TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM2.5 and Ultrafine Particles and Historically Showing Alzheimer and Parkinson’s Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations

• Published in: Toxics (Basel) Vol. 10; no. 10; p. 559
• Main Authors: Calderón-Garcidueñas, Lilian, Stommel, Elijah W., Lachmann, Ingolf, Waniek, Katharina, Chao, Chih-Kai, González-Maciel, Angélica, García-Rojas, Edgar, Torres-Jardón, Ricardo, Delgado-Chávez, Ricardo, Mukherjee, Partha S.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.09.2022; MDPI
• Subjects: Air pollution; ALS; Alzheimer's disease; Alzheimer’s; Amyotrophic lateral sclerosis; Autopsies; Autopsy; Aβ1–42; Brain research; Brain-derived neurotrophic factor; Cerebrospinal fluid; Children; Dementia; DNA-binding protein; Emissions; Exposure; Medulla oblongata; Megacities; Motor nuclei; Movement disorders; Neurological diseases; Nitrogen dioxide; Olfactory bulb; Oxidative stress; Parkinson's disease; Particulate emissions; Particulate matter; Pathology; Pollution control; Pollution monitoring; Pons; Proteins; Public health; Reticular formation; Trends; Ultrafines; Young adults; α synuclein; Mexico; North America; Mexico City Mexico

Environmental exposures to fine particulate matter (PM2.5) and ultrafine particle matter (UFPM) are associated with overlapping Alzheimer’s, Parkinson’s and TAR DNA-binding protein 43 (TDP-43) hallmark protein pathologies in young Metropolitan Mexico City (MMC) urbanites. We measured CSF concentrati...