Metabolic reprogramming due to hypoxia in pancreatic cancer: Implications for tumor formation, immunity, and more

• Published in: Biomedicine & pharmacotherapy Vol. 141; p. 111798
• Main Authors: Hao, Xiaodong, Ren, Yidan, Feng, Maoxiao, Wang, Qin, Wang, Yunshan
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2021
• Subjects: Animals; Cellular Reprogramming - physiology; Humans; Hypoxia; Immunosuppressive microenvironment; Metabolic reprogramming; Pancreatic cancer (PC); Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - metabolism; Tumor Burden - physiology; Tumor Hypoxia - physiology; Tumor Microenvironment - physiology; Hypoxia; Pancreatic cancer (PC); Metabolic reprogramming; Immunosuppressive microenvironment

Hypoxia is a common phenomenon in most malignant tumors, especially in pancreatic cancer (PC). Hypoxia is the result of unlimited tumor growth and plays an active role in promoting tumor survival, progression, and invasion. As the part of the hypoxia microenvironment in PC is gradually clarified, hy...