The role of mitochondrial electron transport in tumorigenesis and metastasis

• Published in: Biochimica et biophysica acta Vol. 1840; no. 4; pp. 1454 - 1463
• Main Authors: Tan, An S., Baty, James W., Berridge, Michael V.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2014
• Subjects: Animals; blood; carcinogenesis; Carcinogenesis - genetics; electron transfer; Electron Transport - genetics; energy; energy metabolism; epigenetics; glycolysis; Humans; lymphatic system; Metabolic flexibility; Metastasis; mitochondria; Mitochondria - genetics; Mitochondrial electron transport; mitochondrial genome; Mitochondrial mutation; Mitochondrial respiration; Mutation; neoplasm cells; Neoplasm Metastasis - genetics; neoplasms; phenotype; stromal cells; Tumor Microenvironment; Tumorigenesis; Mitochondrial respiration; Tumorigenesis; Metastasis; Metabolic flexibility; Mitochondrial electron transport; Mitochondrial mutation

Tumor formation and spread via the circulatory and lymphatic drainage systems is associated with metabolic reprogramming that often includes increased glycolytic metabolism relative to mitochondrial energy production. However, cells within a tumor are not identical due to genetic change, clonal evol...