How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?

Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1860; no. 6; pp. 1079 - 1088
Main Author Tajeddine, Nicolas
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2016
Subjects
Animals
Apoptosis
Calcium
Calcium - metabolism
cell death
cytotoxicity
Humans
Intrinsic pathway
ischemia
Mitochondria
mitochondrial membrane
Mitochondrial Membranes - metabolism
Mitochondrial permeabilisation
neoplasms
neurodegenerative diseases
Permeability
Reactive oxygen species
Reactive Oxygen Species - metabolism
NO
HKII
Reactive oxygen species
Intrinsic pathway
IP3R
Calcium
JNK
HTRA2
CypD
RyR
I/R
PTP
CaM
GSK-3β
RIRR
Mitochondria
ΔΨm
Mitochondrial permeabilisation
SMAC
FADD
MIMP
MOMP
MIMS
CAD
SOD
MOM
MAPK
SERCA
MIM
MMP
CaMKII
PC
DISC
ROS
MAM
IAP
Apoptosis
Online AccessGet full text

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Abstract Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS) and Ca2+ were the prominent inducers of MMP. However, the mechanisms connecting ROS and Ca2+ to the players of MMP are still a matter of debate. The aim of this review is to summarise the various studies related to the mechanisms of ROS- and Ca2+-induced MMP. Several lines of evidence suggest that ROS and Ca2+ cooperate to induce MMP but the molecular details of the ROS–Ca2+-MMP network remain controversial. We then discuss recent data depicting this topic. Cytotoxic stimuli may be transduced within the cell by ROS and Ca2+ increases. In most models, Ca2+ and ROS can cooperate to induce MMP. Moreover, several data suggest that MMP increases mitochondrial Ca2+ and ROS which therefore amplify the cytotoxic signal. Intriguingly, many reports have identified players of MMP as direct ROS targets. On the contrary, direct targets of Ca2+ remain elusive. At the same time, the mechanisms by which mitochondrial Ca2+ overload induces ROS generation are well documented. Upon these observations, we hypothesise that Ca2+ cannot directly induce MMP and requires ROS production as a mandatory step. Given the importance of Ca2+- and ROS-induced MMP in diseases, we expect that a better understanding of this process will lead to the development of novel therapies. •Mitochondrial membrane permeabilisation (MMP) is a crucial step leading to cell death.•In most models, ROS and mitochondrial Ca2+ cooperate to induce MMP.•ROS directly target several components involved in MMP.•However, the mechanisms by which mitochondrial Ca2+ induces MMP remain obscure.•Ca2+ might require mitochondrial ROS generation as a mandatory step to trigger MMP.
AbstractList Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS) and Ca(2+) were the prominent inducers of MMP. However, the mechanisms connecting ROS and Ca(2+) to the players of MMP are still a matter of debate. The aim of this review is to summarise the various studies related to the mechanisms of ROS- and Ca(2+)-induced MMP. Several lines of evidence suggest that ROS and Ca(2+) cooperate to induce MMP but the molecular details of the ROS-Ca(2+)-MMP network remain controversial. We then discuss recent data depicting this topic. Cytotoxic stimuli may be transduced within the cell by ROS and Ca(2+) increases. In most models, Ca(2+) and ROS can cooperate to induce MMP. Moreover, several data suggest that MMP increases mitochondrial Ca(2+) and ROS which therefore amplify the cytotoxic signal. Intriguingly, many reports have identified players of MMP as direct ROS targets. On the contrary, direct targets of Ca(2+) remain elusive. At the same time, the mechanisms by which mitochondrial Ca(2+) overload induces ROS generation are well documented. Upon these observations, we hypothesise that Ca(2+) cannot directly induce MMP and requires ROS production as a mandatory step. Given the importance of Ca(2+)- and ROS-induced MMP in diseases, we expect that a better understanding of this process will lead to the development of novel therapies.
BACKGROUNDMitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS) and Ca(2+) were the prominent inducers of MMP. However, the mechanisms connecting ROS and Ca(2+) to the players of MMP are still a matter of debate.SCOPE OF REVIEWThe aim of this review is to summarise the various studies related to the mechanisms of ROS- and Ca(2+)-induced MMP. Several lines of evidence suggest that ROS and Ca(2+) cooperate to induce MMP but the molecular details of the ROS-Ca(2+)-MMP network remain controversial. We then discuss recent data depicting this topic.MAJOR CONCLUSIONSCytotoxic stimuli may be transduced within the cell by ROS and Ca(2+) increases. In most models, Ca(2+) and ROS can cooperate to induce MMP. Moreover, several data suggest that MMP increases mitochondrial Ca(2+) and ROS which therefore amplify the cytotoxic signal. Intriguingly, many reports have identified players of MMP as direct ROS targets. On the contrary, direct targets of Ca(2+) remain elusive. At the same time, the mechanisms by which mitochondrial Ca(2+) overload induces ROS generation are well documented. Upon these observations, we hypothesise that Ca(2+) cannot directly induce MMP and requires ROS production as a mandatory step.GENERAL SIGNIFICANCEGiven the importance of Ca(2+)- and ROS-induced MMP in diseases, we expect that a better understanding of this process will lead to the development of novel therapies.
Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS) and Ca2+ were the prominent inducers of MMP. However, the mechanisms connecting ROS and Ca2+ to the players of MMP are still a matter of debate. The aim of this review is to summarise the various studies related to the mechanisms of ROS- and Ca2+-induced MMP. Several lines of evidence suggest that ROS and Ca2+ cooperate to induce MMP but the molecular details of the ROS–Ca2+-MMP network remain controversial. We then discuss recent data depicting this topic. Cytotoxic stimuli may be transduced within the cell by ROS and Ca2+ increases. In most models, Ca2+ and ROS can cooperate to induce MMP. Moreover, several data suggest that MMP increases mitochondrial Ca2+ and ROS which therefore amplify the cytotoxic signal. Intriguingly, many reports have identified players of MMP as direct ROS targets. On the contrary, direct targets of Ca2+ remain elusive. At the same time, the mechanisms by which mitochondrial Ca2+ overload induces ROS generation are well documented. Upon these observations, we hypothesise that Ca2+ cannot directly induce MMP and requires ROS production as a mandatory step. Given the importance of Ca2+- and ROS-induced MMP in diseases, we expect that a better understanding of this process will lead to the development of novel therapies. •Mitochondrial membrane permeabilisation (MMP) is a crucial step leading to cell death.•In most models, ROS and mitochondrial Ca2+ cooperate to induce MMP.•ROS directly target several components involved in MMP.•However, the mechanisms by which mitochondrial Ca2+ induces MMP remain obscure.•Ca2+ might require mitochondrial ROS generation as a mandatory step to trigger MMP.
Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous diseases such as cancer, neurodegenerative disorders or ischemia/reperfusion injuries. Many studies established that reactive oxygen species (ROS) and Ca²⁺ were the prominent inducers of MMP. However, the mechanisms connecting ROS and Ca²⁺ to the players of MMP are still a matter of debate.The aim of this review is to summarise the various studies related to the mechanisms of ROS- and Ca²⁺-induced MMP. Several lines of evidence suggest that ROS and Ca²⁺ cooperate to induce MMP but the molecular details of the ROS–Ca²⁺-MMP network remain controversial. We then discuss recent data depicting this topic.Cytotoxic stimuli may be transduced within the cell by ROS and Ca²⁺ increases. In most models, Ca²⁺ and ROS can cooperate to induce MMP. Moreover, several data suggest that MMP increases mitochondrial Ca²⁺ and ROS which therefore amplify the cytotoxic signal. Intriguingly, many reports have identified players of MMP as direct ROS targets. On the contrary, direct targets of Ca²⁺ remain elusive. At the same time, the mechanisms by which mitochondrial Ca²⁺ overload induces ROS generation are well documented. Upon these observations, we hypothesise that Ca²⁺ cannot directly induce MMP and requires ROS production as a mandatory step.Given the importance of Ca²⁺- and ROS-induced MMP in diseases, we expect that a better understanding of this process will lead to the development of novel therapies.
Author Tajeddine, Nicolas
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  organization: Laboratory of Cell Physiology, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium
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Cites_doi 10.1016/j.bbabio.2009.12.006
10.1128/MCB.22.7.2099-2110.2002
10.1016/j.molcel.2005.06.009
10.3233/JAD-2010-100465
10.1113/jphysiol.2007.145409
10.1126/science.1099320
10.1038/nature07986
10.4061/2011/920178
10.1073/pnas.0408352102
10.1016/j.mito.2014.07.009
10.1073/pnas.220413597
10.1371/journal.pone.0002718
10.1016/S0021-9258(17)33220-9
10.1126/science.1081208
10.1161/CIRCRESAHA.112.265942
10.1152/ajpcell.00207.2006
10.1126/science.1059108
10.1016/j.febslet.2007.03.003
10.1016/j.ceca.2011.05.011
10.1038/onc.2008.63
10.1083/jcb.200608073
10.1038/bjc.1972.33
10.3389/fonc.2014.00302
10.1093/carcin/bgl051
10.1073/pnas.74.10.4360
10.1016/0006-291X(91)91256-C
10.1038/35040009
10.1016/S0006-291X(03)00618-1
10.1089/ars.2006.8.1775
10.1002/pros.2990170302
10.1074/jbc.C500089200
10.1074/jbc.M112355200
10.1038/sj.cdd.4401908
10.1161/hh1201.093159
10.1016/j.phrs.2015.04.013
10.1152/physrev.00018.2001
10.1038/onc.2008.114
10.1016/0165-6147(89)90029-1
10.1038/35037710
10.1016/S0014-5793(01)02316-X
10.1084/jem.181.5.1661
10.1073/pnas.0912742107
10.1016/j.yjmcc.2008.12.022
10.1016/S0014-5793(97)01235-0
10.1074/jbc.M305870200
10.1038/nature10234
10.1021/bi00198a019
10.1038/nature10230
10.1073/pnas.1401591111
10.1016/j.bbabio.2011.11.006
10.1096/fj.01-0269fje
10.1074/jbc.M112.400754
10.1038/sj.onc.1207747
10.1084/jem.187.8.1261
10.1074/jbc.270.49.29548
10.1089/ars.2010.3359
10.1096/fasebj.14.2.355
10.1016/j.cell.2004.12.041
10.1007/s10557-010-6234-z
10.1074/jbc.M113.504159
10.1113/jphysiol.2013.260521
10.1016/S0021-9258(20)80665-6
10.1074/jbc.M111.276089
10.1016/S0005-2728(96)00111-9
10.1038/nrm1155
10.1074/jbc.M507611200
10.1038/nature11444
10.1084/jem.182.2.367
10.1158/0008-5472.CAN-05-1925
10.1038/ncomms7580
10.2217/fca.12.58
10.1016/B978-0-12-386033-0.00002-5
10.1073/pnas.1410723112
10.1038/sj.cdd.4401571
10.1016/j.mito.2012.07.112
10.1080/09687860600907644
10.1126/science.1092734
10.1016/j.ceca.2007.11.015
10.1101/cshperspect.a008706
10.1038/nrn2665
10.1042/BJ20141291
10.1136/jcp.54.3.176
10.1042/BJ20041142
10.1111/j.1749-6632.1999.tb09255.x
10.1016/j.cell.2012.05.014
10.1038/sj.onc.1204575
10.1074/jbc.M110.188516
10.1152/ajpheart.00997.2010
10.1007/s00204-014-1219-5
10.1016/j.ceb.2009.08.005
10.1128/MCB.19.12.8469
10.1016/j.niox.2011.12.007
10.1016/j.bbabio.2010.02.010
10.1016/S0092-8674(04)00046-7
10.1038/nature03317
10.1038/35036395
10.1038/ncb1123
10.1002/ijc.25204
10.1073/pnas.0438011100
10.1016/j.plipres.2014.04.001
10.1073/pnas.1504705112
10.1016/j.carrev.2014.12.010
10.1172/JCI19906
10.1016/S0005-2728(00)00248-6
10.1074/jbc.M208705200
10.1073/pnas.1217823110
10.1016/j.bbabio.2010.03.010
10.1152/ajpcell.00139.2004
10.1038/cdd.2009.61
10.1038/cddis.2013.522
10.3389/fphys.2013.00076
10.1152/physrev.00026.2013
10.1111/j.1749-6632.2010.05634.x
10.1161/CIRCRESAHA.114.300559
10.1126/scisignal.2000672
10.1016/j.ceca.2014.06.002
10.1080/09537100600745187
10.1523/JNEUROSCI.23-36-11373.2003
10.1016/j.yjmcc.2007.08.010
10.1016/j.molcel.2006.02.009
10.1074/jbc.M808750200
10.1073/pnas.0505294102
10.1177/1534735404270335
10.1038/nature03434
10.1016/0092-8674(95)90412-3
10.1016/j.bbrc.2014.12.036
10.1016/j.bbabio.2012.06.007
10.1016/0014-5793(92)80914-3
10.1038/sj.cdd.4402147
10.1016/j.freeradbiomed.2008.01.011
10.1152/physrev.00001.2015
10.1083/jcb.200604016
10.1038/onc.2008.308
10.1016/S1097-2765(03)00050-9
10.1038/nsmb.2284
10.1038/cdd.2011.96
10.1038/sj.cdd.4401830
10.1152/physrev.00013.2006
10.1038/nrm2256
10.1158/0008-5472.CAN-07-2931
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Issue 6
Keywords NO
HKII
Reactive oxygen species
Intrinsic pathway
IP3R
Calcium
JNK
HTRA2
CypD
RyR
I/R
PTP
CaM
GSK-3β
RIRR
Mitochondria
ΔΨm
Mitochondrial permeabilisation
SMAC
FADD
MIMP
MOMP
MIMS
CAD
SOD
MOM
MAPK
SERCA
MIM
MMP
CaMKII
PC
DISC
ROS
MAM
IAP
Apoptosis
Language English
License Copyright © 2016 Elsevier B.V. All rights reserved.
