Physicochemical interaction mechanism between nanoparticles and tetrasaccharides (stachyose) during freeze-drying

• Published in: Drug development and industrial pharmacy Vol. 43; no. 12; p. 2026
• Main Authors: Kamiya, Seitaro, Nakashima, Kenichiro
• Format: Journal Article
• Language: English
• Published: England 02.12.2017
• Subjects: Carbohydrates - chemistry; Crystallization; Freeze Drying - methods; Nanoparticles - chemistry; Oligosaccharides - chemistry; Powders - chemistry; Suspensions - chemistry; X-Ray Diffraction; Nanoparticles; tetrasaccharides; interactive mechanism; freeze-drying; stachyose; endothermic peak; powder X-ray diffraction

Nanoparticle suspensions are thermodynamically unstable and subject to aggregation. Freeze-drying on addition of saccharides is a useful method for preventing aggregation. In the present study, tetrasaccharides (stachyose) was employed as an additive. In addition, we hypothesize the interactive mech...