article-title: Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease publication-title: Nature Medicine – volume: 6 start-page: e26549 year: 2011 ident: bib0535 article-title: Reversal of fragile X phenotypes by manipulation of APP/Abeta levels in Fmr1 mice publication-title: PLoS ONE – volume: 274 start-page: 144 year: 1980 end-page: 151 ident: bib0225 article-title: Phase II double blind controlled study of a new anxiolytic, fenobam (McN-3377) vs placebo publication-title: Current Therapeutic Research – volume: 22 start-page: 6331 year: 2002 end-page: 6335 ident: bib0300 article-title: Reversible memory loss in a mouse transgenic model of Alzheimer's disease publication-title: Journal of Neuroscience – volume: 75 start-page: 301 year: 2004 end-page: 306 ident: bib0095 article-title: Anti-abeta: the good, the bad, and the unforeseen publication-title: Journal of Neuroscience Research – volume: 5 start-page: e52 year: 2007 ident: bib0540 article-title: FMRP mediates mGluR5-dependent translation of amyloid precursor protein publication-title: PLoS Biology – volume: 269 start-page: 24000 year: 1994 end-page: 24006 ident: bib0590 article-title: Multiple proteins interact at a unique cis-element in the 3′-untranslated region of amyloid precursor protein mRNA publication-title: Journal of Biological Chemistry – volume: 25 start-page: 544 year: 2006 end-page: 553 ident: bib0150 article-title: Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe–S cluster publication-title: EMBO Journal – volume: 18 start-page: 5430 year: 2011 end-page: 5447 ident: bib0395 article-title: Interacting with gamma-secretase for treating Alzheimer's disease: from inhibition to modulation publication-title: Current Medicinal Chemistry – volume: 31 start-page: 95-101 year: 1982 ident: bib0320 article-title: Fenobam: another anxiolytic? publication-title: Current Therapeutic Research – volume: 24 start-page: 3624 year: 2005 end-page: 3634 ident: bib0490 article-title: Homo- and heterodimerization of APP family members promotes intercellular adhesion publication-title: EMBO Journal – volume: 82 start-page: 4245 year: 1985 end-page: 4249 ident: bib0355 article-title: Amyloid plaque core protein in Alzheimer disease and Down syndrome publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 282 start-page: 37389 year: 2007 end-page: 37401 ident: bib0380 article-title: CPEB interacts with an ovary-specific eIF4E and 4E-T in early publication-title: Journal of Biological Chemistry – volume: 3 start-page: 499 year: 2010 end-page: 503 ident: bib0460 article-title: Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins publication-title: Communicative & Integrative Biology – volume: 273 start-page: 28057 year: 1998 end-page: 28064 ident: bib0080 article-title: Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3 publication-title: Journal of Biological Chemistry – volume: 160 start-page: 143 year: 1995 end-page: 148 ident: bib0525 article-title: Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation publication-title: Gene – volume: 24 start-page: 7272 year: 2004 end-page: 7276 ident: bib0495 article-title: Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells publication-title: Journal of Neuroscience – volume: 52 start-page: 997 year: 2006 end-page: 1009 ident: bib0040 article-title: Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies publication-title: Neuron – volume: 11 start-page: 3099 year: 1992 end-page: 3103 ident: bib0175 article-title: Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation publication-title: EMBO Journal – volume: 17 start-page: 1476 year: 1998 end-page: 1486 ident: bib0235 article-title: Nucleolin functions in the first step of ribosomal RNA processing publication-title: EMBO Journal – volume: 17 start-page: 6625 year: 1989 end-page: 6636 ident: bib0055 article-title: Protein kinase NII and the regulation of rDNA transcription in mammalian cells publication-title: Nucleic Acids Research – volume: 11 start-page: 3007 year: 2002 end-page: 3017 ident: bib0360 article-title: Trapping of messenger RNA by fragile X mental retardation protein into cytoplasmic granules induces translation repression publication-title: Human Molecular Genetics – volume: 270 start-page: 17292 year: 1995 end-page: 17298 ident: bib0585 article-title: Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3′-untranslated region of amyloid protein precursor mRNA publication-title: Journal of Biological Chemistry – volume: 285 start-page: 31217 year: 2010 end-page: 31232 ident: bib0130 article-title: Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1 publication-title: Journal of Biological Chemistry – volume: 81 start-page: 7471 year: 1984 end-page: 7475 ident: bib0140 article-title: Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 175 start-page: 525 year: 1988 end-page: 530 ident: bib0205 article-title: A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1 publication-title: European Journal of Biochemistry – volume: 25 start-page: 629 year: 2005 end-page: 636 ident: bib0425 article-title: Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta publication-title: Journal of Neuroscience – volume: 270 start-page: 4983 year: 1995 end-page: 4986 ident: bib0295 article-title: Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2 