Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages

• Published in: Biochimica et biophysica acta Vol. 1840; no. 10; pp. 3170 - 3180
• Main Authors: Fujita, Ryo, Kawano, Fumimori, Ohira, Takashi, Nakai, Naoya, Shibaguchi, Tsubasa, Nishimoto, Norihiro, Ohira, Yoshinobu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2014
• Subjects: Animals; Anti-mouse IL-6 receptor (IL-6R) antibody; antibodies; Antibodies, Monoclonal - pharmacology; arginase; Arginase - genetics; Arginase - metabolism; Fibrosis; Gene Expression Regulation - drug effects; genes; half life; interleukin-10; Interleukin-10 - genetics; Interleukin-10 - metabolism; interleukin-6; macrophages; Macrophages - metabolism; Macrophages - pathology; Mice; Mice, Knockout; muscle development; Muscle injury; Muscle Proteins - biosynthesis; Muscle Proteins - genetics; Muscle regeneration; Muscle, Skeletal - injuries; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; muscles; phosphorylation; Rats; Receptors, Interleukin-6 - antagonists & inhibitors; Receptors, Interleukin-6 - genetics; Receptors, Interleukin-6 - metabolism; Regeneration - drug effects; Regeneration - genetics; signal transduction; skeletal muscle; transactivators; Muscle injury; MR16-1; LMD; Anti-mouse IL-6 receptor (IL-6R) antibody; CTX; STAT3; Fibrosis; Muscle regeneration

Although rat anti-mouse IL-6 receptor (IL-6R) antibody (MR16-1) has been reported to effectively ameliorate various tissue damages, its effect on skeletal muscle regeneration has not been determined. Moreover, the localization, persistence and duration of action of this reagent in damaged tissues af...