Discovery of potential therapeutic targets for non-small cell lung cancer using high-throughput metabolomics analysis based on liquid chromatography coupled with tandem mass spectrometry

• Published in: RSC advances Vol. 9; no. 19; pp. 195 - 1913
• Main Authors: Xu, Hong-dan, Luo, Wen, Lin, Yuanlong, Zhang, Jiawen, Zhang, Lijuan, Zhang, Wei, Huang, Shu-ming
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 08.04.2019; The Royal Society of Chemistry
• Subjects: Biomarkers; Biosynthesis; Cancer; Chemistry; Chromatography; data collection; Enzymes; fatty acids; Glycine; health promotion; Liquid chromatography; Lung cancer; lung neoplasms; Mass spectrometry; Metabolism; Metabolites; metabolome; metabolomics; morbidity; patients; phosphoglycerate dehydrogenase; phosphoserine phosphatase; Proteomics; quality of life; Quantitative analysis; Scientific imaging; serine; Spectroscopy; sphingolipids; tandem mass spectrometry; therapeutics; threonine; Tyrosinase; Tyrosine; Variation

Lung cancer is a severe health problem and threatens a patient's quality of life. The metabolites present in biological systems are expected to be key mediators and the changes in these metabolites play an important role in promoting health. Metabolomics can unravel the global metabolic changes...