publication-title: Journal of Biological Chemistry – volume: 270 start-page: 28297 year: 1995 end-page: 28303 ident: bib0070 article-title: Sequence-specific RNA recognition by the publication-title: Journal of Biological Chemistry – volume: 10 start-page: 1038 year: 2000 end-page: 1044 ident: bib0275 article-title: Dendritic spine structural anomalies in fragile-X mental retardation syndrome publication-title: Cerebral Cortex – volume: 102 start-page: 15012 year: 2005 end-page: 15017 ident: bib0340 article-title: Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 10 start-page: 329 year: 2001 end-page: 338 ident: bib0305 article-title: Evidence that fragile X mental retardation protein is a negative regulator of translation publication-title: Human Molecular Genetics – volume: 592 start-page: 353 year: 1992 end-page: 357 ident: bib0480 article-title: Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons publication-title: Brain Research – volume: 7 start-page: 1725 year: 1993 end-page: 1736 ident: bib0440 article-title: Masking mRNA from translation in somatic cells publication-title: Genes & Development – volume: 56 start-page: 379 year: 1989 end-page: 390 ident: bib0060 article-title: Major nucleolar proteins shuttle between nucleus and cytoplasm publication-title: Cell – volume: 14 start-page: 1236 year: 2000 end-page: 1248 ident: bib0120 article-title: Nucleolin and YB1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation publication-title: Genes & Development – volume: 14 start-page: 7984 year: 1994 end-page: 7995 ident: bib0310 article-title: AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A) publication-title: Molecular and Cellular Biology – volume: 305 start-page: 434 year: 2003 end-page: 441 ident: bib0195 article-title: The fragile X mental retardation protein interacts with U-rich RNAs in a yeast three-hybrid system publication-title: Biochemical and Biophysical Research Communications – volume: 8 start-page: 251 year: 2001 end-page: 262 ident: bib0505 article-title: DExD/H box RNA helicases: from generic motors to specific dissociation functions publication-title: Molecular Cell – volume: 10 start-page: 6397 year: 1990 end-page: 6407 ident: bib0565 article-title: A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal publication-title: Molecular and Cellular Biology – volume: 1731 start-page: 32 year: 2005 end-page: 40 ident: bib0215 article-title: Role of nucleolin in posttranscriptional control of MMP-9 expression publication-title: Biochimica et Biophysica Acta – volume: 17 start-page: 3028 year: 1997 end-page: 3036 ident: bib0365 article-title: Human La protein: a stabilizer of histone mRNA publication-title: Molecular and Cellular Biology – volume: 106 start-page: 579 year: 2000 end-page: 587 ident: bib0500 article-title: Thrombin activates a Y box-binding protein (DNA-binding protein B) in endothelial cells publication-title: Journal of Clinical Investigation – volume: 276 start-page: 3341 year: 2001 end-page: 3347 ident: bib0250 article-title: Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA publication-title: Journal of Biological Chemistry – volume: 46 start-page: 659 year: 1986 end-page: 667 ident: bib0475 article-title: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation publication-title: Cell – volume: 73 start-page: 497 year: 1995 end-page: 502 ident: bib0185 article-title: The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells publication-title: Laboratory Investigation – volume: 85 start-page: 7322 year: 1988 end-page: 7326 ident: bib0190 article-title: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 8 start-page: 9 year: 2007 end-page: 22 ident: bib0210 article-title: P bodies: at the crossroads of post-transcriptional pathways publication-title: Nature Reviews Molecular Cell Biology – volume: 272 start-page: 10870 year: 1997 end-page: 10876 ident: bib0580 article-title: A translation regulatory particle containing the publication-title: Journal of Biological Chemistry – volume: 288 start-page: 29 year: 1991 end-page: 38 ident: bib0180 article-title: Distribution and activity of alternatively spliced Alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes publication-title: Archives of Biochemistry and Biophysics – volume: 19 start-page: 5296 year: 2008 end-page: 5308 ident: bib0285 article-title: eEF1A is a novel component of the mammalian nuclear protein export machinery publication-title: Molecular Biology of the Cell – volume: 29 start-page: 2276 year: 2001 end-page: 2283 ident: bib0330 article-title: The fragile X mental retardation protein inhibits translation via interacting with mRNA publication-title: Nucleic Acids Research – volume: 274 start-page: 6421 year: 1999 end-page: 6431 ident: bib0455 article-title: Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences publication-title: Journal of Biological Chemistry – volume: 17 start-page: 732 year: 2010 end-page: 739 ident: bib0325 article-title: hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies publication-title: Nature Structural & Molecular Biology – volume: 19 start-page: 903 year: 2005 end-page: 918 ident: bib0165 article-title: Kissing complex RNAs mediate interaction between the fragile-X mental retardation protein KH2 domain and brain polyribosomes