MHC Class II-Regulated Central Nervous System Autoaggression and T Cell Responses in Peripheral Lymphoid Tissues Are Dissociated in Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis

• Published in: The Journal of immunology (1950) Vol. 166; no. 12; pp. 7588 - 7599
• Main Authors: Weissert, Robert, de Graaf, Katrien L, Storch, Maria K, Barth, Silvia, Linington, Christopher, Lassmann, Hans, Olsson, Tomas
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.06.2001
• Subjects: Alleles; Amino Acid Sequence; Animals; Animals, Congenic; Autoantigens - analysis; Autoantigens - immunology; B-Lymphocytes - immunology; Cells, Cultured; Central Nervous System - immunology; Central Nervous System - pathology; Chromatography, Affinity; Encephalomyelitis, Autoimmune, Experimental - etiology; Encephalomyelitis, Autoimmune, Experimental - genetics; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Epitopes, B-Lymphocyte - analysis; Epitopes, B-Lymphocyte - immunology; Epitopes, T-Lymphocyte - analysis; Epitopes, T-Lymphocyte - immunology; Female; Genes, MHC Class I; Genes, MHC Class II; Histocompatibility Antigens Class II - genetics; Histocompatibility Antigens Class II - isolation & purification; Histocompatibility Antigens Class II - metabolism; Histocompatibility Antigens Class II - physiology; Immune Tolerance; Lymphoid Tissue - immunology; Lymphoid Tissue - pathology; Medicin och hälsovetenskap; Molecular Sequence Data; Myelin Proteins; Myelin-Associated Glycoprotein - administration & dosage; Myelin-Associated Glycoprotein - immunology; Myelin-Associated Glycoprotein - metabolism; Myelin-Oligodendrocyte Glycoprotein; Nasal Mucosa - immunology; Peptide Fragments - administration & dosage; Peptide Fragments - immunology; Peptide Fragments - metabolism; Peptide Mapping; Protein Binding - genetics; Protein Binding - immunology; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Species Specificity; T-Lymphocytes - immunology; Vaccination

We dissected the requirements for disease induction of myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in MHC (RT1 in rat) congenic rats with overlapping MOG peptides. Immunodominance with regard to peptide-specific T cell responses was purely MHC class II...