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References Giorgio, Soriano, Basso, Bisetto, Lippe, Forte, Bernardi (bb0150) 2010; 1797
Zundorf, Reiser (bb0660) 2011; 14
Brookes, Yoon, Robotham, Anders, Sheu (bb0690) 2004; 287
Malis, Bonventre (bb0230) 1988; 282
Tiwari, Kumar, Sinha, Shrivastava, Balapure, Sharma, Bajpai, Mitra, Babu, Godbole (bb0535) 2006; 27
Odagiri, Katoh, Kawashima, Tanaka, Ohtani, Saotome, Urushida, Satoh, Hayashi (bb0685) 2009; 46
Marzo, Brenner, Zamzami, Susin, Beutner, Brdiczka, Remy, Xie, Reed, Kroemer (bb0090) 1998; 187
Young, Woodside (bb0225) 2001; 54
Fang, Yu, Tanyi, Lu, Woodgett, Mills (bb0455) 2002; 22
Nakagawa, Shimizu, Watanabe, Yamaguchi, Otsu, Yamagata, Inohara, Kubo, Tsujimoto (bb0140) 2005; 434
Rasola, Sciacovelli, Chiara, Pantic, Brusilow, Bernardi (bb0495) 2010; 107
Arakaki, Ueyama, Hirose, Himeda, Shibata, Futaki, Kitagawa, Higuti (bb0575) 2001; 1504
Zamzami, Marchetti, Castedo, Decaudin, Macho, Hirsch, Susin, Petit, Mignotte, Kroemer (bb0005) 1995; 182
Win, Than, Han, Petrovic, Kaplowitz (bb0415) 2011; 286
Bansaghi, Golenar, Madesh, Csordas, RamachandraRao, Sharma, Yule, Joseph, Hajnoczky (bb0635) 2014; 289
Ha, Shin, Yoon, Lee, He, Bae, Yoon, Lee, Park, Muto, Chi (bb0350) 2013; 288
Pinton, Giorgi, Siviero, Zecchini, Rizzuto (bb0545) 2008; 27
Kerr, Wyllie, Currie (bb0015) 1972; 26
Javadov, Kuznetsov (bb0280) 2013; 4
Kohr, Aponte, Sun, Wang, Murphy, Gucek, Steenbergen (bb0290) 2011; 300
Baughman, Perocchi, Girgis, Plovanich, Belcher-Timme, Sancak, Bao, Strittmatter, Goldberger, Bogorad, Koteliansky, Mootha (bb0560) 2011; 476
Nakano, Nakajima, Sakon-Komazawa, Piao, Xue, Okumura (bb0400) 2006; 13
Tan, Fujimoto, Takii, Takaki, Hayashida, Nakai (bb0170) 2015; 6
Gonzalvez, Pariselli, Dupaigne, Budihardjo, Lutter, Antonsson, Diolez, Manon, Martinou, Goubern, Wang, Bernard, Petit (bb0380) 2005; 12
Green, Kroemer (bb0040) 2004; 305
D'Autreaux, Toledano (bb0190) 2007; 8
Duan, Gross, Sheu (bb0695) 2007; 585
Mattson (bb0025) 2000; 1
Danial, Korsmeyer (bb0065) 2004; 116
Bhakar, Howell, Paul, Salehi, Becker, Said, Bonni, Barker (bb0440) 2003; 23
Adam-Vizi, Starkov (bb0675) 2010; 20
Bernardi, Rasola, Forte, Lippe (bb0110) 2015; 95
Dolder, Walzel, Speer, Schlattner, Wallimann (bb0125) 2003; 278
Tomita, Marchenko, Erster, Nemajerova, Dehner, Klein, Pan, Kessler, Pancoska, Moll (bb0355) 2006; 281
Chen, Zweier (bb0215) 2014; 114
Giorgio, von Stockum, Antoniel, Fabbro, Fogolari, Forte, Glick, Petronilli, Zoratti, Szabo, Lippe, Bernardi (bb0155) 2013; 110
Sanz-Blasco, Valero, Rodriguez-Crespo, Villalobos, Nunez (bb0705) 2008; 3
Oakes, Scorrano, Opferman, Bassik, Nishino, Pozzan, Korsmeyer (bb0620) 2005; 102
Galluzzi, Kepp, Tajeddine, Kroemer (bb0120) 2008; 27
Martel, Wang, Brenner (bb0245) 2014; 19 Pt A
Kamata, Honda, Maeda, Chang, Hirata, Karin (bb0395) 2005; 120
Kowaltowski, Vercesi, Castilho (bb0240) 1997; 1318
Aoki, Kang, Hampe, Yoshimura, Noma, Matsuzaki, Izumo (bb0410) 2002; 277
Kroemer, Galluzzi, Brenner (bb0055) 2007; 87
Chipuk, Green (bb0305) 2006; 13
Martikainen, Isaacs (bb0515) 1990; 17
Peng, Jou (bb0670) 2010; 1201
Zhang, Han, Qi, Cheng, Ma, Hou, Cao, Wang (bb0665) 2015; 456
Neuzil, Dong, Rohlena, Truksa, Ralph (bb0715) 2013; 13
Leu, Dumont, Hafey, Murphy, George (bb0335) 2004; 6
De Stefani, Raffaello, Teardo, Szabo, Rizzuto (bb0555) 2011; 476
Schinzel, Takeuchi, Huang, Fisher, Zhou, Rubens, Hetz, Danial, Moskowitz, Korsmeyer (bb0130) 2005; 102
Orrenius, McConkey, Bellomo, Nicotera (bb0510) 1989; 10
Webster (bb0630) 2012; 8
Watcharasit, Bijur, Song, Zhu, Chen, Jope (bb0480) 2003; 278
De Giorgi, Lartigue, Bauer, Schubert, Grimm, Hanson, Remington, Youle, Ichas (bb0075) 2002; 16
Juhaszova, Zorov, Kim, Pepe, Fu, Fishbein, Ziman, Wang, Ytrehus, Antos, Olson, Sollott (bb0470) 2004; 113
Win, Than, Fernandez-Checa, Kaplowitz (bb0420) 2014; 5
Eliseev, Malecki, Lester, Zhang, Humphrey, Gunter (bb0095) 2009; 284
Williams, Waksman, De Silva, Jacques, Mahmoudi (bb0490) 2015; 16
Kowaltowski, Castilho, Vercesi (bb0235) 2001; 495
Joiner, Koval, Li, He, Allamargot, Gao, Luczak, Hall, Fink, Chen, Yang, Moore, Scholz, Strack, Mohler, Sivitz, Song, Anderson (bb0595) 2012; 491
Ding, Xia, Liu, Yang, Lee, Xia, Bartholomeusz, Li, Pan, Li, Bargou, Qin, Lai, Tsai, Tsai, Hung (bb0465) 2005; 19
Berridge, Bootman, Roderick (bb0505) 2003; 4
Bonora, Pinton (bb0580) 2014; 4
Marques-da-Silva, Gutierrez-Merino (bb0650) 2014; 56
Ren, Phoon, Schlame (bb0360) 2014; 55
Hengartner (bb0045) 2000; 407
Anson, Hudson, Bohr (bb0220) 2000; 14
Liu, Chen, Clair (bb0300) 2008; 44
Nishihara, Miura, Miki, Tanno, Yano, Naitoh, Ohori, Hotta, Terashima, Shimamoto (bb0485) 2007; 43
Lutter, Fang, Luo, Nishijima, Xie, Wang (bb0375) 2000; 2
Spat, Szanda, Csordas, Hajnoczky (bb0565) 2008; 44
Toledo, Perez, Basiglio, Ochoa, Sanchez Pozzi, Roma (bb0605) 2014; 88
Bogeski, Kummerow, Al-Ansary, Schwarz, Koehler, Kozai, Takahashi, Peinelt, Griesemer, Bozem, Mori, Hoth, Niemeyer (bb0645) 2010; 3
Sen, D'Incalci (bb0020) 1992; 307
Symersky, Pagadala, Osowski, Krah, Meier, Faraldo-Gomez, Mueller (bb0570) 2012; 19
Galluzzi, Blomgren, Kroemer (bb0085) 2009; 10
Hunter, Haworth, Southard (bb0525) 1976; 251
Arrington, Van Vleet, Schnellmann (bb0585) 2006; 291
Vaseva, Marchenko, Ji, Tsirka, Holzmann, Moll (bb0295) 2012; 149
Maurer, Charvet, Wagman, Dejardin, Green (bb0115) 2006; 21
Majima, Koike, Hong, Shinohara, Terada (bb0255) 1993; 268
Fujimoto, Hayashi (bb0540) 2011; 292
Korytowski, Basova, Pilat, Kernstock, Girotti (bb0385) 2011; 286
Jonas, Porter, Beutner, Mnatsakanyan, Alavian (bb0165) 2015; 99
Pastorino, Hoek, Shulga (bb0475) 2005; 65
Fuentes-Prior, Salvesen (bb0035) 2004; 384
Distelhorst, Bootman (bb0615) 2011; 50
Wei, Zong, Cheng, Lindsten, Panoutsakopoulou, Ross, Roth, MacGregor, Thompson, Korsmeyer (bb0060) 2001; 292
Montero, Mari, Colell, Morales, Basanez, Garcia-Ruiz, Fernandez-Checa (bb0365) 2010; 1797
Giacomello, Drago, Pizzo, Pozzan (bb0520) 2007; 14
Szabadkai, Bianchi, Varnai, De Stefani, Wieckowski, Cavagna, Nagy, Balla, Rizzuto (bb0550) 2006; 175
Droge (bb0185) 2002; 82
Scorrano, Oakes, Opferman, Cheng, Sorcinelli, Pozzan, Korsmeyer (bb0625) 2003; 300
Yamamoto, Ichijo, Korsmeyer (bb0430) 1999; 19
Basso, Fante, Fowlkes, Petronilli, Forte, Bernardi (bb0145) 2005; 280
Lippe, Comelli, Mazzilis, Sala, Mavelli (bb0315) 1991; 181
Buchert, Schober, Rompp, Richter, Forreiter (bb0320) 2012; 1817
Li, Abdel Fattah, Cao, Ren, Yang, Goltsov, Chinault, Cai, Timme, Thompson (bb0390) 2008; 68
Xiao, Choi, Johnson, Vogel, Johnson, Trump, Lee, Singh (bb0425) 2004; 23
Chipuk, Kuwana, Bouchier-Hayes, Droin, Newmeyer, Schuler, Green (bb0340) 2004; 303
Shaw, Cohen, Alessi (bb0450) 1997; 416
Le Bras, Clement, Pervaiz, Brenner (bb0250) 2005; 20
Csordas, Renken, Varnai, Walter, Weaver, Buttle, Balla, Mannella, Hajnoczky (bb0530) 2006; 174