publication-title: Genes & Development – volume: 90 start-page: 193 year: 2001 end-page: 201 ident: bib0545 article-title: Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay publication-title: Brain Research Molecular Brain Research – volume: 4 start-page: e210 year: 2006 ident: bib0145 article-title: Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 publication-title: PLoS Biology – volume: 14 start-page: 6068 year: 1994 end-page: 6074 ident: bib0575 article-title: Purification and characterization of nucleolin and its identification as a transcription repressor publication-title: Molecular and Cellular Biology – volume: 25 start-page: 635 year: 2007 end-page: 646 ident: bib0400 article-title: P bodies and the control of mRNA translation and degradation publication-title: Molecular Cell – volume: 80 start-page: 2629 year: 1999 end-page: 2638 ident: bib0020 article-title: Interaction of YB1 with human immunodeficiency virus type 1 tat and TAR RNA modulates viral promoter activity publication-title: Journal of General Virology – volume: 74 start-page: 52 year: 2000 end-page: 59 ident: bib0430 article-title: Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3′-untranslated region publication-title: Journal of Neurochemistry – volume: 279 start-page: 10855 year: 2004 end-page: 10863 ident: bib0470 article-title: Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization publication-title: Journal of Biological Chemistry – volume: 112 start-page: 317 year: 2003 end-page: 327 ident: bib0600 article-title: The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses publication-title: Cell – volume: 83 start-page: 1670 year: 1986 end-page: 1674 ident: bib0105 article-title: Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 415 start-page: 462 year: 2002 ident: bib0115 article-title: Nerve inflammation halts trial for Alzheimer's drug publication-title: Nature – volume: 19 start-page: 7925 year: 1999 end-page: 7932 ident: bib0110 article-title: Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex publication-title: Molecular and Cellular Biology – volume: 19 start-page: 7925 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0110 article-title: Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.19.12.7925 – volume: 14 start-page: 7984 year: 1994 ident: 10.1016/j.arr.2012.03.005_bib0310 article-title: AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A) publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.14.12.7984 – volume: 270 start-page: 28297 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0070 article-title: Sequence-specific RNA recognition by the Xenopus Y-box proteins. An essential role for the cold shock domain publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.270.47.28297 – volume: 592 start-page: 353 year: 1992 ident: 10.1016/j.arr.2012.03.005_bib0480 article-title: Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons publication-title: Brain Research doi: 10.1016/0006-8993(92)91697-D – volume: 276 start-page: 3341 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0250 article-title: Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the type-1 plasminogen activator inhibitor mRNA publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M006538200 – volume: 23 start-page: 280 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0255 article-title: The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.23.1.280-288.2003 – volume: 15 start-page: 355 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0005 article-title: Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle publication-title: Molecular and Cellular Neuroscience doi: 10.1006/mcne.2000.0834 – volume: 102 start-page: 15012 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0340 article-title: Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0507596102 – volume: 167 start-page: 5970 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0100 article-title: Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA publication-title: Journal of Immunology doi: 10.4049/jimmunol.167.10.5970 – volume: 10 start-page: 1038 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0275 article-title: Dendritic spine structural anomalies in fragile-X mental retardation syndrome publication-title: Cerebral Cortex doi: 10.1093/cercor/10.10.1038 – volume: 6 start-page: 376 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0025 article-title: From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome publication-title: Nature Reviews Neuroscience doi: 10.1038/nrn1667 – volume: 106 start-page: 579 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0500 article-title: Thrombin activates a Y box-binding protein (DNA-binding protein B) in endothelial cells publication-title: Journal of Clinical Investigation doi: 10.1172/JCI9075 – volume: 24 start-page: 3624 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0490 article-title: Homo- and heterodimerization of APP family members promotes intercellular adhesion publication-title: EMBO Journal doi: 10.1038/sj.emboj.7600824 – volume: 17 start-page: 732 year: 2010 ident: 10.1016/j.arr.2012.03.005_bib0325 article-title: hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies publication-title: Nature Structural & Molecular Biology doi: 10.1038/nsmb.1815 – volume: 82 