Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4)

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 11; pp. 2710 - 2716
• Main Authors: Gryzik, Magdalena, Srivastava, Ayush, Longhi, Giovanna, Bertuzzi, Michela, Gianoncelli, Alessandra, Carmona, Fernando, Poli, Maura, Arosio, Paolo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: Autophagy - genetics; divalent metals; electrophoresis; enzyme-linked immunosorbent assay; Escherichia coli; Escherichia coli - genetics; Ferritin; Ferritinophagy; Ferritins - chemistry; Ferritins - deficiency; Ferritins - genetics; Ferritins - metabolism; Gene Expression Regulation - genetics; Homeostasis; Humans; iron; Iron - chemistry; Iron metabolism; metal ions; mutants; NCOA4; Nuclear Receptor Coactivators - chemistry; Nuclear Receptor Coactivators - genetics; Nuclear Receptor Coactivators - metabolism; Phagosomes - genetics; Phagosomes - metabolism; Protein Binding; Protein Domains; Ferritinophagy; Iron metabolism; FtMt; NCOA4; Ferritin; FTH; FTL

Ferritinophagy is the process of autophagic degradation of ferritin that participates in the regulation of cellular iron homeostasis. This process was shown to be mediated by the selective cargo-receptor Nuclear Receptor Coactivator-4 (NCOA4) that binds ferritin and targets it to emerging autophagos...