Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape

• Published in: Journal of neuroimmunology Vol. 381; p. 578141
• Main Authors: Hawes, I.A., Alvarenga, B.D., Browne, W., Wapniarski, A., Dandekar, R., Bartley, C.M., Sowa, G.M., DeRisi, J.L., Cinque, P., Dravid, A.N., Pleasure, S.J., Gisslen, M., Price, R.W., Wilson, M.R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2023
• Subjects: Asymptomatic escape; Autoantigens; Autoimmunity; Case-Control Studies; Central Nervous System; Coinfection; Epstein-Barr Virus Infections; escape; Herpesvirus 4, Human; HIV; HIV Infections - cerebrospinal fluid; Humans; Metagenomic next-generation sequencing; Neuroinflammation; Neurosciences; Neurosymptomatic; Neurosymptomatic escape; Neurovetenskaper; Programmable phage display; Neuroinflammation; Metagenomic next-generation sequencing; HIV; Asymptomatic escape; Programmable phage display; Neurosymptomatic escape
• ISSN: 0165-5728; 1872-8421; 1872-8421
• DOI: 10.1016/j.jneuroim.2023.578141

Antiretroviral therapy (ART) suppresses plasma and cerebrospinal fluid (CSF) HIV replication. Neurosymptomatic (NS) CSF escape is a rare exception in which CNS HIV replication occurs in the setting of neurologic impairment. The origins of NS escape are not fully understood. We performed a case-contr...