start-page: 4245 year: 1985 ident: 10.1016/j.arr.2012.03.005_bib0355 article-title: Amyloid plaque core protein in Alzheimer disease and Down syndrome publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.82.12.4245 – volume: 17 start-page: 6625 year: 1989 ident: 10.1016/j.arr.2012.03.005_bib0055 article-title: Protein kinase NII and the regulation of rDNA transcription in mammalian cells publication-title: Nucleic Acids Research doi: 10.1093/nar/17.16.6625 – volume: 71 start-page: 42 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0015 article-title: TGF-beta(1), regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization publication-title: Brain Research Molecular Brain Research doi: 10.1016/S0169-328X(99)00158-8 – volume: 298 start-page: 1379 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0420 article-title: Cerebral hemorrhage after passive anti-Abeta immunotherapy publication-title: Science doi: 10.1126/science.1078259 – volume: 276 start-page: 1119 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0550 article-title: Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M009435200 – volume: 2 start-page: 129 year: 1982 ident: 10.1016/j.arr.2012.03.005_bib0415 article-title: Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study publication-title: Journal of Clinical Psychopharmacology doi: 10.1097/00004714-198204000-00010 – volume: 274 start-page: 144 year: 1980 ident: 10.1016/j.arr.2012.03.005_bib0225 article-title: Phase II double blind controlled study of a new anxiolytic, fenobam (McN-3377) vs placebo publication-title: Current Therapeutic Research – volume: 2 start-page: 261 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0390 article-title: Mechanisms of A-beta plaque clearance following passive A-beta immunization publication-title: Neurodegenerative Diseases doi: 10.1159/000090366 – volume: 15 start-page: 2219 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0605 article-title: The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.15.4.2219 – volume: 272 start-page: 10870 year: 1997 ident: 10.1016/j.arr.2012.03.005_bib0580 article-title: A translation regulatory particle containing the Xenopus oocyte Y box protein mRNP3+4 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.272.16.10870 – volume: 83 start-page: 1670 year: 1986 ident: 10.1016/j.arr.2012.03.005_bib0105 article-title: Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.83.6.1670 – volume: 270 start-page: 17292 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0585 article-title: Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3′-untranslated region of amyloid protein precursor mRNA publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.270.29.17292 – volume: 273 start-page: 19025 year: 1998 ident: 10.1016/j.arr.2012.03.005_bib0065 article-title: Nucleolin interacts with several ribosomal proteins through its RGG domain publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.30.19025 – volume: 11 start-page: 3007 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0360 article-title: Trapping of messenger RNA by fragile X mental retardation protein into cytoplasmic granules induces translation repression publication-title: Human Molecular Genetics doi: 10.1093/hmg/11.24.3007 – volume: 16 start-page: 7171 year: 1996 ident: 10.1016/j.arr.2012.03.005_bib0515 article-title: Translational machinery in dendrites of hippocampal neurons in culture publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.16-22-07171.1996 – volume: 20 start-page: 9084 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0220 article-title: Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.20.23.9084-9091.2000 – volume: 19 start-page: 7793 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0520 article-title: The drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.19-18-07793.1999 – volume: 285 start-page: 31217 year: 2010 ident: 10.1016/j.arr.2012.03.005_bib0130 article-title: Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M110.149161 – volume: 81 start-page: 7471 year: 1984 ident: 10.1016/j.arr.2012.03.005_bib0140 article-title: Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.81.23.7471 – volume: 89 start-page: 959 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0245 article-title: Posttranscriptional regulation of PAI-1 gene expression publication-title: Thrombosis and Haemostasis doi: 10.1055/s-0037-1613396 – volume: 270 start-page: 4983 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0295 article-title: Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.270.10.4983 – volume: 7 start-page: 1725 year: 1993 ident: 10.1016/j.arr.2012.03.005_bib0440 article-title: Masking mRNA from translation in somatic cells publication-title: Genes & Development doi: 10.1101/gad.7.9.1725 – volume: 268 start-page: 8881 year: 1993 ident: 10.1016/j.arr.2012.03.005_bib0240 article-title: Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)52955-0 – volume: 27 start-page: 370 year: 2004 ident: 10.1016/j.arr.2012.03.005_bib0050 article-title: The mGluR theory of fragile X mental retardation publication-title: Trends in Neurosciences doi: 10.1016/j.tins.2004.04.009 – volume: 12 start-page: 520 year: 1998 ident: 10.1016/j.arr.2012.03.005_bib0530 article-title: Characterization of proteins binding the 