How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?

• Published in: Biochimica et biophysica acta Vol. 1860; no. 6; pp. 1079 - 1088
• Main Author: Tajeddine, Nicolas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2016
• Subjects: Animals; Apoptosis; Calcium; Calcium - metabolism; cell death; cytotoxicity; Humans; Intrinsic pathway; ischemia; Mitochondria; mitochondrial membrane; Mitochondrial Membranes - metabolism; Mitochondrial permeabilisation; neoplasms; neurodegenerative diseases; Permeability; Reactive oxygen species; Reactive Oxygen Species - metabolism; NO; HKII; Reactive oxygen species; Intrinsic pathway; IP3R; Calcium; JNK; HTRA2; CypD; RyR; I/R; PTP; CaM; GSK-3β; RIRR; Mitochondria; ΔΨm; Mitochondrial permeabilisation; SMAC; FADD; MIMP; MOMP; MIMS; CAD; SOD; MOM; MAPK; SERCA; MIM; MMP; CaMKII; PC; DISC; ROS; MAM; IAP; Apoptosis

Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS...