Lectinology 4.0: Altering modular (ga)lectin display for functional analysis and biomedical applications

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 5; pp. 935 - 940
• Main Authors: Ludwig, Anna-Kristin, Kaltner, Herbert, Kopitz, Jürgen, Gabius, Hans-Joachim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019
• Subjects: Cell adhesion; galectins; Glycoconjugate; humans; Lectin; Mutagenesis; polysaccharides; structure-activity relationships; Sugar code; Lectin; Sugar code; Glycoconjugate; Mutagenesis; Cell adhesion

Recognition of glycans by lectins is emerging as (patho)physiologically broadly used mode of cellular information transfer. Whereas the direct ligand-receptor contact is often already thoroughly characterized, the functional relevance of aspects of architecture such as modular design and valence of...