Ohtani, Katoh, Tanaka, Saotome, Urushida, Satoh, Hayashi (bb0285) 2012; 26
Gogvadze, Norberg, Orrenius, Zhivotovsky (bb0720) 2010; 127
Baines, Kaiser, Purcell, Blair, Osinska, Hambleton, Brunskill, Sayen, Gottlieb, Dorn, Robbins, Molkentin (bb0135) 2005; 434
Gottlieb, Engler (bb0030) 1999; 874
Green, Kroemer (bb0310) 2009; 458
Fang, Yu, Lu, Bast, Woodgett, Mills (bb0460) 2000; 97
Komary, Tretter, Adam-Vizi (bb0680) 2010; 1797
Majima, Ikawa, Takeda, Hashimoto, Shinohara, Terada (bb0265) 1995; 270
Galluzzi, Vitale, Abrams, Alnemri, Baehrecke, Blagosklonny, Dawson, Dawson, El-Deiry, Fulda, Gottlieb, Green, Hengartner, Kepp, Knight, Kumar, Lipton, Lu, Madeo, Malorni, Mehlen, Nunez, Peter, Piacentini, Rubinsztein, Shi, Simon, Vandenabeele, White, Yuan, Zhivotovsky, Melino, Kroemer (bb0180) 2012; 19
Liu, Templeton (bb0610) 2007; 581
Miyashita, Reed (bb0330) 1995; 80
Shamas-Din, Bindner, Chi, Leber, Andrews, Fradin (bb0370) 2015; 467
Rasmussen, Wu, Joiner, Koval, Wilson, Luczak, Wang, Chen, Gao, Zhu, Wagner, Soto, McCormick, Kutschke, Weiss, Yu, Boudreau, Abel, Zhan, Spitz, Buettner, Song, Zingman, Anderson (bb0700) 2015; 112
Giorgi, Bonora, Sorrentino, Missiroli, Poletti, Suski, Galindo Ramirez, Rizzuto, Di Virgilio, Zito, Pandolfi, Wieckowski, Mammano, Del Sal, Pinton (bb0710) 2015; 112
Conklin (bb0205) 2004; 3
Zamzami, Marchetti, Castedo, Zanin, Vayssiere, Petit, Kroemer (bb0010) 1995; 181
Molkentin (bb0600) 2001; 88
Itano, Matsui, Doi, Ohmura, Hatase (bb0590) 1986; 13
Belzacq, Vieira, Verrier, Vandecasteele, Cohen, Prevost, Larquet, Pariselli, Petit, Kahn, Rizzuto, Brenner, Kroemer (bb0080) 2003; 63
Zorov, Juhaszova, Sollott (bb0210) 2014; 94
McCubrey, Lahair, Franklin (bb0405) 2006; 8
Tajeddine, Galluzzi, Kepp, Hangen, Morselli, Senovilla, Araujo, Pinna, Larochette, Zamzami, Modjtahedi, Harel-Bellan, Kroemer (bb0105) 2008; 27
De Marchi, Basso, Szabo, Zoratti (bb0275) 2006; 23
Decuypere, Monaco, Missiaen, De Smedt, Parys, Bultynck (bb0500) 2011; 2011
Vieira, Belzacq, Haouzi, Bernassola, Cohen, Jacotot, Ferri, El Hamel, Bartle, Melino, Brenner, Goldmacher, Kroemer (bb0270) 2001; 20
Mihara, Erster, Zaika, Petrenko, Chittenden, Pancoska, Moll (bb0345) 2003; 11
Kim, He, Lemasters (bb0175) 2003; 304
Lei, Davis (bb0435) 2003; 100
Tait, Green (bb0050) 2013; 5
Jardin, Redondo, Salido, Pariente, Rosado (bb0655) 2006; 17
Cooper, Li, Lu, Centracchio, Terentyeva, Koren, Terentyev (bb0640) 2013; 591
Ott, Norberg, Zhivotovsky, Orrenius (bb0070) 2009; 16
Brenner, Moulin (bb0100) 2012; 111
Alavian, Beutner, Lazrove, Sacchetti, Park, Licznerski, Li, Nabili, Hockensmith, Graham, Porter, Jonas (bb0160) 2014; 111
Miura, Tanno (bb0445) 2010; 24
Hamanaka, Chandel (bb0200) 2009; 21
Majima, Shinohara, Yamaguchi, Hong, Terada (bb0260) 1994; 33
Rexroth, Poetsch, Rogner, Hamann, Werner, Osiewacz, Schafer, Seelert, Dencher (bb0325) 2012; 1817
Mittal, Murad (bb0195) 1977; 74
Win (10.1016/j.bbagen.2016.02.013_bb0415) 2011; 286
Bansaghi (10.1016/j.bbagen.2016.02.013_bb0635) 2014; 289
Oakes (10.1016/j.bbagen.2016.02.013_bb0620) 2005; 102
Kerr (10.1016/j.bbagen.2016.02.013_bb0015) 1972; 26
Scorrano (10.1016/j.bbagen.2016.02.013_bb0625) 2003; 300
Malis (10.1016/j.bbagen.2016.02.013_bb0230) 1988; 282
Basso (10.1016/j.bbagen.2016.02.013_bb0145) 2005; 280
Bogeski (10.1016/j.bbagen.2016.02.013_bb0645) 2010; 3
Baines (10.1016/j.bbagen.2016.02.013_bb0135) 2005; 434
Korytowski (10.1016/j.bbagen.2016.02.013_bb0385) 2011; 286
Kim (10.1016/j.bbagen.2016.02.013_bb0175) 2003; 304
Mihara (10.1016/j.bbagen.2016.02.013_bb0345) 2003; 11
Shamas-Din (10.1016/j.bbagen.2016.02.013_bb0370) 2015; 467
Kowaltowski (10.1016/j.bbagen.2016.02.013_bb0235) 2001; 495
Belzacq (10.1016/j.bbagen.2016.02.013_bb0080) 2003; 63
Maurer (10.1016/j.bbagen.2016.02.013_bb0115) 2006; 21
Zamzami (10.1016/j.bbagen.2016.02.013_bb0010) 1995; 181
Liu (10.1016/j.bbagen.2016.02.013_bb0300) 2008; 44
Hengartner (10.1016/j.bbagen.2016.02.013_bb0045) 2000; 407
Young (10.1016/j.bbagen.2016.02.013_bb0225) 2001; 54
Wei (10.1016/j.bbagen.2016.02.013_bb0060) 2001; 292
Marques-da-Silva (10.1016/j.bbagen.2016.02.013_bb0650) 2014; 56
De Stefani (10.1016/j.bbagen.2016.02.013_bb0555) 2011; 476
Giorgio (10.1016/j.bbagen.2016.02.013_bb0150) 2010; 1797
Giorgi (10.1016/j.bbagen.2016.02.013_bb0710) 2015; 112
Neuzil (10.1016/j.bbagen.2016.02.013_bb0715) 2013; 13
Galluzzi (10.1016/j.bbagen.2016.02.013_bb0180) 2012; 19
Tan (10.1016/j.bbagen.2016.02.013_bb0170) 2015; 6
Tait (10.1016/j.bbagen.2016.02.013_bb0050) 2013; 5
Le Bras (10.1016/j.bbagen.2016.02.013_bb0250) 2005; 20
Watcharasit (10.1016/j.bbagen.2016.02.013_bb0480) 2003; 278
Buchert (10.1016/j.bbagen.2016.02.013_bb0320) 2012; 1817
Martikainen (10.1016/j.bbagen.2016.02.013_bb0515) 1990; 17
Hunter (10.1016/j.bbagen.2016.02.013_bb0525) 1976; 251
Adam-Vizi (10.1016/j.bbagen.2016.02.013_bb0675) 2010; 20
Arrington (10.1016/j.bbagen.2016.02.013_bb0585) 2006; 291
Cooper (10.1016/j.bbagen.2016.02.013_bb0640) 2013; 591
De Giorgi (10.1016/j.bbagen.2016.02.013_bb0075) 2002; 16
Nakagawa (10.1016/j.bbagen.2016.02.013_bb0140) 2005; 434
Lei (10.1016/j.bbagen.2016.02.013_bb0435) 2003; 100
Yamamoto (10.1016/j.bbagen.2016.02.013_bb0430) 1999; 19
Bhakar (10.1016/j.bbagen.2016.02.013_bb0440) 2003; 23
Pinton (10.1016/j.bbagen.2016.02.013_bb0545) 2008; 27
Gottlieb (10.1016/j.bbagen.2016.02.013_bb0030) 1999; 874
Danial (10.1016/j.bbagen.2016.02.013_bb0065) 2004; 116
Joiner (10.1016/j.bbagen.2016.02.013_bb0595) 2012; 491
Marzo (10.1016/j.bbagen.2016.02.013_bb0090) 1998; 187
Fujimoto (10.1016/j.bbagen.2016.02.013_bb0540) 2011; 292
Duan (10.1016/j.bbagen.2016.02.013_bb0695) 2007; 585
Eliseev (10.1016/j.bbagen.2016.02.013_bb0095) 2009; 284
Tajeddine (10.1016/j.bbagen.2016.02.013_bb0105) 2008; 27
Aoki (10.1016/j.bbagen.2016.02.013_bb0410) 2002; 277
D'Autreaux (10.1016/j.bbagen.2016.02.013_bb0190) 2007; 8
Mittal (10.1016/j.bbagen.2016.02.013_bb0195) 1977; 74
Komary (10.1016/j.bbagen.2016.02.013_bb0680) 2010; 1797
Molkentin (10.1016/j.bbagen.2016.02.013_bb0600) 2001; 88
Majima (10.1016/j.bbagen.2016.02.013_bb0265) 1995; 270
Ott (10.1016/j.bbagen.2016.02.013_bb0070) 2009; 16
Fuentes-Prior (10.1016/j.bbagen.2016.02.013_bb0035) 2004; 384
Majima (10.1016/j.bbagen.2016.02.013_bb0260) 1994; 33
Anson (10.1016/j.bbagen.2016.02.013_bb0220) 2000; 14
De Marchi (10.1016/j.bbagen.2016.02.013_bb0275) 2006; 23
Williams (10.1016/j.bbagen.2016.02.013_bb0490) 2015; 16
Shaw (10.1016/j.bbagen.2016.02.013_bb0450) 1997; 416
Green (10.1016/j.bbagen.2016.02.013_bb0310) 2009; 458
Droge (10.1016/j.bbagen.2016.02.013_bb0185) 2002; 82
Tiwari (10.1016/j.bbagen.2016.02.013_bb0535) 2006; 27
Fang (10.1016/j.bbagen.2016.02.013_bb0460) 2000; 97
Conklin (10.1016/j.bbagen.2016.02.013_bb0205) 2004; 3
Bernardi (10.1016/j.bbagen.2016.02.013_bb0110) 2015; 95
