Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progressi...

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Published inIEEE transactions on biomedical circuits and systems Vol. 14; no. 2; pp. 343 - 358
Main Authors Das, Rupam, Moradi, Farshad, Heidari, Hadi
Format Journal Article
LanguageEnglish
Published United States IEEE 01.04.2020
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Animal behavior
Animals
Biocompatibility
Biocompatible Materials
biointegration
Brain
Brain - physiology
Brain - surgery
Electrodes
Electroencephalography
Electrophysiological recording
Equipment Design
Flexible components
Humans
implantable neural device
Implantable Neurostimulators
Implantation
Implants
Inflammation
Materials Testing
mechanical flexibility
Mice
Neurons
Oscillations
Pliability
Probes
Recording
Spatiotemporal phenomena
Surgical implants
Wireless communication
wireless power transfer
Wireless Technology
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Abstract Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.
AbstractList Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.
Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.
Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.
Author Heidari, Hadi
Das, Rupam
Moradi, Farshad
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Snippet Implantable neural interfacing devices have added significantly to neural engineering by introducing the low-frequency oscillations of small populations of...
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SubjectTerms Animal behavior
Animals
Biocompatibility
Biocompatible Materials
biointegration
Brain
Brain - physiology
Brain - surgery
Electrodes
Electroencephalography
Electrophysiological recording
Equipment Design
Flexible components
Humans
implantable neural device
Implantable Neurostimulators
Implantation
Implants
Inflammation
Materials Testing
mechanical flexibility
Mice
Neurons
Oscillations
Pliability
Probes
Recording
Spatiotemporal phenomena
Surgical implants
Wireless communication
wireless power transfer
Wireless Technology
Title Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review
URI https://ieeexplore.ieee.org/document/8960457
https://www.ncbi.nlm.nih.gov/pubmed/31944987
https://www.proquest.com/docview/2384314381
https://www.proquest.com/docview/2341620173
Volume 14
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