3′ regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells publication-title: Leukemia doi: 10.1038/sj.leu.2400975 – volume: 273 start-page: 28057 year: 1998 ident: 10.1016/j.arr.2012.03.005_bib0080 article-title: Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.43.28057 – volume: 7 start-page: 200 year: 2010 ident: 10.1016/j.arr.2012.03.005_bib0345 article-title: Fragile X syndrome and Alzheimer's disease: another story about APP and beta-amyloid publication-title: Current Alzheimer Research doi: 10.2174/156720510791050957 – volume: 25 start-page: 629 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0425 article-title: Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.4337-04.2005 – volume: 52 start-page: 997 year: 2006 ident: 10.1016/j.arr.2012.03.005_bib0040 article-title: Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies publication-title: Neuron doi: 10.1016/j.neuron.2006.10.028 – volume: 27 start-page: 787 year: 2006 ident: 10.1016/j.arr.2012.03.005_bib0555 article-title: Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells publication-title: Neurobiology of Aging doi: 10.1016/j.neurobiolaging.2006.03.003 – volume: 6 start-page: 916 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0045 article-title: Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease publication-title: Nature Medicine doi: 10.1038/78682 – volume: 85 start-page: 7322 year: 1988 ident: 10.1016/j.arr.2012.03.005_bib0190 article-title: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.85.19.7322 – volume: 7 start-page: 219 year: 2012 ident: 10.1016/j.arr.2012.03.005_bib0465 article-title: Molecular mechanisms of fragile X syndrome: a twenty-year perspective publication-title: Annual Review of Pathology doi: 10.1146/annurev-pathol-011811-132457 – volume: 17 start-page: 1476 year: 1998 ident: 10.1016/j.arr.2012.03.005_bib0235 article-title: Nucleolin functions in the first step of ribosomal RNA processing publication-title: EMBO Journal doi: 10.1093/emboj/17.5.1476 – volume: 29 start-page: 2276 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0330 article-title: The fragile X mental retardation protein inhibits translation via interacting with mRNA publication-title: Nucleic Acids Research doi: 10.1093/nar/29.11.2276 – volume: 25 start-page: 544 year: 2006 ident: 10.1016/j.arr.2012.03.005_bib0150 article-title: Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe–S cluster publication-title: EMBO Journal doi: 10.1038/sj.emboj.7600954 – volume: 20 start-page: 5947 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0370 article-title: A U-rich element in the 5′-untranslated region is necessary for the translation of p27 mRNA publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.20.16.5947-5959.2000 – volume: 10 start-page: 6397 year: 1990 ident: 10.1016/j.arr.2012.03.005_bib0565 article-title: A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.10.12.6397 – volume: 277 start-page: 45518 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0450 article-title: An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M207435200 – volume: 19 start-page: 5296 year: 2008 ident: 10.1016/j.arr.2012.03.005_bib0285 article-title: eEF1A is a novel component of the mammalian nuclear protein export machinery publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.E08-06-0562 – volume: 34 start-page: 3082 year: 2006 ident: 10.1016/j.arr.2012.03.005_bib0560 article-title: Xp54 and related (DDX6-like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation publication-title: Nucleic Acids Research doi: 10.1093/nar/gkl409 – volume: 11 start-page: 2460 year: 1991 ident: 10.1016/j.arr.2012.03.005_bib0075 article-title: An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.11.5.2460 – volume: 21 start-page: 403 year: 2009 ident: 10.1016/j.arr.2012.03.005_bib0030 article-title: Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs publication-title: Current Opinion in Cell Biology doi: 10.1016/j.ceb.2009.03.005 – volume: 4 start-page: e210 year: 2006 ident: 10.1016/j.arr.2012.03.005_bib0145 article-title: Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 publication-title: PLoS Biology doi: 10.1371/journal.pbio.0040210 – volume: 231 start-page: 1534 year: 1986 ident: 10.1016/j.arr.2012.03.005_bib0135 article-title: Heterogeneous nuclear ribonucleoproteins: role in RNA splicing publication-title: Science doi: 10.1126/science.3952495 – volume: 10 start-page: 329 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0305 article-title: Evidence that fragile X mental retardation protein is a negative regulator of translation publication-title: Human Molecular Genetics doi: 10.1093/hmg/10.4.329 – volume: 73 start-page: 497 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0185 article-title: The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells publication-title: Laboratory Investigation – volume: 1731 start-page: 32 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0215 article-title: Role of nucleolin in posttranscriptional control of MMP-9 expression publication-title: Biochimica et Biophysica Acta doi: 10.1016/j.bbaexp.2005.08.005 – volume: 90 start-page: 193 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0545 article-title: Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay publication-title: Brain Research Molecular Brain Research doi: 10.1016/S0169-328X(01)00112-7 – volume: 269 start-page: 24000 year: 1994 ident: 10.1016/j.arr.2012.03.005_bib0590 article-title: Multiple proteins interact at a unique cis-element in the 3′-untranslated region of amyloid precursor protein mRNA publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)51038-9 – volume: 175 start-page: 525 year: 1988 ident: 10.1016/j.arr.2012.03.005_bib0205 article-title: A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1 publication-title: European Journal of Biochemistry doi: 10.1111/j.1432-1033.1988.tb14224.x – volume: 14 start-page: 1177 year: 2010 ident: 10.1016/j.arr.2012.03.005_bib0035 article-title: Novel drug targets based on metallobiology of Alzheimer's disease publication-title: Expert Opinion on Therapeutic Targets doi: 10.1517/14728222.2010.525352 – volume: 282 start-page: 37389 year: 2007 ident: 10.1016/j.arr.2012.03.005_bib0380 article-title: CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M704629200 – volume: 329 start-page: 489 year: 1987 ident: 10.1016/j.arr.2012.03.005_bib0280 article-title: At the heart of the nucleolus publication-title: Nature doi: 10.1038/329489a0 – volume: 75 start-page: 301 year: 2004 ident: 10.1016/j.arr.2012.03.005_bib0095 article-title: Anti-abeta: the good, the bad, and the unforeseen publication-title: Journal of Neuroscience Research doi: 10.1002/jnr.10876 – volume: 305 start-page: 434 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0195 article-title: The fragile X mental retardation protein interacts with U-rich RNAs in a yeast three-hybrid system publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/S0006-291X(03)00766-6 – volume: 173 start-page: 976 year: 2004 ident: 10.1016/j.arr.2012.03.005_bib0485 article-title: Nucleolin is a second component of the CD154 mRNA stability complex that regulates mRNA turnover in activated T cells publication-title: Journal of Immunology doi: 10.4049/jimmunol.173.2.976 – volume: 24 start-page: 7272 year: 2004 ident: 10.1016/j.arr.2012.03.005_bib0495 article-title: Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.2306-04.2004 – volume: 8 start-page: 251 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0505 article-title: DExD/H box RNA helicases: from generic motors to specific dissociation functions publication-title: Molecular Cell doi: 10.1016/S1097-2765(01)00329-X – volume: 107 start-page: 477 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0085 article-title: Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome publication-title: Cell doi: 10.1016/S0092-8674(01)00568-2 – volume: 99 start-page: 7746 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0265 article-title: Altered synaptic plasticity in a mouse model of fragile X mental retardation publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.122205699 – volume: 31 start-page: 95-101 year: 1982 ident: 10.1016/j.arr.2012.03.005_bib0320 article-title: Fenobam: another anxiolytic? publication-title: Current Therapeutic Research – volume: 107 start-page: 489 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0170 article-title: Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function publication-title: Cell doi: 10.1016/S0092-8674(01)00566-9 – volume: 11 start-page: 3099 year: 1992 ident: 10.1016/j.arr.2012.03.005_bib0175 article-title: Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation publication-title: EMBO Journal doi: 10.1002/j.1460-2075.1992.tb05382.x – volume: 25 start-page: 635 year: 2007 ident: 10.1016/j.arr.2012.03.005_bib0400 article-title: P bodies and the control of mRNA translation and degradation publication-title: Molecular Cell doi: 10.1016/j.molcel.2007.02.011 – volume: 112 start-page: 317 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0600 article-title: The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses publication-title: Cell doi: 10.1016/S0092-8674(03)00079-5 – volume: 7 start-page: 1717 year: 2001 ident: 10.1016/j.arr.2012.03.005_bib0155 article-title: The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes publication-title: RNA doi: 10.1017/S135583820101994X – volume: 120 start-page: 1005 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0125 article-title: The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences publication-title: Neuroscience doi: 10.1016/S0306-4522(03)00406-8 – volume: 17 start-page: 3028 year: 1997 ident: 10.1016/j.arr.2012.03.005_bib0365 article-title: Human La protein: a stabilizer of histone mRNA publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.17.6.3028 – volume: 5 start-page: e52 year: 2007 ident: 10.1016/j.arr.2012.03.005_bib0540 article-title: FMRP mediates mGluR5-dependent translation of amyloid precursor protein publication-title: PLoS Biology doi: 10.1371/journal.pbio.0050052 – volume: 42 start-page: 314 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0290 article-title: A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1 publication-title: Journal of Neuroscience Research doi: 10.1002/jnr.490420305 – volume: 274 start-page: 119 year: 1980 ident: 10.1016/j.arr.2012.03.005_bib0410 article-title: Fenobam in anxious outpatients publication-title: Current Therapeutic Research – volume: 74 start-page: 52 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0430 