Brookes (10.1016/j.bbagen.2016.02.013_bb0690) 2004; 287
Juhaszova (10.1016/j.bbagen.2016.02.013_bb0470) 2004; 113
Leu (10.1016/j.bbagen.2016.02.013_bb0335) 2004; 6
Arakaki (10.1016/j.bbagen.2016.02.013_bb0575) 2001; 1504
Chipuk (10.1016/j.bbagen.2016.02.013_bb0340) 2004; 303
Majima (10.1016/j.bbagen.2016.02.013_bb0255) 1993; 268
Kamata (10.1016/j.bbagen.2016.02.013_bb0395) 2005; 120
Zamzami (10.1016/j.bbagen.2016.02.013_bb0005) 1995; 182
Csordas (10.1016/j.bbagen.2016.02.013_bb0530) 2006; 174
Chen (10.1016/j.bbagen.2016.02.013_bb0215) 2014; 114
Miyashita (10.1016/j.bbagen.2016.02.013_bb0330) 1995; 80
Odagiri (10.1016/j.bbagen.2016.02.013_bb0685) 2009; 46
Lutter (10.1016/j.bbagen.2016.02.013_bb0375) 2000; 2
Berridge (10.1016/j.bbagen.2016.02.013_bb0505) 2003; 4
Distelhorst (10.1016/j.bbagen.2016.02.013_bb0615) 2011; 50
Spat (10.1016/j.bbagen.2016.02.013_bb0565) 2008; 44
Rasmussen (10.1016/j.bbagen.2016.02.013_bb0700) 2015; 112
Ding (10.1016/j.bbagen.2016.02.013_bb0465) 2005; 19
Webster (10.1016/j.bbagen.2016.02.013_bb0630) 2012; 8
Jonas (10.1016/j.bbagen.2016.02.013_bb0165) 2015; 99
Vieira (10.1016/j.bbagen.2016.02.013_bb0270) 2001; 20
Rexroth (10.1016/j.bbagen.2016.02.013_bb0325) 2012; 1817
Itano (10.1016/j.bbagen.2016.02.013_bb0590) 1986; 13
Kohr (10.1016/j.bbagen.2016.02.013_bb0290) 2011; 300
Hamanaka (10.1016/j.bbagen.2016.02.013_bb0200) 2009; 21
Zorov (10.1016/j.bbagen.2016.02.013_bb0210) 2014; 94
Win (10.1016/j.bbagen.2016.02.013_bb0420) 2014; 5
Bonora (10.1016/j.bbagen.2016.02.013_bb0580) 2014; 4
Peng (10.1016/j.bbagen.2016.02.013_bb0670) 2010; 1201
Giorgio (10.1016/j.bbagen.2016.02.013_bb0155) 2013; 110
Xiao (10.1016/j.bbagen.2016.02.013_bb0425) 2004; 23
Gonzalvez (10.1016/j.bbagen.2016.02.013_bb0380) 2005; 12
Gogvadze (10.1016/j.bbagen.2016.02.013_bb0720) 2010; 127
Toledo (10.1016/j.bbagen.2016.02.013_bb0605) 2014; 88
Sanz-Blasco (10.1016/j.bbagen.2016.02.013_bb0705) 2008; 3
Martel (10.1016/j.bbagen.2016.02.013_bb0245) 2014; 19 Pt A
Szabadkai (10.1016/j.bbagen.2016.02.013_bb0550) 2006; 175
Ren (10.1016/j.bbagen.2016.02.013_bb0360) 2014; 55
Schinzel (10.1016/j.bbagen.2016.02.013_bb0130) 2005; 102
Jardin (10.1016/j.bbagen.2016.02.013_bb0655) 2006; 17
Galluzzi (10.1016/j.bbagen.2016.02.013_bb0120) 2008; 27
Kroemer (10.1016/j.bbagen.2016.02.013_bb0055) 2007; 87
Kowaltowski (10.1016/j.bbagen.2016.02.013_bb0240) 1997; 1318
Lippe (10.1016/j.bbagen.2016.02.013_bb0315) 1991; 181
Mattson (10.1016/j.bbagen.2016.02.013_bb0025) 2000; 1
Nakano (10.1016/j.bbagen.2016.02.013_bb0400) 2006; 13
Nishihara (10.1016/j.bbagen.2016.02.013_bb0485) 2007; 43
Pastorino (10.1016/j.bbagen.2016.02.013_bb0475) 2005; 65
Rasola (10.1016/j.bbagen.2016.02.013_bb0495) 2010; 107
Li (10.1016/j.bbagen.2016.02.013_bb0390) 2008; 68
Zundorf (10.1016/j.bbagen.2016.02.013_bb0660) 2011; 14
Vaseva (10.1016/j.bbagen.2016.02.013_bb0295) 2012; 149
Giacomello (10.1016/j.bbagen.2016.02.013_bb0520) 2007; 14
Baughman (10.1016/j.bbagen.2016.02.013_bb0560) 2011; 476
Alavian (10.1016/j.bbagen.2016.02.013_bb0160) 2014; 111
McCubrey (10.1016/j.bbagen.2016.02.013_bb0405) 2006; 8
Sen (10.1016/j.bbagen.2016.02.013_bb0020) 1992; 307
Miura (10.1016/j.bbagen.2016.02.013_bb0445) 2010; 24
Decuypere (10.1016/j.bbagen.2016.02.013_bb0500) 2011; 2011
Brenner (10.1016/j.bbagen.2016.02.013_bb0100) 2012; 111
Orrenius (10.1016/j.bbagen.2016.02.013_bb0510) 1989; 10
Ha (10.1016/j.bbagen.2016.02.013_bb0350) 2013; 288
Chipuk (10.1016/j.bbagen.2016.02.013_bb0305) 2006; 13
Fang (10.1016/j.bbagen.2016.02.013_bb0455) 2002; 22
Galluzzi (10.1016/j.bbagen.2016.02.013_bb0085) 2009; 10
Javadov (10.1016/j.bbagen.2016.02.013_bb0280) 2013; 4
Liu (10.1016/j.bbagen.2016.02.013_bb0610) 2007; 581
Green (10.1016/j.bbagen.2016.02.013_bb0040) 2004; 305
Ohtani (10.1016/j.bbagen.2016.02.013_bb0285) 2012; 26
Zhang (10.1016/j.bbagen.2016.02.013_bb0665) 2015; 456
Dolder (10.1016/j.bbagen.2016.02.013_bb0125) 2003; 278
Tomita (10.1016/j.bbagen.2016.02.013_bb0355) 2006; 281
Montero (10.1016/j.bbagen.2016.02.013_bb0365) 2010; 1797
Symersky (10.1016/j.bbagen.2016.02.013_bb0570) 2012; 19
References_xml – volume: 27
  start-page: 4633
  year: 2008
  end-page: 4635
  ident: bb0120
  article-title: Disruption of the hexokinase–VDAC complex for tumor therapy
  publication-title: Oncogene
– volume: 591
  start-page: 5895
  year: 2013
  end-page: 5911
  ident: bb0640
  article-title: Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca
  publication-title: J. Physiol.
– volume: 149
  start-page: 1536
  year: 2012
  end-page: 1548
  ident: bb0295
  article-title: p53 opens the mitochondrial permeability transition pore to trigger necrosis
  publication-title: Cell
– volume: 174
  start-page: 915
  year: 2006
  end-page: 921
  ident: bb0530
  article-title: Structural and functional features and significance of the physical linkage between ER and mitochondria
  publication-title: J. Cell Biol.
– volume: 14
  start-page: 1275
  year: 2011
  end-page: 1288
  ident: bb0660
  article-title: Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
  publication-title: Antioxid. Redox Signal.
– volume: 384
  start-page: 201
  year: 2004
  end-page: 232
  ident: bb0035
  article-title: The protein structures that shape caspase activity, specificity, activation and inhibition
  publication-title: Biochem. J.
– volume: 278
  start-page: 17760
  year: 2003
  end-page: 17766
  ident: bb0125
  article-title: Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation
  publication-title: J. Biol. Chem.
– volume: 491
  start-page: 269
  year: 2012
  end-page: 273
  ident: bb0595
  article-title: CaMKII determines mitochondrial stress responses in heart
  publication-title: Nature
– volume: 305
  start-page: 626
  year: 2004
  end-page: 629
  ident: bb0040
  article-title: The pathophysiology of mitochondrial cell death
  publication-title: Science
– volume: 874
  start-page: 412
  year: 1999
  end-page: 426
  ident: bb0030
  article-title: Apoptosis in myocardial ischemia–reperfusion
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 21
  start-page: 749
  year: 2006
  end-page: 760
  ident: bb0115
  article-title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
  publication-title: Mol. Cell
– volume: 286
  start-page: 26334
  year: 2011
  end-page: 26343
  ident: bb0385
  article-title: Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis
  publication-title: J. Biol. Chem.
– volume: 1797
  start-page: 1113
  year: 2010
  end-page: 1118
  ident: bb0150
  article-title: Cyclophilin D in mitochondrial pathophysiology
  publication-title: Biochim. Biophys. Acta
– volume: 291
  start-page: C1159
  year: 2006
  end-page: C1171
  ident: bb0585
  article-title: Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction
  publication-title: Am. J. Physiol. Cell Physiol.
– volume: 14
  start-page: 1267
  year: 2007
  end-page: 1274
  ident: bb0520
  article-title: Mitochondrial Ca
  publication-title: Cell Death Differ.
– volume: 43
  start-page: 564
  year: 2007
  end-page: 570
  ident: bb0485
  article-title: Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection
  publication-title: J. Mol. Cell. Cardiol.
– volume: 23
  start-page: 521
  year: 2006
  end-page: 530
  ident: bb0275
  article-title: Electrophysiological characterization of the cyclophilin D-deleted mitochondrial permeability transition pore
  publication-title: Mol. Membr. Biol.
– volume: 416
  start-page: 307
  year: 1997
  end-page: 311
  ident: bb0450
  article-title: Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
  publication-title: FEBS Lett.
– volume: 102
  start-page: 12005
  year: 2005
  end-page: 12010
  ident: bb0130
  article-title: Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 55
  start-page: 1
  year: 2014
  end-page: 16
  ident: bb0360
  article-title: Metabolism and function of mitochondrial cardiolipin
  publication-title: Prog. Lipid Res.
– volume: 1817
  start-page: 381
  year: 2012
  end-page: 387
  ident: bb0325
  article-title: Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthase
  publication-title: Biochim. Biophys. Acta
– volume: 82
  start-page: 47
  year: 2002
  end-page: 95
  ident: bb0185
  article-title: Free radicals in the physiological control of cell function
  publication-title: Physiol. Rev.
– volume: 19
  start-page: 107
  year: 2012
  end-page: 120
  ident: bb0180
  article-title: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
  publication-title: Cell Death Differ.
– volume: 19
  start-page: 8469
  year: 1999
  end-page: 8478
  ident: bb0430
  article-title: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
  publication-title: Mol. Cell. Biol.
– volume: 10
  start-page: 281
  year: 1989
  end-page: 285
  ident: bb0510
  article-title: Role of Ca
  publication-title: Trends Pharmacol. Sci.
– volume: 114
  start-page: 524
  year: 2014
  end-page: 537
  ident: bb0215
  article-title: Cardiac mitochondria and reactive oxygen species generation
  publication-title: Circ. Res.
– volume: 307
  start-page: 122
  year: 1992
  end-page: 127
  ident: bb0020
  article-title: Apoptosis. Biochemical events and relevance to cancer chemotherapy
  publication-title: FEBS Lett.
– volume: 10
  start-page: 481
  year: 2009
  end-page: 494
  ident: bb0085
  article-title: Mitochondrial membrane permeabilization in neuronal injury
  publication-title: Nat. Rev. Neurosci.
– volume: 476
  start-page: 341
  year: 2011
  end-page: 345
  ident: bb0560
  article-title: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
  publication-title: Nature
– volume: 1318
  start-page: 395
  year: 1997
  end-page: 402
  ident: bb0240
  article-title: Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca
  publication-title: Biochim. Biophys. Acta
– volume: 5
  year: 2014
  ident: bb0420
  article-title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death
  publication-title: Cell Death Dis.
– volume: 181
  start-page: 1661
  year: 1995
  end-page: 1672
  ident: bb0010
  article-title: Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
  publication-title: J. Exp. Med.
– volume: 4
  start-page: 302
  year: 2014
  ident: bb0580
  article-title: The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death
  publication-title: Front. Oncol.
– volume: 19
  start-page: 159
  year: 2005
  end-page: 170
  ident: bb0465
  article-title: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin
  publication-title: Mol. Cell
– volume: 434
  start-page: 652
  year: 2005
  end-page: 658
  ident: bb0140
  article-title: Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
  publication-title: Nature
– volume: 280
  start-page: 18558
  year: 2005
  end-page: 18561
  ident: bb0145
  article-title: Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
  publication-title: J. Biol. Chem.
– volume: 33
  start-page: 9530
  year: 1994
  end-page: 9536
  ident: bb0260
  article-title: Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide
  publication-title: Biochemistry
– volume: 304
  start-page: 463
  year: 2003
  end-page: 470
  ident: bb0175
  article-title: Mitochondrial permeability transition: a common pathway to necrosis and apoptosis
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 1797
  start-page: 922
  year: 2010
  end-page: 928
  ident: bb0680
  article-title: Membrane potential-related effect of calcium on reactive oxygen species generation in isolated brain mitochondria
  publication-title: Biochim. Biophys. Acta
– volume: 3
  year: 2008
  ident: bb0705
  article-title: Mitochondrial Ca
  publication-title: PLoS One
– volume: 284
  start-page: 9692
  year: 2009
  end-page: 9699
  ident: bb0095
  article-title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect
  publication-title: J. Biol. Chem.
– volume: 303
  start-page: 1010
  year: 2004
  end-page: 1014
  ident: bb0340
  article-title: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
  publication-title: Science
– volume: 281
  start-page: 8600
  year: 2006
  end-page: 8606
  ident: bb0355
  article-title: WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
  publication-title: J. Biol. Chem.
– volume: 94
  start-page: 909
  year: 2014
  end-page: 950
  ident: bb0210
  article-title: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release
  publication-title: Physiol. Rev.
– volume: 175
  start-page: 901
  year: 2006
  end-page: 911
  ident: bb0550
  article-title: Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca
  publication-title: J. Cell Biol.
– volume: 1797
  start-page: 1217
  year: 2010
  end-page: 1224
  ident: bb0365
  article-title: Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death
  publication-title: Biochim. Biophys. Acta
– volume: 88
  start-page: 1220
  year: 2001
  end-page: 1222
  ident: bb0600
  article-title: Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis
  publication-title: Circ. Res.
– volume: 46
  start-page: 989
  year: 2009
  end-page: 997
  ident: bb0685
  article-title: Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes
  publication-title: J. Mol. Cell. Cardiol.
– volume: 288
  start-page: 7387
  year: 2013
  end-page: 7398
  ident: bb0350
  article-title: Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways
  publication-title: J. Biol. Chem.
– volume: 467
  start-page: 495
  year: 2015
  end-page: 505
  ident: bb0370
  article-title: Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
  publication-title: Biochem. J.
– volume: 87
  start-page: 99
  year: 2007
  end-page: 163
  ident: bb0055
  article-title: Mitochondrial membrane permeabilization in cell death
  publication-title: Physiol. Rev.
– volume: 99
  start-page: 382
  year: 2015
  end-page: 392
  ident: bb0165
  article-title: Cell death disguised: the mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase
  publication-title: Pharmacol. Res.
– volume: 23
  start-page: 11373
  year: 2003
  end-page: 11381
  ident: bb0440
  article-title: Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad
  publication-title: J. Neurosci.
– volume: 17
  start-page: 283
  year: 2006
  end-page: 288
  ident: bb0655
  article-title: Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus
  publication-title: Platelets
– volume: 26
  start-page: 95
  year: 2012
  end-page: 101
  ident: bb0285
  article-title: Effects of nitric oxide on mitochondrial permeability transition pore and thiol-mediated responses in cardiac myocytes
  publication-title: Nitric Oxide Biol. Chem.
– volume: 2011
  start-page: 920178
  year: 2011
  ident: bb0500
  article-title: IP(3) receptors, mitochondria, and Ca signaling: implications for aging
  publication-title: J. Aging Res.
– volume: 44
  start-page: 51
  year: 2008
  end-page: 63
  ident: bb0565
  article-title: High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling
  publication-title: Cell Calcium
– volume: 68
  start-page: 434
  year: 2008
  end-page: 443
  ident: bb0390
  article-title: Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species–c-Jun–NH2 kinase signaling
  publication-title: Cancer Res.
– volume: 8
  start-page: 863
  year: 2012
  end-page: 884
  ident: bb0630
  article-title: Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species
  publication-title: Futur. Cardiol.
– volume: 407
  start-page: 770
  year: 2000
  end-page: 776
  ident: bb0045
  article-title: The biochemistry of apoptosis
  publication-title: Nature
– volume: 495
  start-page: 12
  year: 2001
  end-page: 15
  ident: bb0235
  article-title: Mitochondrial permeability transition and oxidative stress
  publication-title: FEBS Lett.
– volume: 27
  start-page: 4221
  year: 2008
  end-page: 4232
  ident: bb0105
  article-title: Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
  publication-title: Oncogene
– volume: 50
  start-page: 234
  year: 2011
  end-page: 241
  ident: bb0615
  article-title: Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2
  publication-title: Cell Calcium
– volume: 16
  start-page: 1075
  year: 2009
  end-page: 1082
  ident: bb0070
  article-title: Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
  publication-title: Cell Death Differ.
– volume: 20
  start-page: 4305
  year: 2001
  end-page: 4316
  ident: bb0270
  article-title: The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
  publication-title: Oncogene
– volume: 268
  start-page: 22181
  year: 1993
  end-page: 22187
  ident: bb0255
  article-title: Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide
  publication-title: J. Biol. Chem.
– volume: 181
  start-page: 764
  year: 1991
  end-page: 770
  ident: bb0315
  article-title: The inactivation of mitochondrial F1 ATPase by H
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 56
  start-page: 108
  year: 2014
  end-page: 123
  ident: bb0650
  article-title: Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium/reactive oxygen and nitrogen species cross-talk signaling
  publication-title: Cell Calcium
– volume: 286
  start-page: 35071
  year: 2011
  end-page: 35078
  ident: bb0415
  article-title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
  publication-title: J. Biol. Chem.
– volume: 300
  start-page: 135
  year: 2003
  end-page: 139
  ident: bb0625
  article-title: BAX and BAK regulation of endoplasmic reticulum Ca
  publication-title: Science
– volume: 12
  start-page: 614
  year: 2005
  end-page: 626
  ident: bb0380
  article-title: tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
  publication-title: Cell Death Differ.
– volume: 3
  start-page: ra24
  year: 2010
  ident: bb0645
  article-title: Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling
  publication-title: Sci. Signal.
– volume: 19 Pt A
  start-page: 69
  year: 2014
  end-page: 77
  ident: bb0245
  article-title: VDAC phosphorylation, a lipid sensor influencing the cell fate
  publication-title: Mitochondrion
– volume: 300
  start-page: H1327
  year: 2011
  end-page: H1335
  ident: bb0290
  article-title: Characterization of potential S-nitrosylation sites in the myocardium
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 21
  start-page: 894
  year: 2009
  end-page: 899
  ident: bb0200
  article-title: Mitochondrial reactive oxygen species regulate hypoxic signaling
  publication-title: Curr. Opin. Cell Biol.
– volume: 22
  start-page: 2099
  year: 2002
  end-page: 2110
  ident: bb0455
  article-title: Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
  publication-title: Mol. Cell. Biol.
– volume: 13
  start-page: 199
  year: 2013
  end-page: 208
  ident: bb0715
  article-title: Classification of mitocans, anti-cancer drugs acting on mitochondria
  publication-title: Mitochondrion
– volume: 110
  start-page: 5887
  year: 2013
  end-page: 5892
  ident: bb0155
  article-title: Dimers of mitochondrial ATP synthase form the permeability transition pore
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 8
  start-page: 813
  year: 2007
  end-page: 824
  ident: bb0190
  article-title: ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 282
  start-page: 235
  year: 1988
  end-page: 259
  ident: bb0230
  article-title: Susceptibility of mitochondrial membranes to calcium and reactive oxygen species: implications for ischemic and toxic tissue damage
  publication-title: Prog. Clin. Biol. Res.
