Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis

• Published in: The Journal of immunology (1950) Vol. 185; no. 9; pp. 5476 - 5485
• Main Authors: Huang, Max Tze-Han, Mortensen, Brittany L, Taxman, Debra J, Craven, Robin R, Taft-Benz, Sharon, Kijek, Todd M, Fuller, James R, Davis, Beckley K, Allen, Irving Coy, Brickey, Willie June, Gris, Denis, Wen, Haitao, Kawula, Thomas H, Ting, Jenny Pan-Yun
• Format: Journal Article
• Language: English
• Published: United States 01.11.2010
• Subjects: Animals; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Bacterial Proteins - metabolism; Blotting, Western; Cytokines - biosynthesis; Enzyme-Linked Immunosorbent Assay; Female; Francisella tularensis - genetics; Francisella tularensis - immunology; Francisella tularensis - pathogenicity; Genes, Bacterial - genetics; Genes, Bacterial - immunology; Humans; Immune Evasion - genetics; Immune Evasion - immunology; Inflammation - genetics; Inflammation - immunology; Macrophages - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - immunology; Signal Transduction - genetics; Signal Transduction - immunology; Tularemia - genetics; Tularemia - immunology

Francisella tularensis is a facultative intracellular pathogen and potential biothreat agent. Evasion of the immune response contributes to the extraordinary virulence of this organism although the mechanism is unclear. Whereas wild-type strains induced low levels of cytokines, an F. tularensis ripA...