Circular RNA translation: novel protein isoforms and clinical significance

• Published in: Trends in molecular medicine Vol. 28; no. 5; pp. 405 - 420
• Main Authors: Wen, Shuo-yang, Qadir, Javeria, Yang, Burton B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2022
• Subjects: circRNA translation; circular RNA; disease modulation; Gene Expression Regulation; Humans; Internal Ribosome Entry Sites - genetics; Protein Biosynthesis; Protein Isoforms - genetics; Protein Isoforms - metabolism; RNA - genetics; RNA - metabolism; RNA, Circular - genetics; rolling translation; targeting translation; therapy; translational inhibition; rolling translation; targeting translation; circular RNA; therapy; translational inhibition; circRNA translation; disease modulation

In recent years, significant attention has focused on circular RNA (circRNA) translation to determine its clinical significance. Cap-independent translation of circRNAs driven by an internal ribosome entry site (IRES) or an N6-methyladenosine (m6A)-containing short sequence is different from the can...