– volume: 270
  start-page: 29548
  year: 1995
  end-page: 29554
  ident: bb0265
  article-title: Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline
  publication-title: J. Biol. Chem.
– volume: 1504
  start-page: 220
  year: 2001
  end-page: 228
  ident: bb0575
  article-title: Stoichiometry of subunit e in rat liver mitochondrial H(+)-ATP synthase and membrane topology of its putative Ca(2
  publication-title: Biochim. Biophys. Acta
– volume: 116
  start-page: 205
  year: 2004
  end-page: 219
  ident: bb0065
  article-title: Cell death: critical control points
  publication-title: Cell
– volume: 20
  start-page: 205
  year: 2005
  end-page: 219
  ident: bb0250
  article-title: Reactive oxygen species and the mitochondrial signaling pathway of cell death
  publication-title: Histol. Histopathol.
– volume: 434
  start-page: 658
  year: 2005
  end-page: 662
  ident: bb0135
  article-title: Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
  publication-title: Nature
– volume: 14
  start-page: 355
  year: 2000
  end-page: 360
  ident: bb0220
  article-title: Mitochondrial endogenous oxidative damage has been overestimated
  publication-title: FASEB J.
– volume: 65
  start-page: 10545
  year: 2005
  end-page: 10554
  ident: bb0475
  article-title: Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
  publication-title: Cancer Res.
– volume: 27
  start-page: 6407
  year: 2008
  end-page: 6418
  ident: bb0545
  article-title: Calcium and apoptosis: ER–mitochondria Ca
  publication-title: Oncogene
– volume: 1817
  start-page: 2038
  year: 2012
  end-page: 2048
  ident: bb0320
  article-title: Reactive oxygen species affect ATP hydrolysis by targeting a highly conserved amino acid cluster in the thylakoid ATP synthase gamma subunit
  publication-title: Biochim. Biophys. Acta
– volume: 88
  start-page: 1695
  year: 2014
  end-page: 1709
  ident: bb0605
  article-title: The Ca(2
  publication-title: Arch. Toxicol.
– volume: 95
  start-page: 1111
  year: 2015
  end-page: 1155
  ident: bb0110
  article-title: The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
  publication-title: Physiol. Rev.
– volume: 16
  start-page: 607
  year: 2002
  end-page: 609
  ident: bb0075
  article-title: The permeability transition pore signals apoptosis by directing Bax translocation and multimerization
  publication-title: FASEB J.
– volume: 44
  start-page: 1529
  year: 2008
  end-page: 1535
  ident: bb0300
  article-title: ROS and p53: a versatile partnership
  publication-title: Free Radic. Biol. Med.
– volume: 13
  start-page: 994
  year: 2006
  end-page: 1002
  ident: bb0305
  article-title: Dissecting p53-dependent apoptosis
  publication-title: Cell Death Differ.
– volume: 292
  start-page: 727
  year: 2001
  end-page: 730
  ident: bb0060
  article-title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
  publication-title: Science
– volume: 2
  start-page: 754
  year: 2000
  end-page: 761
  ident: bb0375
  article-title: Cardiolipin provides specificity for targeting of tBid to mitochondria
  publication-title: Nat. Cell Biol.
– volume: 5
  year: 2013
  ident: bb0050
  article-title: Mitochondrial regulation of cell death
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 187
  start-page: 1261
  year: 1998
  end-page: 1271
  ident: bb0090
  article-title: The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins
  publication-title: J. Exp. Med.
– volume: 111
  start-page: 1237
  year: 2012
  end-page: 1247
  ident: bb0100
  article-title: Physiological roles of the permeability transition pore
  publication-title: Circ. Res.
– volume: 54
  start-page: 176
  year: 2001
  end-page: 186
  ident: bb0225
  article-title: Antioxidants in health and disease
  publication-title: J. Clin. Pathol.
– volume: 287
  start-page: C817
  year: 2004
  end-page: C833
  ident: bb0690
  article-title: Calcium, ATP, and ROS: a mitochondrial love–hate triangle
  publication-title: Am. J. Physiol. Cell Physiol.
– volume: 585
  start-page: 741
  year: 2007
  end-page: 758
  ident: bb0695
  article-title: Ca
  publication-title: J. Physiol.
– volume: 13
  start-page: 730
  year: 2006
  end-page: 737
  ident: bb0400
  article-title: Reactive oxygen species mediate crosstalk between NF-kappaB and JNK
  publication-title: Cell Death Differ.
– volume: 278
  start-page: 48872
  year: 2003
  end-page: 48879
  ident: bb0480
  article-title: Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53
  publication-title: J. Biol. Chem.
– volume: 107
  start-page: 726
  year: 2010
  end-page: 731
  ident: bb0495
  article-title: Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 17
  start-page: 175
  year: 1990
  end-page: 187
  ident: bb0515
  article-title: Role of calcium in the programmed death of rat prostatic glandular cells
  publication-title: Prostate
– volume: 292
  start-page: 73
  year: 2011
  end-page: 117
  ident: bb0540
  article-title: New insights into the role of mitochondria-associated endoplasmic reticulum membrane
  publication-title: Int. Rev. Cell Mol. Biol.
– volume: 111
  start-page: 10580
  year: 2014
  end-page: 10585
  ident: bb0160
  article-title: An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 4
  start-page: 517
  year: 2003
  end-page: 529
  ident: bb0505
  article-title: Calcium signalling: dynamics, homeostasis and remodelling
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 112
  start-page: 1779
  year: 2015
  end-page: 1784
  ident: bb0710
  article-title: p53 at the endoplasmic reticulum regulates apoptosis in a Ca
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 16
  start-page: 101
  year: 2015
  end-page: 108
  ident: bb0490
  article-title: Ischemic preconditioning-an unfulfilled promise
  publication-title: Cardiovasc. Revasc. Med.
– volume: 127
  start-page: 1823
  year: 2010
  end-page: 1832
  ident: bb0720
  article-title: Involvement of Ca
  publication-title: Int. J. Cancer
– volume: 100
  start-page: 2432
  year: 2003
  end-page: 2437
  ident: bb0435
  article-title: JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 1
  start-page: 120
  year: 2000
  end-page: 129
  ident: bb0025
  article-title: Apoptosis in neurodegenerative disorders
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 289
  start-page: 8170
  year: 2014
  end-page: 8181
  ident: bb0635
  article-title: Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species
  publication-title: J. Biol. Chem.
– volume: 113
  start-page: 1535
  year: 2004
  end-page: 1549
  ident: bb0470
  article-title: Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
  publication-title: J. Clin. Invest.
– volume: 6
  start-page: 6580
  year: 2015
  ident: bb0170
  article-title: Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity
  publication-title: Nat. Commun.
– volume: 182
  start-page: 367
  year: 1995
  end-page: 377
  ident: bb0005
  article-title: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
  publication-title: J. Exp. Med.
– volume: 97
  start-page: 11960
  year: 2000
  end-page: 11965
  ident: bb0460
  article-title: Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 74
  start-page: 4360
  year: 1977
  end-page: 4364
  ident: bb0195
  article-title: Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3′,5′-monophosphate formation
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 6
  start-page: 443
  year: 2004
  end-page: 450
  ident: bb0335
  article-title: Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex
  publication-title: Nat. Cell Biol.
– volume: 251
  start-page: 5069
  year: 1976
  end-page: 5077
  ident: bb0525
  article-title: Relationship between configuration, function, and permeability in calcium-treated mitochondria
  publication-title: J. Biol. Chem.
– volume: 13
  start-page: 787
  year: 1986
  end-page: 792
  ident: bb0590
  article-title: Identification of calmodulin-binding proteins in pure mitochondria by photoaffinity labeling
  publication-title: Biochem. Int.
– volume: 476
  start-page: 336
  year: 2011
  end-page: 340
  ident: bb0555
  article-title: A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
  publication-title: Nature
– volume: 63
  start-page: 541
  year: 2003
  end-page: 546
  ident: bb0080
  article-title: Bcl-2 and Bax modulate adenine nucleotide translocase activity
  publication-title: Cancer Res.
– volume: 24
  start-page: 255
  year: 2010
  end-page: 263
  ident: bb0445
  article-title: Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury
  publication-title: Cardiovasc. Drugs Ther.
– volume: 19
  start-page: 485
  year: 2012
  end-page: 491
  ident: bb0570
  article-title: Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation
  publication-title: Nat. Struct. Mol. Biol.
– volume: 120
  start-page: 649
  year: 2005
  end-page: 661
  ident: bb0395
  article-title: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
  publication-title: Cell
– volume: 26
  start-page: 239
  year: 1972
  end-page: 257
  ident: bb0015
  article-title: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
  publication-title: Br. J. Cancer
– volume: 456
  start-page: 926
  year: 2015
  end-page: 932
  ident: bb0665
  article-title: Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS–Ca(2
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 4
  start-page: 76
  year: 2013
  ident: bb0280
  article-title: Mitochondrial permeability transition and cell death: the role of cyclophilin d
  publication-title: Front. Physiol.
– volume: 581
  start-page: 1481
  year: 2007
  end-page: 1486
  ident: bb0610
  article-title: Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells
  publication-title: FEBS Lett.
– volume: 102
  start-page: 105
  year: 2005
  end-page: 110
  ident: bb0620
  article-title: Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 27
  start-page: 2047
  year: 2006
  end-page: 2058
  ident: bb0535
  article-title: Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress
  publication-title: Carcinogenesis
– volume: 112
  start-page: 9129
  year: 2015
  end-page: 9134
  ident: bb0700
  article-title: Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 1201
  start-page: 183
  year: 2010
  end-page: 188
  ident: bb0670
  article-title: Oxidative stress caused by mitochondrial calcium overload
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 11
  start-page: 577
  year: 2003
  end-page: 590
  ident: bb0345
  article-title: p53 has a direct apoptogenic role at the mitochondria
  publication-title: Mol. Cell
– volume: 23
  start-page: 5594
  year: 2004
  end-page: 5606
  ident: bb0425
  article-title: Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
  publication-title: Oncogene
– volume: 3
  start-page: 294
  year: 2004
  end-page: 300
  ident: bb0205
  article-title: Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness
  publication-title: Integr. Cancer Ther.
– volume: 277
  start-page: 10244
  year: 2002
  end-page: 10250
  ident: bb0410
  article-title: Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
  publication-title: J. Biol. Chem.
– volume: 80
  start-page: 293
  year: 1995
  end-page: 299
  ident: bb0330
  article-title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
  publication-title: Cell
– volume: 458
  start-page: 1127
  year: 2009
  end-page: 1130
  ident: bb0310
  article-title: Cytoplasmic functions of the tumour suppressor p53
  publication-title: Nature
– volume: 8
  start-page: 1775
  year: 2006
  end-page: 1789
  ident: bb0405
  article-title: Reactive oxygen species-induced activation of the MAP kinase signaling pathways
  publication-title: Antioxid. Redox Signal.
