Prostate carcinoma cell-derived exosomal MicroRNA-26a modulates the metastasis and tumor growth of prostate carcinoma

• Published in: Biomedicine & pharmacotherapy Vol. 117; p. 109109
• Main Authors: Wang, Xiaobin, Wang, Xi, Zhu, Zhiyi, Li, Wensheng, Yu, Guoqiang, Jia, Zhaohui, Wang, Xiangwei
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2019
• Subjects: Animals; Castration-resistant prostate carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition - genetics; Exosomes; Exosomes - metabolism; Exosomes - ultrastructure; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; microRNA-26a; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasm Invasiveness; Neoplasm Metastasis; Prostate carcinoma; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Prostate carcinoma; microRNA-26a; Exosomes; Castration-resistant prostate carcinoma

Prostate carcinoma may develop into metastatic castration-resistant prostate carcinoma (mCRPC) after endocrine therapy. Exosomal microRNAs play an important role in the regulation of tumor microenvironment. Our study aimed to investigate the effect of exosomal miR-26a on tumor phenotype of prostate...