article-title: Growth factor-mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29-nucleotide sequence in the 3′-untranslated region publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.2000.0740052.x – volume: 10 start-page: 1891 year: 1991 ident: 10.1016/j.arr.2012.03.005_bib0160 article-title: Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA publication-title: EMBO Journal doi: 10.1002/j.1460-2075.1991.tb07715.x – volume: 178 start-page: 264 year: 1988 ident: 10.1016/j.arr.2012.03.005_bib0200 article-title: Effects of anti-C23 (nucleolin) antibody on transcription of ribosomal DNA in chironomus salivary gland cells publication-title: Experimental Cell Research doi: 10.1016/0014-4827(88)90397-7 – volume: 160 start-page: 143 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0525 article-title: Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation publication-title: Gene doi: 10.1016/0378-1119(95)00207-M – volume: 55 start-page: 3444 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0010 article-title: The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues publication-title: Cancer Research – volume: 404 start-page: 889 year: 2011 ident: 10.1016/j.arr.2012.03.005_bib0335 article-title: MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2010.12.053 – volume: 279 start-page: 10855 year: 2004 ident: 10.1016/j.arr.2012.03.005_bib0470 article-title: Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M309111200 – volume: 18 start-page: 5430 year: 2011 ident: 10.1016/j.arr.2012.03.005_bib0395 article-title: Interacting with gamma-secretase for treating Alzheimer's disease: from inhibition to modulation publication-title: Current Medicinal Chemistry doi: 10.2174/092986711798194351 – volume: 266 start-page: 3172 year: 1991 ident: 10.1016/j.arr.2012.03.005_bib0230 article-title: The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)49970-X – volume: 384 start-page: 66 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0570 article-title: Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2 publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2005.04.040 – volume: 30 start-page: 1962 year: 2008 ident: 10.1016/j.arr.2012.03.005_bib0090 article-title: Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines publication-title: Neurobiology of Aging doi: 10.1016/j.neurobiolaging.2008.02.011 – volume: 274 start-page: 6421 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0455 article-title: Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.274.10.6421 – volume: 275 start-page: 31609 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0510 article-title: Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M002354200 – volume: 3 start-page: 10 year: 2008 ident: 10.1016/j.arr.2012.03.005_bib0405 article-title: MicroRNAs can regulate human APP levels publication-title: Molecular Neurodegeneration doi: 10.1186/1750-1326-3-10 – volume: 46 start-page: 659 year: 1986 ident: 10.1016/j.arr.2012.03.005_bib0475 article-title: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation publication-title: Cell doi: 10.1016/0092-8674(86)90341-7 – volume: 19 start-page: 903 year: 2005 ident: 10.1016/j.arr.2012.03.005_bib0165 article-title: Kissing complex RNAs mediate interaction between the fragile-X mental retardation protein KH2 domain and brain polyribosomes publication-title: Genes & Development doi: 10.1101/gad.1276805 – volume: 14 start-page: 6068 year: 1994 ident: 10.1016/j.arr.2012.03.005_bib0575 article-title: Purification and characterization of nucleolin and its identification as a transcription repressor publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.14.9.6068 – volume: 56 start-page: 379 year: 1989 ident: 10.1016/j.arr.2012.03.005_bib0060 article-title: Major nucleolar proteins shuttle between nucleus and cytoplasm publication-title: Cell doi: 10.1016/0092-8674(89)90241-9 – volume: 31 start-page: 3472 year: 2011 ident: 10.1016/j.arr.2012.03.005_bib0260 article-title: Prevention of transcriptional silencing by a replicator-binding complex consisting of SWI/SNF, MeCP1, and hnRNP C1/C2 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.05587-11 – volume: 14 start-page: 1236 year: 2000 ident: 10.1016/j.arr.2012.03.005_bib0120 article-title: Nucleolin and YB1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation publication-title: Genes & Development doi: 10.1101/gad.14.10.1236 – volume: 3 start-page: 499 year: 2010 ident: 10.1016/j.arr.2012.03.005_bib0460 article-title: Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins publication-title: Communicative & Integrative Biology doi: 10.4161/cib.3.6.13172 – volume: 270 start-page: 28257 year: 1995 ident: 10.1016/j.arr.2012.03.005_bib0445 article-title: Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.270.47.28257 – volume: 19 start-page: 4311 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0315 article-title: Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.19.6.4311 – volume: 288 start-page: 29 year: 1991 ident: 10.1016/j.arr.2012.03.005_bib0180 article-title: Distribution and activity of alternatively spliced Alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes publication-title: Archives of Biochemistry and Biophysics doi: 10.1016/0003-9861(91)90161-B – volume: 246 