– volume: 20
  start-page: S413
  year: 2010
  end-page: S426
  ident: bb0675
  article-title: Calcium and mitochondrial reactive oxygen species generation: how to read the facts
  publication-title: J. Alzheimers Dis.
– volume: 1797
  start-page: 1113
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0150
  article-title: Cyclophilin D in mitochondrial pathophysiology
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2009.12.006
– volume: 22
  start-page: 2099
  year: 2002
  ident: 10.1016/j.bbagen.2016.02.013_bb0455
  article-title: Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.7.2099-2110.2002
– volume: 19
  start-page: 159
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0465
  article-title: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.06.009
– volume: 20
  start-page: S413
  issue: Suppl. 2
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0675
  article-title: Calcium and mitochondrial reactive oxygen species generation: how to read the facts
  publication-title: J. Alzheimers Dis.
  doi: 10.3233/JAD-2010-100465
– volume: 585
  start-page: 741
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0695
  article-title: Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2007.145409
– volume: 305
  start-page: 626
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0040
  article-title: The pathophysiology of mitochondrial cell death
  publication-title: Science
  doi: 10.1126/science.1099320
– volume: 458
  start-page: 1127
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0310
  article-title: Cytoplasmic functions of the tumour suppressor p53
  publication-title: Nature
  doi: 10.1038/nature07986
– volume: 2011
  start-page: 920178
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0500
  article-title: IP(3) receptors, mitochondria, and Ca signaling: implications for aging
  publication-title: J. Aging Res.
  doi: 10.4061/2011/920178
– volume: 102
  start-page: 105
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0620
  article-title: Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0408352102
– volume: 19 Pt A
  start-page: 69
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0245
  article-title: VDAC phosphorylation, a lipid sensor influencing the cell fate
  publication-title: Mitochondrion
  doi: 10.1016/j.mito.2014.07.009
– volume: 97
  start-page: 11960
  year: 2000
  ident: 10.1016/j.bbagen.2016.02.013_bb0460
  article-title: Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.220413597
– volume: 3
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0705
  article-title: Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002718
– volume: 251
  start-page: 5069
  year: 1976
  ident: 10.1016/j.bbagen.2016.02.013_bb0525
  article-title: Relationship between configuration, function, and permeability in calcium-treated mitochondria
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)33220-9
– volume: 300
  start-page: 135
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0625
  article-title: BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis
  publication-title: Science
  doi: 10.1126/science.1081208
– volume: 111
  start-page: 1237
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0100
  article-title: Physiological roles of the permeability transition pore
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.112.265942
– volume: 63
  start-page: 541
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0080
  article-title: Bcl-2 and Bax modulate adenine nucleotide translocase activity
  publication-title: Cancer Res.
– volume: 291
  start-page: C1159
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0585
  article-title: Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00207.2006
– volume: 292
  start-page: 727
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0060
  article-title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
  publication-title: Science
  doi: 10.1126/science.1059108
– volume: 581
  start-page: 1481
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0610
  article-title: Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2007.03.003
– volume: 50
  start-page: 234
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0615
  article-title: Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2011.05.011
– volume: 27
  start-page: 4221
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0105
  article-title: Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
  publication-title: Oncogene
  doi: 10.1038/onc.2008.63
– volume: 175
  start-page: 901
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0550
  article-title: Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200608073
– volume: 26
  start-page: 239
  year: 1972
  ident: 10.1016/j.bbagen.2016.02.013_bb0015
  article-title: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1972.33
– volume: 4
  start-page: 302
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0580
  article-title: The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2014.00302
– volume: 27
  start-page: 2047
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0535
  article-title: Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgl051
– volume: 20
  start-page: 205
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0250
  article-title: Reactive oxygen species and the mitochondrial signaling pathway of cell death
  publication-title: Histol. Histopathol.
– volume: 74
  start-page: 4360
  year: 1977
  ident: 10.1016/j.bbagen.2016.02.013_bb0195
  article-title: Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3′,5′-monophosphate formation
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.74.10.4360
– volume: 181
  start-page: 764
  year: 1991
  ident: 10.1016/j.bbagen.2016.02.013_bb0315
  article-title: The inactivation of mitochondrial F1 ATPase by H2O2 is mediated by iron ions not tightly bound in the protein
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/0006-291X(91)91256-C
– volume: 1
  start-page: 120
  year: 2000
  ident: 10.1016/j.bbagen.2016.02.013_bb0025
  article-title: Apoptosis in neurodegenerative disorders
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/35040009
– volume: 304
  start-page: 463
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0175
  article-title: Mitochondrial permeability transition: a common pathway to necrosis and apoptosis
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/S0006-291X(03)00618-1
– volume: 13
  start-page: 787
  year: 1986
  ident: 10.1016/j.bbagen.2016.02.013_bb0590
  article-title: Identification of calmodulin-binding proteins in pure mitochondria by photoaffinity labeling
  publication-title: Biochem. Int.
– volume: 8
  start-page: 1775
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0405
  article-title: Reactive oxygen species-induced activation of the MAP kinase signaling pathways
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2006.8.1775
– volume: 17
  start-page: 175
  year: 1990
  ident: 10.1016/j.bbagen.2016.02.013_bb0515
  article-title: Role of calcium in the programmed death of rat prostatic glandular cells
  publication-title: Prostate
  doi: 10.1002/pros.2990170302
– volume: 280
  start-page: 18558
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0145
  article-title: Properties of the permeability transition pore in mitochondria devoid of cyclophilin D
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.C500089200
– volume: 277
  start-page: 10244
  year: 2002
  ident: 10.1016/j.bbagen.2016.02.013_bb0410
  article-title: Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112355200
– volume: 13
  start-page: 994
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0305
  article-title: Dissecting p53-dependent apoptosis
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4401908
– volume: 88
  start-page: 1220
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0600
  article-title: Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis
  publication-title: Circ. Res.
  doi: 10.1161/hh1201.093159
– volume: 99
  start-page: 382
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0165
  article-title: Cell death disguised: the mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2015.04.013
– volume: 82
  start-page: 47
  year: 2002
  ident: 10.1016/j.bbagen.2016.02.013_bb0185
  article-title: Free radicals in the physiological control of cell function
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00018.2001
– volume: 27
  start-page: 4633
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0120
  article-title: Disruption of the hexokinase–VDAC complex for tumor therapy
  publication-title: Oncogene
  doi: 10.1038/onc.2008.114
– volume: 10
  start-page: 281
  year: 1989
  ident: 10.1016/j.bbagen.2016.02.013_bb0510
  article-title: Role of Ca2+ in toxic cell killing
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/0165-6147(89)90029-1
– volume: 407
  start-page: 770
  year: 2000
  ident: 10.1016/j.bbagen.2016.02.013_bb0045
  article-title: The biochemistry of apoptosis
  publication-title: Nature
  doi: 10.1038/35037710
– volume: 495
  start-page: 12
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0235
  article-title: Mitochondrial permeability transition and oxidative stress
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(01)02316-X
– volume: 181
  start-page: 1661
  year: 1995
  ident: 10.1016/j.bbagen.2016.02.013_bb0010
  article-title: Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.181.5.1661
– volume: 107
  start-page: 726
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0495
  article-title: Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0912742107
– volume: 46
  start-page: 989
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0685
  article-title: Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2008.12.022
– volume: 416
  start-page: 307
  year: 1997
  ident: 10.1016/j.bbagen.2016.02.013_bb0450
  article-title: Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(97)01235-0
– volume: 278
  start-page: 48872
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0480
  article-title: Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M305870200
– volume: 476
  start-page: 341
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0560
  article-title: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
  publication-title: Nature
  doi: 10.1038/nature10234
– volume: 33
  start-page: 9530
  year: 1994
  ident: 10.1016/j.bbagen.2016.02.013_bb0260
  article-title: Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide
  publication-title: Biochemistry
  doi: 10.1021/bi00198a019
– volume: 476
  start-page: 336
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0555
  article-title: A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
  publication-title: Nature
  doi: 10.1038/nature10230
– volume: 111
  start-page: 10580
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0160
  article-title: An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1401591111
– volume: 1817
  start-page: 381
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0325
  article-title: Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthase
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2011.11.006
– volume: 16
  start-page: 607
  year: 2002
  ident: 10.1016/j.bbagen.2016.02.013_bb0075
  article-title: The permeability transition pore signals apoptosis by directing Bax translocation and multimerization
  publication-title: FASEB J.
  doi: 10.1096/fj.01-0269fje
– volume: 288
  start-page: 7387
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0350
  article-title: Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.400754
– volume: 23
  start-page: 5594
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0425
  article-title: Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1207747
– volume: 187
  start-page: 1261
  year: 1998
  ident: 10.1016/j.bbagen.2016.02.013_bb0090
  article-title: The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.187.8.1261
– volume: 270
  start-page: 29548
  year: 1995
  ident: 10.1016/j.bbagen.2016.02.013_bb0265
  article-title: Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.49.29548
– volume: 14
  start-page: 1275
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0660
  article-title: Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3359
– volume: 14
  start-page: 355
  year: 2000
  ident: 10.1016/j.bbagen.2016.02.013_bb0220
  article-title: Mitochondrial endogenous oxidative damage has been overestimated
  publication-title: FASEB J.
  doi: 10.1096/fasebj.14.2.355
– volume: 120
  start-page: 649
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0395
  article-title: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
  publication-title: Cell
  doi: 10.1016/j.cell.2004.12.041
– volume: 24
  start-page: 255
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0445
  article-title: Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury
  publication-title: Cardiovasc. Drugs Ther.
  doi: 10.1007/s10557-010-6234-z
– volume: 289
  start-page: 8170
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0635
  article-title: Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.504159
– volume: 591
  start-page: 5895
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0640
  article-title: Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2013.260521
– volume: 268
  start-page: 22181
  year: 1993
  ident: 10.1016/j.bbagen.2016.02.013_bb0255
  article-title: Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(20)80665-6
– volume: 286
  start-page: 35071
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0415
  article-title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.276089
– volume: 1318
  start-page: 395
  year: 1997
  ident: 10.1016/j.bbagen.2016.02.013_bb0240
  article-title: Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0005-2728(96)00111-9
– volume: 4
  start-page: 517
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0505
  article-title: Calcium signalling: dynamics, homeostasis and remodelling
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1155
– volume: 281
  start-page: 8600
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0355
  article-title: WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M507611200
– volume: 491
  start-page: 269
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0595
  article-title: CaMKII determines mitochondrial stress responses in heart
  publication-title: Nature
  doi: 10.1038/nature11444
– volume: 182
  start-page: 367
  year: 1995
  ident: 10.1016/j.bbagen.2016.02.013_bb0005
  article-title: Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.182.2.367
– volume: 65
  start-page: 10545
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0475
  article-title: Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-1925
– volume: 6
  start-page: 6580
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0170
  article-title: Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7580
– volume: 8
  start-page: 863
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0630
  article-title: Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species
  publication-title: Futur. Cardiol.
  doi: 10.2217/fca.12.58
– volume: 292
  start-page: 73
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0540
  article-title: New insights into the role of mitochondria-associated endoplasmic reticulum membrane
  publication-title: Int. Rev. Cell Mol. Biol.
