Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs - Tomicic, Maja T.; Aasland, Dorthe; Nikolova, Teodora; Kaina, Bernd; Christmann, Markus (Biochimica et biophysica acta, 2013)
Keywords: Anticancer drug; antineoplastic agents; Antineoplastic Agents - pharmacology; AP-1; binding sites; Binding Sites - drug effects; Binding Sites - genetics; cell death; Cell Death - drug effects; Cell Death - genetics; Cell Line; Cell Line, Tumor; crosslinking; DNA damage; DNA Damage - drug effects; DNA Damage - genetics; DNA repair; DNA Repair - drug effects; DNA Replication - drug effects; DNA Replication - genetics; DNA topoisomerase; Down-Regulation - drug effects; Down-Regulation - genetics; Drug Resistance, Neoplasm; Exodeoxyribonucleases - genetics; Exodeoxyribonucleases - metabolism; fibroblasts; gene expression; gene expression regulation; Gene Expression Regulation, Neoplastic - drug effects; Genes, jun - genetics; genotoxicity; Glioma; Glioma - drug therapy; Glioma - genetics; Glioma - metabolism; Humans; ionizing radiation; Melanoma; Melanoma - drug therapy; Melanoma - genetics; Melanoma - metabolism; messenger RNA; mutation; Mutation - drug effects; neoplasm cells; Phosphoproteins - genetics; Phosphoproteins - metabolism; Promoter Regions, Genetic - drug effects; Proto-Oncogene Proteins c-fos - genetics; Proto-Oncogene Proteins c-fos - metabolism; RNA, Messenger - genetics; small interfering RNA; therapeutics; transcription (genetics); Transcription Factor AP-1 - genetics; Transcription Factor AP-1 - metabolism; Transcriptional Activation - drug effects; Transcriptional Activation - genetics; Transcriptional regulation; TREX1; ultraviolet radiation; Up-Regulation - drug effects; Anticancer drug; Glioma; Transcriptional regulation; AP-1; TREX1; Melanoma