start-page: 664 year: 1989 ident: 10.1016/j.arr.2012.03.005_bib0350 article-title: Identification of an AUUUA-specific messenger RNA binding protein publication-title: Science doi: 10.1126/science.2814487 – volume: 6 start-page: e26549 year: 2011 ident: 10.1016/j.arr.2012.03.005_bib0535 article-title: Reversal of fragile X phenotypes by manipulation of APP/Abeta levels in Fmr1 mice publication-title: PLoS ONE doi: 10.1371/journal.pone.0026549 – volume: 111 start-page: 165 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0270 article-title: Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus publication-title: Brain Research Molecular Brain Research doi: 10.1016/S0169-328X(03)00027-5 – volume: 22 start-page: 6331 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0300 article-title: Reversible memory loss in a mouse transgenic model of Alzheimer's disease publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.22-15-06331.2002 – volume: 415 start-page: 462 year: 2002 ident: 10.1016/j.arr.2012.03.005_bib0115 article-title: Nerve inflammation halts trial for Alzheimer's drug publication-title: Nature doi: 10.1038/415462a – volume: 26 start-page: 3418 year: 1998 ident: 10.1016/j.arr.2012.03.005_bib0435 article-title: hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA publication-title: Nucleic Acids Research doi: 10.1093/nar/26.14.3418 – volume: 269 start-page: 24007 year: 1994 ident: 10.1016/j.arr.2012.03.005_bib0595 article-title: Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3′-untranslated region publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)51039-0 – volume: 20 start-page: 2464 year: 2009 ident: 10.1016/j.arr.2012.03.005_bib0375 article-title: Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.E09-01-0035 – volume: 80 start-page: 2629 year: 1999 ident: 10.1016/j.arr.2012.03.005_bib0020 article-title: Interaction of YB1 with human immunodeficiency virus type 1 tat and TAR RNA modulates viral promoter activity publication-title: Journal of General Virology doi: 10.1099/0022-1317-80-10-2629 – volume: 8 start-page: 9 year: 2007 ident: 10.1016/j.arr.2012.03.005_bib0210 article-title: P bodies: at the crossroads of post-transcriptional pathways publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm2080 – volume: 37 start-page: 417 year: 2003 ident: 10.1016/j.arr.2012.03.005_bib0385 article-title: RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice publication-title: Neuron doi: 10.1016/S0896-6273(03)00034-5 |
| SSID | ssj0016962 |
| Score | 2.1037304 |
| SecondaryResourceType | review_article |
| Snippet | ► Multiple RBPs interact with distinct cis-elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis-elements and mediate message stability. ► IRP1... Highlights ► Multiple RBPs interact with distinct cis -elements in APP mRNA. ► hnRNP C and nucleolin bind to 3′-UTR cis -elements and mediate message... Amyloid β-protein precursor (AβPP) is cleaved by β- and γ-secretases to liberate amyloid beta (Aβ), the predominant protein found in the senile plaques... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 450 |
| SubjectTerms | Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - genetics Amyloid beta-Protein Precursor - biosynthesis Amyloid beta-Protein Precursor - genetics Animals AβPP FMRP hnRNP C Humans Internal Medicine Neurology Nucleolin Post-transcriptional gene regulation Protein Processing, Post-Translational - genetics RNA Processing, Post-Transcriptional - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics |
| Title | The regulation of AβPP expression by RNA-binding proteins |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1568163712000499 https://www.clinicalkey.es/playcontent/1-s2.0-S1568163712000499 https://www.ncbi.nlm.nih.gov/pubmed/22504584 https://www.proquest.com/docview/1074780183 https://pubmed.ncbi.nlm.nih.gov/PMC3402637 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fT9swELe28rKXaYz96cYmTxp7GEqVOE7a7C1UTAgNFBWQeLPsxIEimqK2PLCPtQ-yz7S72E5DYWjjJaoSu0l8v5zP57vfEfKZSx7mMBN5hWaJx2UZeRKsBi9SisF8U7KijwnOB4fx3gnfP41OXa12m12yUL385715JY-RKpwDuWKW7H9ItvlTOAG_Qb5wBAnD8Z9lPDLF5K3dl24Nd7d2WJYhh7EJca3Qwhwdpt7O2GSwZEjNMLZeOkdAe6bxkqX-ObcZLY29jfVnJjaqeihncnu_t3RlX9raHnXA7fZRr-1IwIiMxDkSrO6LYUEZGw6WnjbnBn3mJbFhFW0UZtACBm9pP244ZO1Eyg3V9x0dbdwFFz05Qz5W9MUiyWzUbgvDfDWphcaQYi0yVeRWiLGzg2EIq1944KdkjcEqwe-QtXQ4-pE120hxUleUbd7MbWvXAX4r90daaHuzv9kod9cgq6G0Ldvk-AV5bhcVNDUIWSdPdPWSbKSVXEwnN_QLrcN86_2TDfINQEOXoKHTkqa_f2UZXQKGqhvaAgx1gHlFTr7vHg_3PFtAw8t5HCw8WTJQsVKrEPS0BEsuzPOCSaZ8XSS8VGoAFkzhx-WAaZ1EUR8OuVQSbepCq0H4mnSqaaXfEspymbBYFpwnAx5IP1GhTHyudMD8Qkb9LvHdkIncsstjkZNL4cIIL5DFXOCACz8UMOBd8rXpcmWoVR5qzJwchMsZhllOAKge6tS_r5Oe2294LgIxh8biCBGCAAmYcQJ0yScnawH6FjfRZKWn19Cjrjjhw0zYJW-M7Jund_iB-95CRdMAudxvX6nG5zWnu0Xyu0f3fE-eLT_qTdJZzK71B7CXF-qj_Sr-AKqWvNU |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Regulation+of+A%CE%B2PP+Expression+by+RNA-Binding+Proteins&rft.jtitle=Ageing+research+reviews&rft.au=Westmark%2C+Cara+J.&rft.au=Malter%2C+James+S.&rft.date=2012-09-01&rft.issn=1568-1637&rft.eissn=1872-9649&rft.volume=11&rft.issue=4&rft.spage=450&rft.epage=459&rft_id=info:doi/10.1016%2Fj.arr.2012.03.005&rft_id=info%3Apmid%2F22504584&rft.externalDocID=PMC3402637 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F15681637%2FS1568163712X00035%2Fcov150h.gif |