  doi: 10.1016/B978-0-12-386033-0.00002-5
– volume: 112
  start-page: 1779
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0710
  article-title: p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1410723112
– volume: 12
  start-page: 614
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0380
  article-title: tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4401571
– volume: 13
  start-page: 199
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0715
  article-title: Classification of mitocans, anti-cancer drugs acting on mitochondria
  publication-title: Mitochondrion
  doi: 10.1016/j.mito.2012.07.112
– volume: 23
  start-page: 521
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0275
  article-title: Electrophysiological characterization of the cyclophilin D-deleted mitochondrial permeability transition pore
  publication-title: Mol. Membr. Biol.
  doi: 10.1080/09687860600907644
– volume: 303
  start-page: 1010
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0340
  article-title: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
  publication-title: Science
  doi: 10.1126/science.1092734
– volume: 44
  start-page: 51
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0565
  article-title: High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2007.11.015
– volume: 5
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0050
  article-title: Mitochondrial regulation of cell death
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a008706
– volume: 10
  start-page: 481
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0085
  article-title: Mitochondrial membrane permeabilization in neuronal injury
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2665
– volume: 467
  start-page: 495
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0370
  article-title: Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax
  publication-title: Biochem. J.
  doi: 10.1042/BJ20141291
– volume: 54
  start-page: 176
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0225
  article-title: Antioxidants in health and disease
  publication-title: J. Clin. Pathol.
  doi: 10.1136/jcp.54.3.176
– volume: 384
  start-page: 201
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0035
  article-title: The protein structures that shape caspase activity, specificity, activation and inhibition
  publication-title: Biochem. J.
  doi: 10.1042/BJ20041142
– volume: 874
  start-page: 412
  year: 1999
  ident: 10.1016/j.bbagen.2016.02.013_bb0030
  article-title: Apoptosis in myocardial ischemia–reperfusion
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1999.tb09255.x
– volume: 149
  start-page: 1536
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0295
  article-title: p53 opens the mitochondrial permeability transition pore to trigger necrosis
  publication-title: Cell
  doi: 10.1016/j.cell.2012.05.014
– volume: 20
  start-page: 4305
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0270
  article-title: The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1204575
– volume: 286
  start-page: 26334
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0385
  article-title: Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.188516
– volume: 300
  start-page: H1327
  year: 2011
  ident: 10.1016/j.bbagen.2016.02.013_bb0290
  article-title: Characterization of potential S-nitrosylation sites in the myocardium
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00997.2010
– volume: 88
  start-page: 1695
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0605
  article-title: The Ca(2+)-calmodulin-Ca(2+)/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-014-1219-5
– volume: 21
  start-page: 894
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0200
  article-title: Mitochondrial reactive oxygen species regulate hypoxic signaling
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2009.08.005
– volume: 19
  start-page: 8469
  year: 1999
  ident: 10.1016/j.bbagen.2016.02.013_bb0430
  article-title: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.12.8469
– volume: 26
  start-page: 95
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0285
  article-title: Effects of nitric oxide on mitochondrial permeability transition pore and thiol-mediated responses in cardiac myocytes
  publication-title: Nitric Oxide Biol. Chem.
  doi: 10.1016/j.niox.2011.12.007
– volume: 1797
  start-page: 1217
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0365
  article-title: Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2010.02.010
– volume: 116
  start-page: 205
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0065
  article-title: Cell death: critical control points
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00046-7
– volume: 434
  start-page: 652
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0140
  article-title: Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
  publication-title: Nature
  doi: 10.1038/nature03317
– volume: 2
  start-page: 754
  year: 2000
  ident: 10.1016/j.bbagen.2016.02.013_bb0375
  article-title: Cardiolipin provides specificity for targeting of tBid to mitochondria
  publication-title: Nat. Cell Biol.
  doi: 10.1038/35036395
– volume: 6
  start-page: 443
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0335
  article-title: Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1123
– volume: 127
  start-page: 1823
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0720
  article-title: Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25204
– volume: 100
  start-page: 2432
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0435
  article-title: JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0438011100
– volume: 55
  start-page: 1
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0360
  article-title: Metabolism and function of mitochondrial cardiolipin
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2014.04.001
– volume: 112
  start-page: 9129
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0700
  article-title: Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1504705112
– volume: 16
  start-page: 101
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0490
  article-title: Ischemic preconditioning-an unfulfilled promise
  publication-title: Cardiovasc. Revasc. Med.
  doi: 10.1016/j.carrev.2014.12.010
– volume: 113
  start-page: 1535
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0470
  article-title: Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI19906
– volume: 1504
  start-page: 220
  year: 2001
  ident: 10.1016/j.bbagen.2016.02.013_bb0575
  article-title: Stoichiometry of subunit e in rat liver mitochondrial H(+)-ATP synthase and membrane topology of its putative Ca(2+)-dependent regulatory region
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0005-2728(00)00248-6
– volume: 278
  start-page: 17760
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0125
  article-title: Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M208705200
– volume: 110
  start-page: 5887
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0155
  article-title: Dimers of mitochondrial ATP synthase form the permeability transition pore
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1217823110
– volume: 1797
  start-page: 922
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0680
  article-title: Membrane potential-related effect of calcium on reactive oxygen species generation in isolated brain mitochondria
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2010.03.010
– volume: 287
  start-page: C817
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0690
  article-title: Calcium, ATP, and ROS: a mitochondrial love–hate triangle
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00139.2004
– volume: 16
  start-page: 1075
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0070
  article-title: Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2009.61
– volume: 282
  start-page: 235
  year: 1988
  ident: 10.1016/j.bbagen.2016.02.013_bb0230
  article-title: Susceptibility of mitochondrial membranes to calcium and reactive oxygen species: implications for ischemic and toxic tissue damage
  publication-title: Prog. Clin. Biol. Res.
– volume: 5
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0420
  article-title: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2013.522
– volume: 4
  start-page: 76
  year: 2013
  ident: 10.1016/j.bbagen.2016.02.013_bb0280
  article-title: Mitochondrial permeability transition and cell death: the role of cyclophilin d
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2013.00076
– volume: 94
  start-page: 909
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0210
  article-title: Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00026.2013
– volume: 1201
  start-page: 183
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0670
  article-title: Oxidative stress caused by mitochondrial calcium overload
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2010.05634.x
– volume: 114
  start-page: 524
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0215
  article-title: Cardiac mitochondria and reactive oxygen species generation
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.114.300559
– volume: 3
  start-page: ra24
  year: 2010
  ident: 10.1016/j.bbagen.2016.02.013_bb0645
  article-title: Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000672
– volume: 56
  start-page: 108
  year: 2014
  ident: 10.1016/j.bbagen.2016.02.013_bb0650
  article-title: Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium/reactive oxygen and nitrogen species cross-talk signaling
  publication-title: Cell Calcium
  doi: 10.1016/j.ceca.2014.06.002
– volume: 17
  start-page: 283
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0655
  article-title: Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus
  publication-title: Platelets
  doi: 10.1080/09537100600745187
– volume: 23
  start-page: 11373
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0440
  article-title: Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.23-36-11373.2003
– volume: 43
  start-page: 564
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0485
  article-title: Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2007.08.010
– volume: 21
  start-page: 749
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0115
  article-title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.02.009
– volume: 284
  start-page: 9692
  year: 2009
  ident: 10.1016/j.bbagen.2016.02.013_bb0095
  article-title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M808750200
– volume: 102
  start-page: 12005
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0130
  article-title: Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0505294102
– volume: 3
  start-page: 294
  year: 2004
  ident: 10.1016/j.bbagen.2016.02.013_bb0205
  article-title: Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness
  publication-title: Integr. Cancer Ther.
  doi: 10.1177/1534735404270335
– volume: 434
  start-page: 658
  year: 2005
  ident: 10.1016/j.bbagen.2016.02.013_bb0135
  article-title: Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
  publication-title: Nature
  doi: 10.1038/nature03434
– volume: 80
  start-page: 293
  year: 1995
  ident: 10.1016/j.bbagen.2016.02.013_bb0330
  article-title: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90412-3
– volume: 456
  start-page: 926
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0665
  article-title: Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS–Ca(2+)–JNK mitochondrial pathways
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2014.12.036
– volume: 1817
  start-page: 2038
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0320
  article-title: Reactive oxygen species affect ATP hydrolysis by targeting a highly conserved amino acid cluster in the thylakoid ATP synthase gamma subunit
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2012.06.007
– volume: 307
  start-page: 122
  year: 1992
  ident: 10.1016/j.bbagen.2016.02.013_bb0020
  article-title: Apoptosis. Biochemical events and relevance to cancer chemotherapy
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(92)80914-3
– volume: 14
  start-page: 1267
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0520
  article-title: Mitochondrial Ca2+ as a key regulator of cell life and death
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4402147
– volume: 44
  start-page: 1529
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0300
  article-title: ROS and p53: a versatile partnership
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2008.01.011
– volume: 95
  start-page: 1111
  year: 2015
  ident: 10.1016/j.bbagen.2016.02.013_bb0110
  article-title: The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00001.2015
– volume: 174
  start-page: 915
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0530
  article-title: Structural and functional features and significance of the physical linkage between ER and mitochondria
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200604016
– volume: 27
  start-page: 6407
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0545
  article-title: Calcium and apoptosis: ER–mitochondria Ca2+ transfer in the control of apoptosis
  publication-title: Oncogene
  doi: 10.1038/onc.2008.308
– volume: 11
  start-page: 577
  year: 2003
  ident: 10.1016/j.bbagen.2016.02.013_bb0345
  article-title: p53 has a direct apoptogenic role at the mitochondria
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(03)00050-9
– volume: 19
  start-page: 485
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0570
  article-title: Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2284
– volume: 19
  start-page: 107
  year: 2012
  ident: 10.1016/j.bbagen.2016.02.013_bb0180
  article-title: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2011.96
– volume: 13
  start-page: 730
  year: 2006
  ident: 10.1016/j.bbagen.2016.02.013_bb0400
  article-title: Reactive oxygen species mediate crosstalk between NF-kappaB and JNK
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4401830
– volume: 87
  start-page: 99
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0055
  article-title: Mitochondrial membrane permeabilization in cell death
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00013.2006
– volume: 8
  start-page: 813
  year: 2007
  ident: 10.1016/j.bbagen.2016.02.013_bb0190
  article-title: ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2256
– volume: 68
  start-page: 434
  year: 2008
  ident: 10.1016/j.bbagen.2016.02.013_bb0390
  article-title: Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species–c-Jun–NH2 kinase signaling
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-2931
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Snippet Mitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in numerous...
BACKGROUNDMitochondrial membrane permeabilisation (MMP) is classically considered as a point of no return in several forms of cell death and is involved in...
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SubjectTerms Animals
Apoptosis
Calcium
Calcium - metabolism
cell death
cytotoxicity
Humans
Intrinsic pathway
ischemia
Mitochondria
mitochondrial membrane
Mitochondrial Membranes - metabolism
Mitochondrial permeabilisation
neoplasms
neurodegenerative diseases
Permeability
Reactive oxygen species
Reactive Oxygen Species - metabolism
Title How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?
URI https://dx.doi.org/10.1016/j.bbagen.2016.02.013
https://www.ncbi.nlm.nih.gov/pubmed/26922832
https://www.proquest.com/docview/1782216361
https://www.proquest.com/docview/1825434760
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