Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives - Wu, Yue; Zan, Li-Peng; Wang, Xiao-Dong; Lu, Yu-Jing; Ou, Tian-Miao; Lin, Jing; Huang, Zhi-Shu; Gu, Lian-Quan (Biochimica et biophysica acta, 2014)
Keywords: Alkaloids - chemistry; Alkaloids - pharmacokinetics; Alkaloids - pharmacology; Angiogenesis; Animals; Anti-tumor; antineoplastic activity; carcinogenesis; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - genetics; cell proliferation; Cell Proliferation - drug effects; Chick Embryo; chickens; chicks; chorioallantoic membrane; Circular Dichroism; circular dichroism spectroscopy; CpG Islands; cytokines; DNA; embryogenesis; enzyme-linked immunosorbent assay; G-quadruplex; genes; Humans; Indoles - chemistry; Indoles - pharmacokinetics; Indoles - pharmacology; Ligands; luciferase; neoplasm cells; neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; promoter regions; Promoter Regions, Genetic; Quindoline derivative; Quinolines - chemistry; Quinolines - pharmacokinetics; Quinolines - pharmacology; reverse transcriptase polymerase chain reaction; RNA; survival rate; transcription (genetics); Transcription, Genetic - drug effects; Transcription, Genetic - genetics; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics; vascular endothelial growth factors; VEGF; Quindoline derivative; Angiogenesis; Anti-tumor; VEGF; G-quadruplex