Helminth-induced CD9+ B-cell subset alleviates obesity-associated inflammation via IL-10 production

• Published in: International journal for parasitology Vol. 52; no. 2-3; pp. 111 - 123
• Main Authors: Li, Maining, Wang, Huiquan, Ni, Yangyue, Li, Chen, Xu, Xuejun, Chang, Hao, Xu, Zhipeng, Hou, Min, Ji, Minjun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2022
• Subjects: Animals; Antigens, CD19 - metabolism; B-lymphocytes; B-Lymphocytes, Regulatory; CD9; helminthiasis; Helminths; Helminths - metabolism; high fat diet; homeostasis; Immunometabolism; Inflammation; insulin resistance; interleukin-10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Mice; Mice, Inbred C57BL; obesity; Obesity - complications; Obesity - metabolism; parasitology; Regulatory B cell; Schistosoma japonicum; sequence analysis; spleen; Immunometabolism; CD9; Regulatory B cell; Helminths

[Display omitted] •Schistosome infection could expand regulatory B cells (Bregs) in mice.•CD19±CD9± B cells produced more IL-10 than conventional B10 cells.•Adoptive transfer of CD9± B cells from infected mice had the capacity to markedly alleviate obesity-related inflammation.•CD9± B cells induced...